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N-二偶氮乙酰基甘氨酸酰肼 基本信息
- 中文名称：
- N-二偶氮乙酰基甘氨酸酰肼
- 中文别名：
-
- 英文名称：
- Glycine,N-(2-diazoacetyl)-, hydrazide
- 英文别名：
- (Z)-2-diazonio-1-[(2-hydrazinyl-2-oxoethyl)amino]ethenolate;
N-Diazoacetyl glycylhydrazide;
N-Diazoacetilglicina-idrazide;
N-Diazoacetyl glycyclhydrazide;
N-Diazoacetyl-glycin-hydrazid;
N-Diazoacetylglycine hydrazide;
Diazoacetylglycine hydrazide;
Diazoacetyl-aminoessigsaeurehydrazid
- CAS No.：
- 820-75-7
- 分 子 式：
- C4H7N5O2
- 分 子 量：
- 157.16
- 精确分子量：
- 157.06000
- PSA：
- 121.61000
- InChI：
- The Key: MOUDDNPBPJHZHZ-UHFFFAOYSA-N
- 安全术语：
- Poison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Mutation data reported. When heated to decomposition it emits toxic fumes including NOx.
- 分子结构式：
-
- SDS：
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N-二偶氮乙酰基甘氨酸酰肼 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- MB9450000
- CHEMICAL NAME :
- Glycine, N-(diazoacetyl)-, hydrazide
- CAS REGISTRY NUMBER :
- 820-75-7
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C4-H7-N5-O2
- MOLECULAR WEIGHT :
- 157.16
- WISWESSER LINE NOTATION :
- ZMV1UNN
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1335 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - emphysema
Behavioral - muscle contraction or spasticity
Gastrointestinal - hypermotility, diarrhea
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1595 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - cyanosis
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3852 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2575 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Liver - other changes
Kidney, Ureter, Bladder - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2985 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - emphysema
Cardiac - other changes
Gastrointestinal - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - nausea or vomiting
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 833 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - respiratory depression
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg/7D-I
- TOXIC EFFECTS :
- Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2100 mg/kg/7D-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight
Blood - changes in bone marrow (not otherwise specified)
Blood - changes in erythrocyte (RBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 780 mg/kg/20D-I
- TOXIC EFFECTS :
- Gastrointestinal - alteration in gastric secretion
Blood - hemorrhage
Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1080 mg/kg/10D-I
- TOXIC EFFECTS :
- Behavioral - food intake (animal)
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - proteinuria
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1200 mg/kg/4D-I
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg/4D-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Blood - leukemia
MUTATION DATA
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TEST SYSTEM :
- Rodent - mouse Fibroblast
- DOSE/DURATION :
- 2500 umol/L
- REFERENCE :
- JCROD7 Journal of Cancer Research and Clinical Oncology. (Springer-Verlag
New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.93-
1979- Volume(issue)/page/year: 94,7,1979
