首页产品供求市场行情现货直销公司信息
产品
产品 公司 求购 资讯 法规
English
  1. 您当前位置：
  2. 首页
  3. 产品数据
  4. 二溴甘露醇

二溴甘露醇

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • 海关数据
  • 结构与计算化学
  • 上游产品
  • 下游产品

二溴甘露醇 基本信息

中文名称：
二溴甘露醇 
中文别名：
二溴甘露醇;
1,6-二溴-1,6-二脱氧-D-甘露糖醇 
英文名称：
D-Mannitol,1,6-dibromo-1,6-dideoxy-
英文别名：
1,6-DIBROMO-1,6-DIDEOXY-D-MANNITOL;
myelobromol;
1.6-Dibrom-1.6-didesoxy-D-mannit;
dibromannit;
r54;
1.6-dibromo-1.6-dideoxy-D-mannitol;
dibromomannitol;
Mielobromol;
mieobromol;
1,6-dibromo-D-1,6-dideoxy-mannitol;
mitobronitol;
myebrol 
CAS No.：
488-41-5
分 子 式：
C6H12Br2O4
分 子 量：
308.00
精确分子量：
305.91000
PSA：
80.92000
EINECS：
207-676-8
InChI：
The Key: VFKZTMPDYBFSTM-KVTDHHQDSA-N
危险品标志：
风险术语：
45-22
安全术语：
Moderately toxic by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Questionable carcinogen with experimental carcinogenic and neoplastigenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of Br−.
分子结构式：
SDS：
查看

二溴甘露醇 制备方法及用途

制备方法

由D-甘露醇与氢溴酸反应得到二溴甘露醇: 将甘露醇溶解于氢溴酸,加热回流3h。加水稀释并降温至52℃,加入活性炭脱色。过滤,将滤液降温至20℃,搅拌下用碳酸氢钠调节pH1~2,冷冻后甩滤、水洗、氯仿洗涤,真空干燥后用甲醇重结晶、活性炭脱色精制而得成品。收率约36%。

合成制备方法

由D-甘露醇与氢溴酸反应得到二溴甘露醇:
将甘露醇溶解于氢溴酸,加热回流3h。加水稀释并降温至52℃,加入活性炭脱色。过滤,将滤液降温至20℃,搅拌下用碳酸氢钠调节pH1~2,冷冻后甩滤、水洗、氯仿洗涤,真空干燥后用甲醇重结晶、活性炭脱色精制而得成品。收率约36%。

用途简介

本品为抗肿瘤药物。

用途

本品为抗肿瘤药物。

二溴甘露醇 物化性质

密度：
2.117g/cm3
沸点：
511.2ºC at 760mmHg
闪点：
263ºC
折射率：
1.622
蒸汽压：
1.37E-12mmHg at 25°C
稳定性相关：

遇碱易分解,其水溶液能分解逸出氢溴酸。在干燥空气中稳定,无臭,味微苦。

其它信息：

1.       性状：白色结晶或结晶性粉末。

2.       熔点（ºC）：187。

3.       溶解性：易溶于浓氢溴酸及DMF。略溶于乙醇,微溶于水和丙酮。

二溴甘露醇 安全信息

海关代码：
2905590090
WGK_Germany：
3
德国有关水污染物质的分类清单
危险类别码：
45-22
RTECS号：
OP2800000
安全标志：
S22:不要吸入粉尘。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。
:
危险标志：
T: Toxic;

二溴甘露醇 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OP2800000
CHEMICAL NAME :
Mannitol, 1,6-dibromo-1,6-dideoxy-, D-
CAS REGISTRY NUMBER :
488-41-5
BEILSTEIN REFERENCE NO. :
1721919
LAST UPDATED :
199707
DATA ITEMS CITED :
36
MOLECULAR FORMULA :
C6-H12-Br2-O4
MOLECULAR WEIGHT :
308.00
WISWESSER LINE NOTATION :
E1YQYQYQYQ1E

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Blood - normocytic anemia Blood - thrombocytopenia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1240 mg/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - other changes Blood - normocytic anemia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1380 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1080 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4950 mg/kg/33D-I
TOXIC EFFECTS :
Behavioral - ataxia Liver - other changes Blood - changes in leukocyte (WBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5460 mg/kg/26W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - normocytic anemia Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
10920 mg/kg/26W-C
TOXIC EFFECTS :
Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9750 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7000 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - lymphoma, including Hodgkin's disease
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 9-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3900 mg/kg
SEX/DURATION :
female 26 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
3900 mg/kg
SEX/DURATION :
male 26 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
150 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
150 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
300 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Heritable translocation test
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Rodent - rabbit Bone marrow
DOSE/DURATION :
730 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 1(1),93,1971 TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

二溴甘露醇 海关数据

中国海关编码：2905590090

概述：
2905590090 其他无环醇的卤化、磺化等衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%
申报要素：
品名, 成分含量, 用途, 包装
摘要/Summary：
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

二溴甘露醇 分子结构与计算化学数据

分子结构数据

1、  摩尔折射率：57.47

2、  摩尔体积（cm3/mol）：183.4

3、  等张比容（90.2K）：477.7

4、  表面张力（dyne/cm）：45.9

5、  极化率（10-24cm3）：22.78

推荐供应商更多供应商>>

湖北诺纳科技有限公司
产品介绍：
产品名称：二溴甘露醇 Cas号：488-41-5 纯度：99% 包装信息：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶 价格：1.0元 - 25.0元
联系方式：
联系人：张经理 电话：027-59209883 手机：17386169806

淄博航宇生物科技发展有限公司
产品介绍：
产品名称：二溴甘露醇 Cas号：488-41-5 纯度：99% 包装信息：100kg 价格：洽谈
联系方式：
联系人：张经理 电话：15666366704 手机：15666366704

@2009-2026 洛克化工网 浙ICP备16009103号 版权声明

QQ: 2241752642
微信二维码
电话: 19906633110