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氟骨三醇 基本信息
- 中文名称：
- 氟骨三醇
- 中文别名：
- 氟骨三醇
- 英文名称：
- Hexafluorocalcitriol
- 英文别名：
- (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;
calcitriol hexafluoride;
Fulstan;
Hornel,Fulstan;
Ro 23-4194;
Hornel;
ST-630;
falecalcitriol;
Flocalcitriol
- CAS No.：
- 83805-11-2
- 分 子 式：
- C27H38F6O3
- 分 子 量：
- 524.58
- 精确分子量：
- 524.27300
- PSA：
- 60.69000
- InChI：
- The Key: XPYGGHVSFMUHLH-UUSULHAXSA-N
- 分子结构式：
-
- SDS：
- 查看
氟骨三醇 物化性质
- 密度：
- 1.24 g/cm3
- 沸点：
- 576.9ºC at 760 mmHg
- 闪点：
- 302.7ºC
- 折射率：
- 1.504
氟骨三醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VS2886100
- CHEMICAL NAME :
- 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol,
26,26,26,27,27,27-hexafluoro-,
(1-alpha,3-beta,5Z,7E)-
- CAS REGISTRY NUMBER :
- 83805-11-2
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 8
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 41700 ng/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2695,1996
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2695,1996
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 55 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Nutritional and Gross Metabolic - body temperature decrease
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2695,1996
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 5 ug/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - respiratory stimulation
Gastrointestinal - nausea or vomiting
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2695,1996
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2700 ng/kg/90D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - urine volume increased
Nutritional and Gross Metabolic - changes in calcium
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2709,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1016 ng/kg/53W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - changes in calcium
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2759,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 26400 ng/kg/84D-I
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2739,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 29200 ng/kg/1Y-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 30,2791,1996
氟骨三醇 上游产品
(5Z,7E,20R)-1α,3β-bis[(tert-butyldimethylsilyl)oxy]-20-formylmethyl-9,10-seco-5,7,10(19)-pregnatriene
(4R)-4-((1R,3aS,7aR,E)-4-((Z)-2-((3S,5R)-3,5-bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)pentan-2-ol
湖北诺纳科技有限公司
- 产品介绍：
-
产品名称：氟骨三醇
Cas号：83805-11-2
纯度：99%
包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
价格：1.0元 - 25.0元
- 联系方式：
-
联系人：张经理
电话：027-59209883
手机：17386169806
上海吉至生化科技有限公司
- 产品介绍：
-
产品名称：氟骨三醇
Cas号：83805-11-2
纯度：95%
包装信息：1mgea
价格：8,182.0元
- 联系方式：
-
联系人：Shirley张
电话：021-57520831
手机：18116052675
甘肃皓天科技股份有限公司
- 产品介绍：
-
产品名称：氟骨化醇
Cas号：83805-11-2
纯度：98%
包装信息：1g,5g,10g,100g,1mg
价格：1.0元 - 1.0元
- 联系方式：
-
联系人：蒋小姐
电话：0943-6900332
手机：17789447501
济南美特斯盾医药科技有限公司
- 产品介绍：
-
产品名称：氟骨化醇
Cas号：83805-11-2
纯度：98%
包装信息：500g
价格：洽谈
- 联系方式：
-
联系人：程玥
电话：17753126471
手机：
彩迩文（上海）生化科技有限公司
- 产品介绍：
-
产品名称：氟骨三醇
Cas号：83805-11-2
纯度：
包装信息：洽谈
价格：洽谈
- 联系方式：
-
联系人：王东
电话：021-50790412
手机：
