1,2,4,5-四氯苯

外观与性状：

白色晶体

密度：

1.858

熔点：

139 °C

沸点：

240-246 °C(lit.)

闪点：

>230 °F

水溶解性：

insoluble.

折射率：

1.582

存储条件/存储方法：

库房通风低温干燥,与氧化剂、食品添加剂分开存放

稳定性相关：

1.稳定性^[26]  稳定

2.禁配物^[27]  强氧化剂、强碱

3.避免接触的条件^[28]  受热

4.聚合危害^[29]  不聚合

5.分解产物^[30]  氯化氢

其它信息：

1.性状：白色薄片^[1]

2.熔点（℃）：139~142^[2]

3.沸点（℃）：243~246^[3]

4.相对密度（水=1）：1.73（10℃）^[4]

5.相对蒸气密度（空气=1）：7.4^[5]

6.饱和蒸气压（kPa）：＜0.013（25℃）^[6]

7.临界温度（℃）：489.8^[7]

8.临界压力（MPa）：3.38^[8]

9.辛醇/水分配系数：4.64^[9]

10.闪点（℃）：155（CC）^[10]

11.溶解性：不溶于水，微溶于乙醇，溶于苯、乙醚和氯仿。^[11]

12.蒸气压的温度（ºC,5.33kPa）：146

13.蒸气压的温度（ºC,8.0kPa）：157.7

14.蒸气压的温度（ºC,13.3kPa）：173.5

15.蒸气压的温度（ºC,26.7kPa）：196

16.蒸气压的温度（ºC,53.3kPa）：220.3

17.蒸气压的温度（ºC,101.3kPa）：245

18.气相标准熵(J·mol^-1·K^-1) ：393.60

19.气相标准热熔(J·mol^-1·K^-1)：144.79

包装等级：

I; II; III

风险类别：

6.1

海关代码：

29036990

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R22;R36/37/38

安全说明：

S26-S36-S45-S27-S16

RTECS号：

DB9450000

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。

危险标志：

Xn:Harmful;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

DB9450000

CHEMICAL NAME :

Benzene, 1,2,4,5-tetrachloro-

CAS REGISTRY NUMBER :

95-94-3

BEILSTEIN REFERENCE NO. :

1618315

LAST UPDATED :

199712

DATA ITEMS CITED :

19

MOLECULAR FORMULA :

C6-H2-Cl4

MOLECULAR WEIGHT :

215.88

WISWESSER LINE NOTATION :

GR BG DG EG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1500 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 30(1-3),8,1965

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1035 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

REFERENCE :

HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year: 30(1-3),8,1965

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 4,107,1952

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1500 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5460 mg/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - other changes in urine composition Blood - pigmented or nucleated red blood cells

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB91-185330

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

896 mg/kg/28D-C

TOXIC EFFECTS :

Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :

JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 11,663,1983

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2700 mg/kg/90D-C

TOXIC EFFECTS :

Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :

DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 7,113,1984

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4567 mg/kg/9W-I

TOXIC EFFECTS :

Endocrine - changes in adrenal weight Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12 mg/kg/35W-I

TOXIC EFFECTS :

Behavioral - alteration of classical conditioning Liver - changes in liver weight

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2100 mg/kg/14D-C

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Related to Chronic Data - death

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3126

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4550 mg/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Blood - microcytosis with or without anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :

NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NIH-91-3126

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

12 mg/kg/35W-I

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - changes in other cell count (unspecified)

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 30(1),9,1965

毒理学数据：

1.急性毒性^[20]  LD50：1500mg/kg（大鼠经口）

2.刺激性  暂无资料

3.亚急性与慢性毒性^[21]  兔吸入含20%四氯苯（浓度为4~5g/m³或8~10g/m³）粉末1~17天，导致红细胞和血红蛋白降低，淋巴细胞增高。以0.005mg/kg饲喂大鼠，条件反射活动改变，血清中巯基含量降低，肝功能轻度失调。

生态数据：

1.生态毒性^[22] 

LC50：4.35mg/L（48h），1.55mg/L（96h）（蓝鳃太阳鱼）；26.4mg/L（48h）（青鳉）

2.生物降解性^[23]

好氧生物降解（h）：672~4320

厌氧生物降解（h）：2880~17280

3.非生物降解性^[24]

空气中光氧化半衰期（h）：763.1~7631

一级水解半衰期（h）：＞879a

4.生物富集性^[25] 

BCF：2720~4830（鲤鱼，接触浓度10ppb，接触时间8周）；1650~3930（鲤鱼，接触浓度1ppb，接触时间8周）

分子结构数据

1、摩尔折射率：45.83

2、摩尔体积（cm³/mol）：137.2

3、等张比容（90.2K）：350.7

4、表面张力（dyne/cm）：42.6

5、介电常数：

6、偶极距（10^-24cm³）：

7、极化率：18.16

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:10

8.表面电荷:0

9.复杂度:90.3

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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  5-四氯苯质谱(MS)
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