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嘧啶硝唑 基本信息
- 中文名称：
- 嘧啶硝唑
- 中文别名：
- 嘧啶硝唑;
阿扎硝唑;
甲硝咪胺嘧烯
- 英文名称：
- 2-Pyrimidinamine,4-[(1E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl]-
- 英文别名：
- 4-[(E)-2-(1-methyl-5-nitroimidazol-2-yl)ethenyl]pyrimidin-2-amine;
Nitromidine;
4-((E)-2-(1-Methyl-5-nitro-1H-imidazol-2-yl)-ethenyl)-2-pyrimidinamine;
Triclose;
Azanidazol;
Azanidazole;
Azanidazolum [INN-Latin];
(E)-2-Amino-4-(2-(1-methyl-5-nitroimidazol-2-yl)vinyl)pyrimidine;
Azanidazol [INN-Spanish];
Azanidazolum
- CAS No.：
- 62973-76-6
- 分 子 式：
- C10H10N6O2
- 分 子 量：
- 246.26
- 精确分子量：
- 246.08700
- PSA：
- 116.17000
- 安全术语：
- Moderately toxic by intraperitoneal route. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
嘧啶硝唑 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV6261500
- CHEMICAL NAME :
- 2-Pyrimidinamine,
4-(2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl)-,
(E)-
- CAS REGISTRY NUMBER :
- 62973-76-6
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C10-H10-N6-O2
- MOLECULAR WEIGHT :
- 246.26
- WISWESSER LINE NOTATION :
- T6N CNJ BZ D1U1- BT5N CNJ A1 ENW
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 7600 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 860 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 5100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - irritability
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 162 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1430 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
MUTATION DATA
- TYPE OF TEST :
- Host-mediated assay
- TEST SYSTEM :
- Rodent - mouse Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 25 mmol/kg
- REFERENCE :
- DECRDP Drugs under Experimental and Clinical Research. (Bioscience
Ediprint, Blvd. James-Fazy 13, 1201 Geneva 1, Switzerland) V.1- 1977-
Volume(issue)/page/year: 11,755,1985
