多亚甲基多苯基多异氰酸酯

外观与性状：

暗棕色液体带有一种弱气味

密度：

1.2 g/mL at 25ºC(lit.)

沸点：

392ºC5 mm Hg

闪点：

>230 °F

折射率：

n20/D 1.634

存储条件/存储方法：

贮存在阴凉、干燥、通风的库房内，远离火种、热源。严格防水、防潮，避免光照。

稳定性相关：

常温常压下稳定，避免强氧化剂

其它信息：

1.       性状：褐色透明液体，有刺激性气味

2.       密度（g/mL at 25°C）：1.2

3.       相对蒸汽密度（g/mL,空气=1）：8.6

4.       熔点（ºC）：未确定

5.       沸点（ºC,常压）：未确定

6.       沸点（ºC,5mmHg）：392

7.       折射率（n20/D）：1.634

8.       闪点（ºC）：>110

9.       比旋光度（º）：未确定

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（mmHg,37ºC）：未确定

12.    饱和蒸气压（kPa,114.4 ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（MPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：未确定

包装等级：

II

风险类别：

6.1

海关代码：

3909301000

危险类别码：

R20

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S28:接触皮肤之后，立即使用大量皂液洗涤。
S38:在通风不良的场所，佩戴合适的呼吸装置。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。

危险标志：

Xn: Harmful;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TR0350000

CHEMICAL NAME :

Polymethylenepolyphenyl isocyanate

CAS REGISTRY NUMBER :

9016-87-9

LAST UPDATED :

199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

49 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0516728

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

490 mg/m3/4H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Lungs, Thorax, or Respiration - respiratory depression Blood - hemorrhage

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555284

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

>9400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS0517028 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

15 mg/m3/2W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - changes in lung weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12 mg/m3/13W-I

TOXIC EFFECTS :

Related to Chronic Data - death

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 ** TUMORIGENIC DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6 mg/m3/6H/2Y-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

REFERENCE :

NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0525557 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,303,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84716 No. of Facilities: 367 (estimated) No. of Industries: 10 No. of Occupations: 14 No. of Employees: 2795 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84716 No. of Facilities: 2951 (estimated) No. of Industries: 59 No. of Occupations: 48 No. of Employees: 45703 (estimated) No. of Female Employees: 6250 (estimated)

毒理学数据：

皮肤/眼睛刺激数据：

兔子眼睛接触：100mg有轻度反应

急性毒性数据：

大鼠经口LD50：49mg/kg

大鼠吸收LC50：490mg/m3/4H

兔子皮肤接触LD：>9400mg/kg

其它多计量数据：

大鼠吸收TCLo：15 mg/m3/2W-I肺，胸部或呼吸-肺的变化，总重量营养代谢-体重减轻，体重增加的相关慢性数据-死亡

大鼠吸收TCLo：12 mg/m3/13W-I有关慢性数据-死亡

致肿瘤数据：

大鼠吸入TCLo: 6 mg/m3/6H/2Y-I肺部，胸部或呼吸-肿瘤