替拉扎明

外观与性状：

橙色-红色结晶粉末

密度：

1.68 g/cm3

熔点：

220ºC

沸点：

493.6ºC at 760 mmHg

闪点：

252.3ºC

折射率：

1.777

蒸汽压：

0mmHg at 25°C

危险类别码：

36/37/38

安全说明：

26-36

RTECS号：

DM0671500

危险标志：

Xi: Irritant;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DM0671500

CHEMICAL NAME :

1,2,4-Benzotriazine, 3-amino-, 1,4-dioxide

CAS REGISTRY NUMBER :

27314-97-2

BEILSTEIN REFERENCE NO. :

0179322

LAST UPDATED :

199712

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C7-H6-N4-O2

MOLECULAR WEIGHT :

178.17

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

59390 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>36 mg/kg

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Endocrine - other changes Blood - changes in bone marrow (not otherwise specified)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

89 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

101 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Skin and Appendages - hair Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

19 mg/kg/2W-C

TOXIC EFFECTS :

Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

Unscheduled DNA synthesis

TEST SYSTEM :

Rodent - rat Mammary gland

DOSE/DURATION :

500 umol/L

REFERENCE :

CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 11,1407,1990

3-氨基-1,2,4-苯并噻嗪-1-n-氧化物 1,2,4-苯并噻嗪-3-胺 2-硝基苯胺 1,2-二硝基苯 3-氨基-1,2,4-苯并噻嗪-1-n-氧化物 1,2,4-苯并噻嗪-3-胺 2-硝基苯胺 1,2-二硝基苯

3-氨基-1,2,4-苯并噻嗪-1-n-氧化物 D-(+)-核糖酸-GAMMA-内酯 1,2,4-苯并噻嗪-3-胺 3-氨基-1,2,4-苯并噻嗪-1-n-氧化物 D-(+)-核糖酸-GAMMA-内酯 1,2,4-苯并噻嗪-3-胺