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- 雌三醇 16,17-二乙酸酯 3-苯甲酸酯
雌三醇 16,17-二乙酸酯 3-苯甲酸酯 基本信息
- 中文名称：
- 雌三醇 16,17-二乙酸酯 3-苯甲酸酯
- 中文别名：
-
- 英文名称：
- Estra-1,3,5(10)-triene-3,16,17-triol,16,17-diacetate 3-benzoate (9CI)
- 英文别名：
- [(16R,17R)-16,17-diacetyloxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decah ydrocyclopenta[a]phenanthren-3-yl] benzoate;
estriol benzoate diacetate;
Estriol 3-benzoate 16,17-diacetate;
Estriol acetate benzoate
- CAS No.：
- 2508-47-6
- 分 子 式：
- C29H32O6
- 分 子 量：
- 0
- 精确分子量：
- 476.22000
- PSA：
- 78.90000
- 分子结构式：
-
- SDS：
- 查看
雌三醇 16,17-二乙酸酯 3-苯甲酸酯 物化性质
- 密度：
- 1.24g/cm3
- 沸点：
- 578.9ºC at 760mmHg
- 闪点：
- 245.7ºC
- 折射率：
- 1.594
- 蒸汽压：
- 2.14E-13mmHg at 25°C
雌三醇 16,17-二乙酸酯 3-苯甲酸酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7730200
- CHEMICAL NAME :
- Estra-1,3,5(10)-triene-3,16-alpha,17-beta-triol,
3-benzoate, 16,17-diacetate
- CAS REGISTRY NUMBER :
- 2508-47-6
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C29-H32-O6
- MOLECULAR WEIGHT :
- 476.61
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 7,748,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1080 mg/kg/90D-I
- TOXIC EFFECTS :
- Blood - normocytic anemia
Nutritional and Gross Metabolic - weight loss or decreased weight gain
Related to Chronic Data - changes in ovarian weight
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 7,3355,1979
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
61,89s,1965
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 4500 ug/kg
- SEX/DURATION :
- female 9-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon
Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year:
61,89s,1965
