盐酸平阳霉素

基本信息
物化性质
毒理性

盐酸平阳霉素基本信息

中文名称：: 盐酸平阳霉素

中文别名：: 盐酸平阳霉素;
(S,R)-1-(1-dimethylaminoethyl)-1,2-*bis(diphenyl;
1,2,3,4,5-cyclopentanepentayl, 1-[(1S)-1-(dimethylamino)ethyl]-2-(diphenylphosphino)-, compd. with 1-(diphenylphosphino)-1,2,3,4,5-cyclopentanepentayl, iron salt (1:1:1);
(S)-N,N-Dimethyl-1-[(R)-1',2-bis(diphenylphosphino)ferrocenyl]ethylamine;
(+)-(S)-N,N-dimethyl-1-((R)-2-(diphenyl-phosphino;
Tylmarin;
2-Propenoic acid, 3-(2-(acetyloxy)phenyl)- (9CI);
2-Acetoxycinnamic acid;
potassium salt of 6methyl-1,2,3-oxathiazin

英文名称：: Bleomycinamide,N1-[3-[(4-aminobutyl)amino]propyl]-, hydrochloride (1:?)

英文别名：: BLEOCIN(TM), STREPTOMYCES VERTICILLUS;
BLEOCIN(TM) ANTIBIOTIC;
n(sup1)-(3-((4-aminobutyl)amino)propyl)-bleomycinamidhydrochloride;
N1-[3-[(4-Aminobutyl)amino]propyl]bleomycinamide hydrochloride;
n(sup1)-(3-((4-aminobutyl)amino)propyl)bleomycinamidehydrochloride;
BleoMycin A5 Hydrochloride(PingyangMycin hydrochloride);
Bleomycin A5 Hydrochloride;
BLEOCIN(TM)

CAS No.：: 55658-47-4

分子式：: C₅₇H₈₉N₁₉O₂₁S₂.xClH

分子量：: 1477.02000

精确分子量：: 1475.57000

PSA：: 721.60000

InChI：: InChI=1/C57H89N19O21S2.ClH/c1-22-35(73-48(76-46(22)61)27(14-33(60)80)68-15-26(59)47(62)86)52(90)75-37(43(28-16-65-21-69-28)95-56-45(41(84)39(82)31(17-77)94-56)96-55-42(85)44(97-57(63)92)40(83)32(18-78)93-55)53(91)70-24(3)38(81)23(2)49(87)74-36(25(4)79)51(

分子结构式：

SDS：: 查看

盐酸平阳霉素物化性质

密度：: 1.56g/cm3

盐酸平阳霉素毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EC5990700

CHEMICAL NAME :: Bleomycinamide, N(sup 1)-(3-((4-aminobutyl)amino)propyl)-, hydrochloride

CAS REGISTRY NUMBER :: 55658-47-4

LAST UPDATED :: 199603

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C57-H89-N19-O21-S2.Cl-H

MOLECULAR WEIGHT :: 1477.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 67 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,363,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,175,1979 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg/8W-I

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in other cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 35 mg/kg/3W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Kidney, Ureter, Bladder - changes primarily in glomeruli

REFERENCE :: ANTBAL Antibiotiki. (Moscow, USSR) V.1-29, 1956-84. For publisher information, see AMBIEH. Volume(issue)/page/year: 24,847,1979

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 40 mg/kg/2W-I

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data - death