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- 1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷 基本信息
- 中文名称：
- 1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷
- 中文别名：
- 1-[p-氯二苯基甲基]-4-甲基-1,4-二氮杂环庚烷 双盐酸盐;
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷;
高氯环秦 二盐酸盐
- 英文名称：
- 1H-1,4-Diazepine,1-[(4-chlorophenyl)phenylmethyl]hexahydro-4-methyl-, hydrochloride (1:2)
- 英文别名：
- 1-[P-CHLORODIPHENYLMETHYL]-4-METHYL-1,4-DIAZACYCLOHEPTANE DIHYDROCHLORIDE;
homochlorocyclizine,dihydrochloride;
HOMOCHLORCYCLIZINE DIHYDROCHLORIDE;
Homochlorcylizine;
sa97dihydrochloride
- CAS No.：
- 1982-36-1
- 分 子 式：
- C19H23ClN2.2ClH
- 分 子 量：
- 387.81
- 精确分子量：
- 386.10800
- PSA：
- 6.48000
- InChI：
- The Key: BDIJPBVLZALCFW-UHFFFAOYSA-N
- 危险品标志：
- 风险术语：
- 20/21/22
- 安全术语：
- Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
- 分子结构式：
-
- SDS：
- 查看
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷 物化性质
- 密度：
- 1.122g/cm3
- 沸点：
- 403.9ºC at 760mmHg
- 闪点：
- 198.1ºC
- 蒸汽压：
- 9.82E-07mmHg at 25°C
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷 安全信息
- 危险类别码：
- R20/21/22
- 安全说明：
- S36
- 危险标志：
- Xn: Harmful;
1-(对氯二苯基甲基)-4-甲基-1,4-二氮杂环庚烷 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HM3675000
- CHEMICAL NAME :
- 1H-1,4-Diazepine,
1-(p-chloro-alpha-phenylbenzyl)hexahydro-4-methyl-,
dihydrochloride
- CAS REGISTRY NUMBER :
- 1982-36-1
- LAST UPDATED :
- 199009
- DATA ITEMS CITED :
- 14
- MOLECULAR FORMULA :
- C19-H23-Cl-N2.2Cl-H
- MOLECULAR WEIGHT :
- 387.81
- WISWESSER LINE NOTATION :
- T7N DNTJ AYR&R DG& D1 &GH 2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 490 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 36 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory stimulation
Behavioral - tremor
Behavioral - excitement
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - ataxia
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 47 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - excitement
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - ataxia
Gastrointestinal - nausea or vomiting
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - muscle contraction or spasticity
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 390 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 76 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher
information, see JACIBY. Volume(issue)/page/year: 31,237,1960
