氟满脲

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学

氟满脲 基本信息

中文名称:
氟满脲 
中文别名:
氟环脲;
氟满脲;
氟螨脲 
英文名称:
Benzamide,N-[[[4-[[[[(4-chlorophenyl)cyclopropylmethylene]amino]oxy]methyl]phenyl]amino]carbonyl]-2,6-difluoro-
英文别名:
flucycloxuron;
benzamide,n-(((4-(((((4-chlorophenyl)cyclopropylmethylene)amino)oxy)methyl)phe;
Flucycloxuron [iso];
A 1335;
1-{α-[(EZ)-4-chloro-α-cyclopropylbenzylideneaminooxy]-p-tolyl}-3-(2,6-difluorobenzoyl)urea (ratio 50–80% (E)- and 50–20% (Z)-isomers);
N-[[4-[[[(4-chlorophenyl)-cyclopropyl-methylidene]amino]oxymethyl]phen yl]carbamoyl]-2,6-difluoro-benzamide;
N-({4-[({[(Ξ)-(4-chlorophenyl)cyclopropylmethylidene]amino}oxy)methyl]phenyl}carbamoyl)-2,6-difluorobenzamide (ratio 50–80% (E)- and 50–20% (Z)-isomers);
N-[[[4-[[[[(4-chlorophenyl)cyclopropylmethylene]amino]oxy]methyl]phenyl]amino]carbonyl]-2,6-difluorobenzamide;
Benzamide,N-(((4-(((((4-chlorophenyl)cyclopropylmethylene)amino)oxy)methyl)phenyl)amino)carbonyl)-2,6-difluoro 
CAS No.:
113036-88-7
分 子 式:

C25H20ClF2N3O3

分 子 量:
483.9011
精确分子量:
483.11600
PSA:
79.79000
MDL:
MFCD01632755
InChI:
The Key: PCKNFPQPGUWFHO-UHFFFAOYSA-N
危险品标志:

 

风险术语:

 

安全术语:
分子结构式:
SDS:
查看

氟满脲 制备方法及用途

制备方法

以对氯苯为原料,滴加γ-氯丁酰氯和氯苯的混合物,制得环丙基-4-氯苯酮。该化合物再与羟胺反应,得到相应的肟,该肟与4-硝基-2-苄基溴缩合、还原再与2,6-二氟苯甲异氰酸酯加成得氟螨脲。

合成制备方法

以对氯苯为原料,滴加γ-氯丁酰氯和氯苯的混合物,制得环丙基-4-氯苯酮。该化合物再与羟胺反应,得到相应的肟,该肟与4-硝基-2-苄基溴缩合、还原再与2,6-二氟苯甲异氰酸酯加成得氟螨脲。

用途简介

苯甲酰脲类杀螨剂、杀虫剂,属几丁质合成抑制剂。用于防治瘿螨和叶螨若虫,对成虫无作用。也可用于防治某些害虫的幼虫。

用途

苯甲酰脲类杀螨剂、杀虫剂,属几丁质合成抑制剂。用于防治瘿螨和叶螨若虫,对成虫无作用。也可用于防治某些害虫的幼虫。

氟满脲 物化性质

密度:
1.37 g/cm3
折射率:
1.625
其它信息:

1.性状:原药为灰色至黄色固体。

2.熔点(ºC):143.6

氟满脲 安全信息

包装等级:
III

氟满脲 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CV2467170
CHEMICAL NAME :
Benzamide, N-(((4-(((((4-chlorophenyl)cyclopropylmethylene)amino )oxy)methyl)phenyl)am ino) carbonyl)-2,6-difluoro-
CAS REGISTRY NUMBER :
113036-88-7
LAST UPDATED :
199501
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C25-H20-Cl-F2-N3-O3
MOLECULAR WEIGHT :
483.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,405,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,405,1991
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - duck
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,405,1991
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
3300 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,405,1991
毒理学数据:

大鼠经口LD50>5000mg/kg,经皮LD50>2000mg/kg,吸入LC503.3mg/L(4d)。动物试验未见致畸、致突变作用。虹鳟鱼LC50>100mg/L(96h),水蚤LC500.0044mg/L(48h),野鸭急性经口LD50>2000mg/kg,蜜蜂接触LD50>0.1mg/只。

氟满脲 MSDS


SECTION 1: Identification of the substance/mixture and of the company/undertaking
  Product identifiers
    Product name        : Flucycloxuron    
    REACH No.        : A registration number is not available for this substance as the substance    
    or its uses are exempted from registration, the annual tonnage does not
    require a registration or the registration is envisaged for a later
    registration deadline.
    CAS-No.        : 113036-88-7    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

SECTION 2: Hazards identification
  Classification of the substance or mixture
  Classification according to Regulation (EC) No 1272/2008
    Eye irritation (Category 2), H319
    Chronic aquatic toxicity (Category 4), H413
    For the full text of the H-Statements mentioned in this Section, see Section 16.
    In accordance with Annex I of Directive 67/548/EEC and its amendments, this substance does not need to
    be classified nor labelled.
  Label elements
  Labelling according Regulation (EC) No 1272/2008
    Pictogram
    Signal word        Warning    
    Hazard statement(s)
    H319        Causes serious eye irritation.    
    H413        May cause long lasting harmful effects to aquatic life.    
    Precautionary statement(s)
    P305 + P351 + P338        IF IN EYES: Rinse cautiously with water for several minutes. Remove    
    contact lenses, if present and easy to do. Continue rinsing.
    Supplemental Hazard        none    
    Statements
    Safety data sheet available on request.
  Other hazards - none

SECTION 3: Composition/information on ingredients
  Substances
    Synonyms        : N-[[[4-[[[[(4-    
    chlorophenyl)cyclopropylmethylene]amino]oxy]methyl]phenyl]amino]carb
    onyl]-2,6-difluorobenzamide
    Formula        : C25H20ClF2N3O3    
    Molecular Weight        : 483,89 g/mol    
    CAS-No.        : 113036-88-7    
    No components need to be disclosed according to the applicable regulations.
    For the full text of the H-Statements and R-Phrases mentioned in this Section, see Section 16

SECTION 4: First aid measures
  Description of first aid measures
  General advice
    Consult a physician. Show this safety data sheet to the doctor in attendance.
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
  In case of skin contact
    Wash off with soap and plenty of water. Consult a physician.
  In case of eye contact
    Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
  Most important symptoms and effects, both acute and delayed
    The most important known symptoms and effects are described in the labelling (see section 2.2) and/or in
    section 11
  Indication of any immediate medical attention and special treatment needed
    no data available

SECTION 5: Firefighting measures
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas, Hydrogen fluoride
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

SECTION 6: Accidental release measures
  Personal precautions, protective equipment and emergency procedures
    Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure
    adequate ventilation. Avoid breathing dust.
    For personal protection see section 8.
  Environmental precautions
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
    environment must be avoided.
  Methods and materials for containment and cleaning up
    Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
    containers for disposal.
  Reference to other sections
    For disposal see section 13.

SECTION 7: Handling and storage
  Precautions for safe handling
    Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
    Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
    protection.
    For precautions see section 2.2.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
  Specific end use(s)
    A part from the uses mentioned in section 1.2 no other specific uses are stipulated

SECTION 8: Exposure controls/personal protection
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
    at the end of workday.
  Personal protective equipment
  Eye/face protection
    Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
    and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    impervious clothing, The type of protective equipment must be selected according to the
    concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
    level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
    Use respirators and components tested and approved under appropriate government standards
    such as NIOSH (US) or CEN (EU).
  Control of environmental exposure
    Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into
    the environment must be avoided.

SECTION 9: Physical and chemical properties
  Information on basic physical and chemical properties
    a) Appearance        Form: powder    
    Colour: off-white
    b) Odour        characteristic    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        143,6 °C - Stable up to the melting point.    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evapouration rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        0,54 hPa at 25 °C    
    l) Vapour density        no data available    
    m) Relative density        no data available    
    n) Water solubility        practically insoluble    
    o) Partition coefficient: n- log Pow: 6,9 at 25 °C
    octanol/water
    p) Auto-ignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    Solubility in other        Ethanol 3,8 g/l at 20 °C    
    solvents

SECTION 10: Stability and reactivity
  Reactivity
    no data available
  Chemical stability
    Stable under recommended storage conditions.
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    no data available
  Incompatible materials
    no data available
  Hazardous decomposition products
    Other decomposition products - no data available
    In the event of fire: see section 5

SECTION 11: Toxicological information
  Information on toxicological effects
  Acute toxicity
    LD50 Oral - rat - > 5.000 mg/kg
    Inhalation: no data available
  Skin corrosion/irritation
    Skin - rabbit
    Result: No skin irritation
  Serious eye damage/eye irritation
    Eyes - rabbit
    Result: Mild eye irritation
  Respiratory or skin sensitisation
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    Did not show carcinogenic, teratogenic or mutagenic effects in animal experiments.
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Additional Information
    Repeated dose toxicity - rat - Feed - No observed adverse effect level - 120 mg/kg
    RTECS: Not available
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.

SECTION 12: Ecological information
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
  Other adverse effects
    no data available

SECTION 13: Disposal considerations
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
    professional waste disposal service to dispose of this material. Dissolve or mix the material with a
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
  Contaminated packaging
    Dispose of as unused product.

SECTION 14: Transport information
  UN number
    ADR/RID: -        IMDG: -        IATA: -    
  UN proper shipping name
    ADR/RID: Not dangerous goods
    IMDG: Not dangerous goods
    IATA:        Not dangerous goods    
  Transport hazard class(es)
    ADR/RID: -        IMDG: -        IATA: -    
  Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

SECTION 15: Regulatory information
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    For this product a chemical safety assessment was not carried out

SECTION 16: Other information
  Full text of H-Statements referred to under sections 2 and 3.
    H319        Causes serious eye irritation.    
    H413        May cause long lasting harmful effects to aquatic life.    
  Further information
    Copyright 2013 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

氟满脲 分子结构与计算化学数据

分子结构数据

1、  摩尔折射率:124.16

2、  摩尔体积(cm3/mol):350.8

3、  等张比容(90.2K):919.4

4、  表面张力(dyne/cm):47.1

5、  极化率(10-24cm3):49.22

计算化学数据

1.疏水参数计算参考值(XlogP):无

2.氢键供体数量:2

3.氢键受体数量:6

4.可旋转化学键数量:7

5.互变异构体数量:10

6.拓扑分子极性表面积79.8

7.重原子数量:34

8.表面电荷:0

9.复杂度:725

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:1

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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产品介绍:
产品名称:氟满脲 Cas号:113036-88-7 纯度:99% 包装信息:100kg 价格:100.0元
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产品名称:氟环脲 Cas号:113036-88-7 纯度: 包装信息:500kg,400kg,300kg,200kg,100kg 价格:64.0元 - 100.0元
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