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基本信息
- 中文名称：
-
- 中文别名：
-
- 英文名称：
- 1,2-Ethanediamine,N1,N1-dimethyl-N2-phenyl-N2-(phenylmethyl)-, hydrochloride (1:1)
- 英文别名：
- N'-benzyl-N,N-dimethyl-N'-phenylethane-1,2-diamine,hydrochloride;
PHENBENZAMINE HYDROCHLORIDE;
2339 R.P. hydrochloride;
Compound 2339 RP;
Antergan hydrochloride;
N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,hydrochloride;
Phenbenzamine chloride;
N-Phenyl-N-benzyl-N',N'-dimethylethylenediamine hydrochloride;
N-benzyl-N',N'-dimethyl-N-phenyl-ethylenediamine,monohydrochloride;
N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Monohydrochlorid;
N-Benzyl-N',N'-dimethyl-N-phenyl-aethylendiamin,Hydrochlorid;
Corps 2339 R P
- CAS No.：
- 2045-52-5
- 分 子 式：
- C17H22N2.ClH
- 分 子 量：
- 290.87
- 精确分子量：
- 290.15500
- PSA：
- 6.48000
- InChI：
- The Key: AJCNOWKYMZKMFV-UHFFFAOYSA-N
- 安全术语：
- Poison by ingestion, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. Used as an antihistaminic agent. See also AMINES.
- 分子结构式：
-
- SDS：
- 查看
物化性质
- 外观与性状：
- 米色结晶粉末
- 熔点：
- 210 - 211ºC
- 沸点：
- 375.9ºC at 760 mmHg
- 闪点：
- 166.2ºC
- 蒸汽压：
- 7.52E-06mmHg at 25°C
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KV1925000
- CHEMICAL NAME :
- Ethylenediamine, N-benzyl-N',N'-dimethyl-N-phenyl-,
hydrochloride
- CAS REGISTRY NUMBER :
- 2045-52-5
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H22-N2.Cl-H
- MOLECULAR WEIGHT :
- 290.87
- WISWESSER LINE NOTATION :
- 1N1&2NR&1R &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 68,339,1942
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
Volume(issue)/page/year: 144,887,1950
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 325 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 15 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 93,210,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- PHREA7 Physiological Reviews. (American Physiological Soc., 9650 Rockville
Pike, Bethesda, MD 20814) V.1- 1921- Volume(issue)/page/year:
27,542,1947
