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娃兒藤鹼 基本信息
- 中文名称：
- 娃兒藤鹼
- 中文别名：
- 娃兒藤鹼
- 英文名称：
- Dibenzo[f,h]pyrrolo[1,2-b]isoquinoline,9,11,12,13,13a,14-hexahydro-2,3,5,6-tetramethoxy-, (13aR)-
- 英文别名：
- Tylocrebrine;
Tylocerebrine;
[13aR,(+)]-9,11,12,13,13a,14-Hexahydro-2,3,5,6-tetramethoxydibenzo[f,h]pyrrolo[1,2-b]isoquinoline;
(-)-(R)-tylocrebrine;
Tylocrebrin;
Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline,9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy-,(R)-(9ci);
Dibenzo(F,H)pyrrolo(1,2-B)isoquinoline,9,11,12,13,13A,14-hexahydro-2,3,5,6-tetramethoxy;
Lylocrebrine;
Tylocrebine
- CAS No.：
- 6879-02-3
- 分 子 式：
- C24H27NO4
- 分 子 量：
- 0
- 精确分子量：
- 393.19400
- PSA：
- 40.16000
- InChI：
- The Key: YFEPHJVWLFGWKH-CQSZACIVSA-N
- 分子结构式：
-
- SDS：
- 查看
娃兒藤鹼 物化性质
- 密度：
- 1.26g/cm3
- 沸点：
- 559.9ºC at 760 mmHg
- 闪点：
- 160.5ºC
- 折射率：
- 1.657
- 蒸汽压：
- 1.44E-12mmHg at 25°C
娃兒藤鹼 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP0175000
- CHEMICAL NAME :
- Tylocrebrine
- CAS REGISTRY NUMBER :
- 6879-02-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C24-H27-N-O4
- MOLECULAR WEIGHT :
- 393.52
- WISWESSER LINE NOTATION :
- T D5 B6 K666 DNJ MO1 NO1 RO1 SO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 65 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Gastrointestinal - hypermotility, diarrhea
Skin and Appendages - hair
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 32 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg/24D-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of esophagus
Gastrointestinal - ulceration or bleeding from large intestine
Blood - other changes
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 24 mg/kg/24D-I
- TOXIC EFFECTS :
- Liver - other changes
Blood - pigmented or nucleated red blood cells
Blood - changes in erythrocyte (RBC) count
- REFERENCE :
- NCICP* Progress Report Submitted to the National Cancer Institute by Charles
Pfizer & Co. Volume(issue)/page/year: -,77,1964
