1-甲基-5-苯基吡唑烷-3-酮

密度：

1.126g/cm3

折射率：

1.552

CHEMICAL IDENTIFICATION

RTECS NUMBER :

UQ8735000

CHEMICAL NAME :

3-Pyrazolidinone, 1-methyl-5-phenyl-

CAS REGISTRY NUMBER :

14776-37-5

BEILSTEIN REFERENCE NO. :

0641049

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C10-H12-N2-O

MOLECULAR WEIGHT :

176.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

890 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,426,1959 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

8400 mg/kg/28D-C

TOXIC EFFECTS :

Blood - leukopenia Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,426,1959

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

2240 mg/kg/30D-C

TOXIC EFFECTS :

Blood - changes in cell count (unspecified) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,426,1959