二甲替嗪

  • 基本信息
  • 物化性质
  • 毒理性

二甲替嗪 基本信息

中文名称:
二甲替嗪 
中文别名:
二甲替嗪 
英文名称:
10H-Phenothiazine-2-sulfonamide,10-[2-(dimethylamino)propyl]-N,N-dimethyl-
英文别名:
10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide;
dimethothiazine;
FONAZINE;
Dimetiotazine;
Dimethodin;
10-(2-dimethylamino-propyl)-10H-phenothiazine-2-sulfonic acid dimethylamide;
Dimetotiazinum [INN-Latin];
N,N-Dimethyl-10-(2-dimethylaminopropyl)-phenothiazin-2-sulfonamide;
Dimetotiazine;
Dimetotiazine [INN:BAN];
Bayer 1483;
Dimetotiazina [INN-Spanish];
Dimetiotazin;
Dimethothiazin 
CAS No.:
7456-24-8
分 子 式:
C19H25N3O2S2
分 子 量:
391.557
精确分子量:
391.13900
PSA:
77.54000
EINECS:
231-229-6
InChI:
The Key: VWNWVCJGUMZDIU-UHFFFAOYSA-N
分子结构式:
SDS:
查看

二甲替嗪 物化性质

密度:
1.235g/cm3
沸点:
533.7ºC at 760 mmHg
闪点:
276.6ºC
折射率:
1.612

二甲替嗪 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP5250000
CHEMICAL NAME :
Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-
CAS REGISTRY NUMBER :
7456-24-8
LAST UPDATED :
199612
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C19-H25-N3-O2-S2
MOLECULAR WEIGHT :
391.59
WISWESSER LINE NOTATION :
T C666 BN ISJ B1Y1&N1&1 ESWN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
740 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
475 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 159,70,1966 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
600 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,381,1970

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