卡前列素氨基丁三醇; (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇

密度：

1.153g/cm3

沸点：

536.6ºC at 760 mmHg

闪点：

292.4ºC

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UK8026000

CAS REGISTRY NUMBER :

58551-69-2

LAST UPDATED :

198910

DATA ITEMS CITED :

7

MOLECULAR FORMULA :

C21-H36-O5.C4-H11-N-O3

MOLECULAR WEIGHT :

489.73

WISWESSER LINE NOTATION :

L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

25100 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

131 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intramuscular

DOSE :

30 ug/kg

SEX/DURATION :

female 14 week(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - abortion

REFERENCE :

CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 11,533,1975

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

87 ug/kg

SEX/DURATION :

female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

87 ug/kg

SEX/DURATION :

female 15-22 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition Reproductive - Fertility - abortion Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

6 mg/kg

SEX/DURATION :

male 3 day(s) pre-mating female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

300 ug/kg

SEX/DURATION :

female 9-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978