甲磺酸加贝酯

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • MSDS
  • 海关数据

甲磺酸加贝酯 基本信息

中文名称:
甲磺酸加贝酯 
中文别名:
甲磺酸加贝酯 
英文名称:
Benzoic acid,4-[[6-[(aminoiminomethyl)amino]-1-oxohexyl]oxy]-, ethyl ester
英文别名:
GABEXATE;
GabexateMesylateBase;
[N'-[5-(4-ethoxycarbonylphenoxy)carbonylpentyl]carbamimidoyl]azanium methanesulfonate;
4-[(6-Guanidinohexanoyl)oxy]benzoic acid ethyl ester;
4-[[6-[[Amino(imino)methyl]amino]-1-oxohexyl]oxy]benzoic acid ethyl ester 
CAS No.:
39492-01-8
分 子 式:
C16H23N3O4
分 子 量:
321.37
精确分子量:
417.15700
PSA:
177.25000
分子结构式:
SDS:
查看

甲磺酸加贝酯 制备方法及用途

制备方法

1.非肽类蛋白水解酶抑制剂。2.用于急性胰腺炎、慢性再发性胰腺炎的急性发作、术后并发的急性胰腺炎、频发性血管血栓滞固症等的治疗。3.加贝酯是一种非肽类蛋白的抑制剂,可抑制胰蛋白酶、激汰释放酶、纤维蛋白溶酶、凝血酶等蛋白酶的活性,从而制止这些酶所造成的病理生理变化。4.在动物实验性急性胰腺炎,可抑制活化的胰蛋白酶、减轻胰腺损伤,同时血清淀粉酶、脂肪酶活性和尿素氮升高情况也明显改善。

用途简介

甲磺酸加贝酯 物化性质

密度:
1.2g/cm3
沸点:
508.6ºC at 760mmHg
闪点:
261.4ºC

甲磺酸加贝酯 安全信息

海关代码:
2925290090

甲磺酸加贝酯 MSDS

  Material Safety Data Sheet

Section 1. Identification of the substance
    Product Name:      Gabexate mesylate    
    Synonyms:

Section 2. Hazards identification
    Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        Gabexate mesylate    
    CAS number:        39492-01-8    

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing    
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate    
    flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.    
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.    

Section 5. Fire fighting measures
    In the event of a fire involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator    
    Hand precaution:        Wear suitable gloves/gauntlets    
    Skin protection:        Wear suitable protective clothing    
    Eye protection:        Wear suitable eye protection    
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly qualified    
    in the handling and use of potentially hazardous chemicals, who should take into account the fire,
    health and chemical hazard data given on this sheet.
    Store in closed vessels.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not specified    
    Boiling point:        No data    
    No data
    Melting point:
    Flash point:        No data    
    Density:        No data    
    Molecular formula:        C16H23N3O4.CH4O3S    
    Molecular weight:        417.5    

Section 10. Stability and reactivity
    Conditions to avoid: Heat, flames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section 11. Toxicological information
    No data.

Section 12. Ecological information
    No data.

Section 13. Disposal consideration
    Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
    disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
    Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.


SECTION 16 - ADDITIONAL INFORMATION
N/A

甲磺酸加贝酯 海关数据

中国海关编码:2925290090

概述:
2925290090 其他亚胺及其衍生物,以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%
申报要素:
品名, 成分含量, 用途
摘要/Summary:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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产品介绍:
产品名称:甲磺酸加贝酯 Cas号:39492-01-8 纯度:99% 包装信息:100kg 价格:洽谈
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