4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸

  • 基本信息
  • 物化性质
  • 毒理性

4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸 基本信息

中文名称:
4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸 
中文别名:
4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸 
英文名称:
1-Piperazineethanol,4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]-, hydrochloride (1:2)
英文别名:
Oxypendyl dihydrochloride;
perthipendyl,dihydrochloride;
2-[4-(3-benzo[b]pyrido[2,3-e][1,4]thiazin-10-yl-propyl)-piperazin-1-yl]-ethanol,dihydrochloride;
Pervetral;
4-[3-(10H-pyrido[3,2-b][1,4]benzothiazin-10-yl)propyl]piperazine-1-ethanol dihydrochloride;
1-Piperazineethanol,4-[3-(10H-pyrido[3,2-B][1,4]benzothiazin-10-yl)propyl]-,dihydrochloride;
oxypendyl,dihydrochloride;
Pervetral dihydrochloride 
CAS No.:
17297-82-4
分 子 式:
C20H26N4OS.2ClH
分 子 量:
443.48
精确分子量:
406.15900
PSA:
68.14000
InChI:
The Key: VGYCFAGKTGBWJD-UHFFFAOYSA-N
危险品标志:
Moderately toxic by ingestion.
安全术语:
A poison by intravenous, intraperitoneal and subcutaneous routes. Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NOx, SOx, and Cl−.
分子结构式:
SDS:
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4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸 物化性质

密度:
1.22g/cm3
沸点:
575.5ºC at 760mmHg
闪点:
301.8ºC
蒸汽压:
4.39E-14mmHg at 25°C

4-[3-(10H-吡啶并[3,2-b][1,4]苯并噻嗪-10-基)丙基]哌嗪-1-乙醇二盐酸 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9450000
CHEMICAL NAME :
1-Piperazineethanol, 4-(3-(10H-pyrido(3,2-b)(1,4)benzothiazin-10-yl)propyl )-, dihydrochloride
CAS REGISTRY NUMBER :
17297-82-4
LAST UPDATED :
199012
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C20-H26-N4-O-S.2Cl-H
MOLECULAR WEIGHT :
443.48
WISWESSER LINE NOTATION :
T C666 BS DN INJ I3- AT6N DNTJ D2Q &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1610 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,273,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,273,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
735 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,273,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
139 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,435,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
352 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,273,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,273,1972

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