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- 托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水)
托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水)
托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水) 基本信息
- 中文名称：
- 托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水)
- 中文别名：
- 托美丁钠(二水);
托美丁钠二水;
2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水);
1-甲基-5-(P-甲苯酰基)吡咯-2-乙酸钠盐;
托美丁钠二水合物
- 英文名称：
- Sodium tolmetin dihydrate
- 英文别名：
- Tolmetin Sodium Salt Dihydrate;
sodium,2-[1-methyl-5-(4-methylbenzoyl)pyrrol-2-yl]acetate,dihydrate
- CAS No.：
- 64490-92-2
- 分 子 式：
- C15H18NNaO5
- 分 子 量：
- 315.30
- 精确分子量：
- 315.10800
- PSA：
- 80.59000
- InChI：
- InChI=1/C15H15NO3.Na.2H2O/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18;;;/h3-8H,9H2,1-2H3,(H,17,18);;2*1H2/q;+1;;
- 危险品标志：
- 风险术语：
- R22;R38
- 安全术语：
- S36
- 分子结构式：
-
- SDS：
- 查看
托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水) 物化性质
- 外观与性状：
- 结晶固体
- 熔点：
- 155-157 (dec.)
- 沸点：
- 483.2ºC at 760 mmHg
- 闪点：
- 246ºC
托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水) 安全信息
- WGK_Germany：
- 3
德国有关水污染物质的分类清单
- 危险类别码：
- R22;R38
- 安全说明：
- S36
- RTECS号：
- UX9280000
- 危险标志：
- Xn: Harmful;
托美丁钠(二水); 2-[1-甲基-5-(4-甲基苯甲酰)吡咯-2-基]乙酸钠(二水) 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UX9280000
- CHEMICAL NAME :
- 1H-Pyrrole-2-acetic acid,
1-methyl-5-(4-methylbenzoyl)-, sodium salt, dihydrate
- CAS REGISTRY NUMBER :
- 64490-92-2
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C15-H14-N-O3.Na.2H2-O
- MOLECULAR WEIGHT :
- 315.33
- WISWESSER LINE NOTATION :
- T5NJ A1 BVR D1& E1VO &-NA- &QH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 914 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #134763
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 612 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #134763
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1050 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1099,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >724 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Blood - changes in spleen
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1099,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 899 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #134763
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #134763
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 670 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Gastrointestinal - ulceration or bleeding from stomach
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1099,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >622 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from large intestine
Blood - changes in spleen
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1099,1977
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9360 mg/kg/26W-I
- TOXIC EFFECTS :
- Gastrointestinal - other changes
Endocrine - adrenal cortex hyperplasia
Blood - changes in cell count (unspecified)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1117,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3720 mg/kg/31D-I
- TOXIC EFFECTS :
- Endocrine - changes in spleen weight
Blood - pigmented or nucleated red blood cells
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 11,1107,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43800 mg/kg/2Y-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Blood - normocytic anemia
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 30,557,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33306 mg/kg/78W-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Blood - normocytic anemia
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 30,557,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 134 gm/kg/1Y-I
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Blood - normocytic anemia
- REFERENCE :
- YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo,
Japan) V.1- 1950- Volume(issue)/page/year: 30,557,1979
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 163 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 8,158,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1300 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 8,158,1977
上海吉至生化科技有限公司
- 产品介绍：
-
产品名称：托美丁钠二水
Cas号：64490-92-2
纯度：99%
包装信息：100mgea
价格：498.0元
- 联系方式：
-
联系人：江珊
电话：021-57520831
手机：15316869680
张家港华茂精细化学有限公司
- 产品介绍：
-
产品名称：托美丁钠（二水）
Cas号：64490-92-2
纯度：98%
包装信息：1kg
价格：洽谈
- 联系方式：
-
联系人：倪
电话：13921961611
手机：13962221965
湖北鑫鸣泰化学有限公司
- 产品介绍：
-
产品名称：托美丁钠(二水)
Cas号：64490-92-2
纯度：98%
包装信息：25/桶kg
价格：1.0元
- 联系方式：
-
联系人：黄经理
电话：027-51833411
手机：13237166274
湖北江民泰华化工有限公司
- 产品介绍：
-
产品名称：托美丁钠(二水)
Cas号：64490-92-2
纯度：99%
包装信息：25kg,200kg
价格：洽谈
- 联系方式：
-
联系人：张经理
电话：13396038321
手机：13396038321
湖北恩星生物科技有限公司
- 产品介绍：
-
产品名称：托美丁钠(二水)
Cas号：64490-92-2
纯度：
包装信息：100kg,200kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：邵经理
电话：16621771607
手机：16621771607
西安柏思远医药科技有限公司
- 产品介绍：
-
产品名称：托美丁钠二水
Cas号：64490-92-2
纯度：98%
包装信息：1kg,2kg,300kg,400kg,500kg
价格：64.0元 - 100.0元
- 联系方式：
-
联系人：王女士
电话：029-68815808
手机：15934848600
武汉福德化工有限公司
- 产品介绍：
-
产品名称：托美丁钠（二水）
Cas号：64490-92-2
纯度：
包装信息：桶kg
价格：洽谈
- 联系方式：
-
联系人：刘雅倩
电话：027-83855392
手机：15827396479
斯百全化学（上海）有限公司
- 产品介绍：
-
产品名称：托美丁钠(二水)
Cas号：64490-92-2
纯度：
包装信息：洽谈
价格：洽谈
- 联系方式：
-
联系人：spectrum china sales
电话：021-67601398
手机：18616765336
