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- 2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮
2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮
2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮 基本信息
- 中文名称：
- 2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮
- 中文别名：
- 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-.α.-D-erythro-pentofuranosyl)
- 英文名称：
- 6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-
- 英文别名：
- 9H-Purine-6-thiol, 2-amino-9-(2-deoxy-.α.-D-erythro-pentofuranosyl)-;
alpha-2'-deoxythioguanosine;
2-Amino-9-(2-deoxy-α-D-erythro-pentofuranosyl)-1,9-dihydro-6H-purine-6-thione;
.alpha.-Tgdr;
6H-Purine-6-thione, 2-amino-9-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-1,9-dihydro-;
Aids159948;
Aids-159948;
Nsc71851;
Thioguanine 9.alpha.D-2'-deoxyriboside
- CAS No.：
- 2133-81-5
- 分 子 式：
- C10H13N5O3S
- 分 子 量：
- 0
- 精确分子量：
- 283.07400
- PSA：
- 154.30000
- InChI：
- The Key: SCVJRXQHFJXZFZ-UHFFFAOYSA-N
- 分子结构式：
-
- SDS：
- 查看
2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮 物化性质
- 密度：
- 2.02g/cm3
- 沸点：
- 709.1ºC at 760 mmHg
- 闪点：
- 382.6ºC
- 折射率：
- 1.93
- 蒸汽压：
- 4.22E-21mmHg at 25°C
2-氨基-9-[4-羟基-5-(羟基甲基)四氢呋喃-2-基]-3H-嘌呤-6-硫酮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UP0745000
- CHEMICAL NAME :
- 9H-Purine-6(1H)-thione,
2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-
- CAS REGISTRY NUMBER :
- 2133-81-5
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C10-H13-N5-O3-S
- MOLECULAR WEIGHT :
- 283.34
- WISWESSER LINE NOTATION :
- T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1 gm/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 1500 mg/kg/33D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Blood - leukopenia
Blood - thrombocytopenia
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 3 gm/kg/5D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Blood - agranulocytosis
Skin and Appendages - dermatitis, other (after systemic exposure)
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Cells - not otherwise specified
- DOSE/DURATION :
- 100 umol/kg
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
35,1103,1975
