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佐柔比星 基本信息
- 中文名称：
- 佐柔比星
- 中文别名：
- 佐柔比星;
正定苯酰肼
- 英文名称：
- Benzoic acid,2-[1-[(2S,4S)-4-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide
- 英文别名：
- N-[(E)-1-[(2S,4S)-4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide;
Rubidazone;
ZORUBICIN;
Zorubicina [INN-Spanish];
zorubicine;
Benzoylhydrazone daunorubicin;
Zorubicin [INN];
daunomycin benzoylhydrazone;
Zorubicine [INN-French];
Rubidazon;
Zorubicinum [INN-Latin]
- CAS No.：
- 54083-22-6
- 分 子 式：
- C34H35N3O10
- 分 子 量：
- 645.66
- 精确分子量：
- 645.23200
- PSA：
- 210.23000
- InChI：
- The Key: FBTUMDXHSRTGRV-BJISBDEGSA-N
- 分子结构式：
-
- SDS：
- 查看
佐柔比星 物化性质
- 外观与性状：
- 白色或近乎于白色结晶粉末
- 密度：
- 1.54g/cm3
佐柔比星 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DG3345000
- CHEMICAL NAME :
- Benzoic acid,
(1-(4-((3-amino-2,3,6-trideoxy-alpha,L-lyxo-hexopyran
osyl)oxy)-1,2,3,4,6,1 1-
hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na
phthacenyl)ethylidene )hydrazide, (2S-cis)-
- CAS REGISTRY NUMBER :
- 54083-22-6
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C34-H35-N3-O10
- MOLECULAR WEIGHT :
- 645.72
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22500 ug/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 42500 ug/kg/5D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rat Cells - not otherwise specified
- DOSE/DURATION :
- 2150 ug/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
38,167,1989
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X2089
No. of Facilities: 8 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 229 (estimated)
No. of Female Employees: 82 (estimated)
