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卡马西泮
- 基本信息
- 制备方法及用途
- 物化性质
- 安全信息
- 毒理性
- 下游产品
卡马西泮 基本信息
- 中文名称：
- 卡马西泮
- 中文别名：
- 卡马西泮
- 英文名称：
- Carbamic acid,N,N-dimethyl-,7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl ester
- 英文别名：
- (7-chloro-1-methyl-2-oxo-5-phenyl-3H-1,4-benzodiazepin-3-yl) N,N-dimethylcarbamate;
Limpidon;
Paxor;
Nebolan;
7-chloro-1-methyl,5-phenyl,3-dimethylcarbamoyloxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one;
Panevril;
Camazepamum [INN-Latin];
Albego;
Camazepam;
DEA No. 2749;
7-chloro-3-dimethylcarbamoyloxy-1-methyl-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one;
Camazepam (INN)
- CAS No.：
- 36104-80-0
- 分 子 式：
- C19H18ClN3O3
- 分 子 量：
- 371.85
- 精确分子量：
- 371.10400
- PSA：
- 62.21000
- EINECS：
- 252-866-6
- InChI：
- The Key: PXBVEXGRHZFEOF-UHFFFAOYSA-N
- 安全术语：
- Moderately toxic by ingestion and intraperitoneal routes. A tranquilizer. See also CARBAMATES and DIAZEPAM. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
卡马西泮 制备方法及用途
制备方法
由7-氯-5-苯基-1-甲基-3-羟基-1,3-二氢-2H-1,4-苯并二氮杂 -2-酮经与氯甲酸苯酯缩合、与二甲胺置换而得。
用途简介
用作安定药和抗抑郁药。小鼠口服LD50为970毫克/公斤,大鼠LD50大于4000毫克/公斤。
卡马西泮 物化性质
- 密度：
- 1.29g/cm3
- 沸点：
- 568.3ºC at 760mmHg
- 闪点：
- 297.5ºC
- 折射率：
- 1.618
- 存储条件/存储方法：
- 库房低温通风干燥
卡马西泮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EZ9033500
- CHEMICAL NAME :
- Carbamic acid, dimethyl-,
7-chloro-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-
benzodiazepin-3-yl ester
- CAS REGISTRY NUMBER :
- 36104-80-0
- BEILSTEIN REFERENCE NO. :
- 0715180
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C19-H18-Cl-N3-O3
- MOLECULAR WEIGHT :
- 371.85
- WISWESSER LINE NOTATION :
- T67 GNV JN IHJ CG G1 IOVN1&1 KR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,2029,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 970 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,2032,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 24,2032,1974
