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(R)-盐酸布比卡因
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 海关数据
- 下游产品
(R)-盐酸布比卡因 基本信息
- 中文名称：
- (R)-盐酸布比卡因
- 中文别名：
- (R)-(+)-丁哌卡因盐酸盐;
(R)-盐酸布比卡因
- 英文名称：
- 2-Piperidinecarboxamide,1-butyl-N-(2,6-dimethylphenyl)-, (2R)-
- 英文别名：
- dextrobupivacaine;
(R)-(+)-BUPIVACAINE;
(R)-Bupivacaine;
(R)-(+)-Bupivacaine;
(+)-Bupivacaine;
(+)-(R)-Bupivacaine
- CAS No.：
- 27262-45-9
- 分 子 式：
- C18H28N2O
- 分 子 量：
- 288.48
- 精确分子量：
- 288.22000
- PSA：
- 32.34000
- InChI：
- The Key: LEBVLXFERQHONN-UHFFFAOYSA-N
- 安全术语：
- Poison by subcutaneous, intratracheal and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. See other bupicaine or bupivacaine entries.
- 分子结构式：
-
- SDS：
- 查看
(R)-盐酸布比卡因 物化性质
- 密度：
- 1.032 g/cm3
- 沸点：
- 423.4ºC
- 闪点：
- 209.9ºC
- 折射率：
- 1.547
- 蒸汽压：
- 2.24E-07mmHg at 25°C
- 存储条件/存储方法：
- 库房通风低温干燥,与食品原料类分开存放
(R)-盐酸布比卡因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TK6080000
- CHEMICAL NAME :
- 2',6'-Pipecoloxylidide, 1-butyl-, D-(+)-
- CAS REGISTRY NUMBER :
- 27262-45-9
- LAST UPDATED :
- 199112
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C18-H28-N2-O
- MOLECULAR WEIGHT :
- 288.48
- WISWESSER LINE NOTATION :
- T6NTJ A4 BVMR B1 F1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 38 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3800 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 7900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 5500 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
31,273,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >120 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 26,78,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 26,78,1976
(R)-盐酸布比卡因 海关数据
中国海关编码：2933399090
- 概述：
- 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
