荧光增白剂24

CHEMICAL IDENTIFICATION

RTECS NUMBER :

GD0300400

CHEMICAL NAME :

C.I. Fluorescent Brightening Agent 24

CAS REGISTRY NUMBER :

12224-02-1

LAST UPDATED :

199709

DATA ITEMS CITED :

10

MOLECULAR FORMULA :

C40-H40-N12-O16-S4.4Na

MOLECULAR WEIGHT :

1165.12

WISWESSER LINE NOTATION :

T6N CN ENJ BN2Q2Q DMR DSWO FMR CSWO D1U1R BSWO DM- BT6N CN ENJ DN2Q2Q FMR CSWO &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued. Volume(issue)/page/year: 2,193,1973

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued. Volume(issue)/page/year: 2,193,1973 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1960 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued. Volume(issue)/page/year: 2,193,1973

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1620 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),87,1986

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued. Volume(issue)/page/year: 2,193,1973

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

MVCRB3 MVC-Report. (Stockholm, Sweden) No.1-2, 1972-73. Discontinued. Volume(issue)/page/year: 2,193,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

13800 mg/kg/30D-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Liver - liver function tests impaired Blood - change in clotting factors

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 51(1),88,1986

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:8

3.氢键受体数量:28

4.可旋转化学键数量:20

5.互变异构体数量:81

6.拓扑分子极性表面积:475

7.重原子数量:74

8.表面电荷:-2

9.复杂度:1960

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:1

14.不确定化学键立构中心数量:0

15.共价键单元数量:3