产品供求
普罗喹宗
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 海关数据
- 上游产品
普罗喹宗 基本信息
- 中文名称：
- 普罗喹宗
- 中文别名：
- 普罗喹宗
- 英文名称：
- 2(1H)-Quinazolinone,7-methyl-1-(1-methylethyl)-4-phenyl-
- 英文别名：
- 7-methyl-4-phenyl-1-propan-2-ylquinazolin-2-one;
EINECS 245-203-7;
Sandoz 43-715;
7-methyl-1-isopropyl-4-phenyl-quinazolin-2(1H)-one;
Proquazonum [INN-Latin];
1-Isopropyl-4-phenyl-7-methyl-2(1H)-quinazolinone;
7-methyl-1-isopropyl-4-phenyl-2(1H)-quinazolinone;
Biarison;
1-isopropyl-7-methyl-4-phenyl-quinazolin-2(1H)-one;
PROQUAZONE;
1-isopropyl-7-methyl-4-phenyl-1H-quinazolin-2-one;
Proquazona [INN-Spanish];
SaH 43-715;
Arthrex
- CAS No.：
- 22760-18-5
- 分 子 式：
- C18H18N2O
- 分 子 量：
- 294.38
- 精确分子量：
- 278.14200
- PSA：
- 34.89000
- EINECS：
- 245-203-7
- InChI：
- The Key: JTIGKVIOEQASGT-UHFFFAOYSA-N
- 安全术语：
- Poison by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
普罗喹宗 物化性质
- 密度：
- 1.12g/cm3
- 沸点：
- 440.6ºC at 760mmHg
- 闪点：
- 220.3ºC
- 折射率：
- 1.605
- 蒸汽压：
- 5.79E-08mmHg at 25°C
普罗喹宗 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VA3530000
- CHEMICAL NAME :
- 2(1H)-Quinazolinone, 1-isopropyl-7-methyl-4-phenyl-
- CAS REGISTRY NUMBER :
- 22760-18-5
- BEILSTEIN REFERENCE NO. :
- 0889725
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H18-N2-O
- MOLECULAR WEIGHT :
- 278.38
- WISWESSER LINE NOTATION :
- T66 BNVNJ BY1&1 ER& I1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 759 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 375 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - antipsychotic
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 930 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 339 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - somnolence (general depressed activity)
Behavioral - changes in motor activity (specific assay)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 34,879,1984
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >800 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 260 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - ptosis
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - antipsychotic
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9100 mg/kg/13W-C
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - pig
- DOSE/DURATION :
- 6916 mg/kg/26W-C
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in erythrocyte (RBC) count
Related to Chronic Data - death
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New
York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 3,361,1980
普罗喹宗 海关数据
中国海关编码：2933990090
- 概述：
- 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
