三氯甲烷

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

三氯甲烷 基本信息

中文名称:
三氯甲烷 
中文别名:
氯仿;
哥罗仿,氯仿;
三氯甲烷 
英文名称:
Trichloromethane
英文别名:
chloroform;
SOLVENT MC;
HCC20;
r20;
TCM;
CHCl3;
freon20;
Chloroform;
trichloromethane;
Trichloromethane 
CAS No.:
67-66-3
分 子 式:

CHCl3

分 子 量:
119.38
精确分子量:
117.91400
PSA:
0.00000
MDL:
MFCD00000826
EINECS:
200-663-8
BRN:
1731042
InChI:
The Key: HEDRZPFGACZZDS-UHFFFAOYSA-N
危险品标志:


harmfulxntoxictflammablef

风险术语:

R45;R46;R11;R36/37/38:R23/24/25:R40;S36/37; S9;S16;S26;S36;S45;S36/37/39;

分子结构式:
SDS:
查看

三氯甲烷 制备方法及用途

制备方法

用作溶剂、氟里昂的原料,也用于塑料、医药、农药及香料等工业。

合成制备方法

1.三氯乙醛法(氯油法) 三氯乙醛(氯油)与氢氧化钙(或氢氧化钠)反应生成三氯甲烷,经冷凝水洗、沉淀、蒸馏,即得成品。

2.乙醛法 石灰水氯化得漂白液[Ca(ClO)2水溶液],与乙醛水溶液反应生成粗氯仿,经蒸馏得成品。

3.先将工业品氯仿用水洗涤至中性,静置,弃去上层水液。然后与工业品浓硫酸 (98%)以10 ∶ 1混合,搅拌洗涤至酸洗液呈淡咖啡色。每次洗涤要充分,并静置分层去除酸液。经酸洗后的氯仿用15%的碳酸钠溶液以10 ∶ 1比例混合,中和除酸至合格,静置后收集下层氯仿。最后加入少量工业无水碳酸钾进行蒸馏,收集中间馏出物 (61~62℃) ,即为成品。

4.甲醇法 甲醇法又称甲醇氢氯化/氯化法。甲醇法制三氯甲烷分两步进行,首先是甲醇催化氢氯化制一氯甲烷,然后一氯甲烷热氯化制三氯甲烷。工业装置分为氢氯化、氯化、精馏、汽化4个工序。

1)氢氯化工序 由甲醇和氯化氢为原料生产一氯甲烷的方法可采用液相催化和固相催化两种。液相催化法是在75%~80%的氯化锌水溶液催化剂作用下,在压力0.05MPa,温度140~145℃条件下,甲醇和氯化氢发生如下反应:

反应气中除生成有一氯甲烷、水和二甲醚外,还有未反应的甲醇和氯化氢。本工序采用冷凝和吸收相结合的方法,将反应生成的水及未反应的甲醇、氯化氢与一氯甲烷气体分离,再用碱中和剩下的氯化氢。然后,反应气经压缩、冷却和干燥除去水分。最后送氯化工序作原料。

2)氯化工序 氯气在400~450℃下与一氯甲烷发生下列反应:

改变氯气与一氯甲烷的比例,即可调节产物中氯化物的分布。工业装置通过控制氯比和低氯化物再循环来达到主产三氯甲烷的目的。

3)精馏工序 一氯甲烷氯化后,经冷凝得到粗氯化液,再采用4塔工艺流程处理。在初馏塔中除去低沸物(氯化氢、一氯甲烷、二氯甲烷)。在三氯精馏塔中,除去四氯化碳等高沸物,而从塔顶得到三氯甲烷产品。在中间蒸出塔及四氯精馏塔中,分别除去三氯甲烷和四氯乙烯等高沸物,在四氯精馏塔顶得到四氯化碳产品。

4)汽化工序 本工序的目的是将液氯加热汽化后送到氯化工序作为氯化反应的原料。

5.由四氯化碳还原制得,工业上还可用乙醇与次氯酸盐作用而得。

用途简介

用途

1.主要用于生产氟里昂(F-21、F-22、F-23)、染料和药物。医药上用作麻醉剂及天然或发酵药物的萃取剂,也可作为香料、油脂、树脂、橡胶的溶剂和萃取剂,与四氯化碳混合可制成不冻的防火液体。还可配制熏蒸剂,用作杀虫防霉剂的中间体。

2. 用作分析试剂,如作溶剂、色谱分析标准物质。还用于有机合成。

3.用于电子工业,常用作清洗去油剂。

4.用于有机合成,用作溶剂及麻醉剂等。[27]

三氯甲烷 物化性质

外观与性状:
无色透明重质液体,极易挥发,有特殊气味。
密度:
1.492 g/mL at 25 °C(lit.)
熔点:
-63 °C
沸点:
61 °C
闪点:
60.5-61.5°C
水溶解性:
8 g/L (20 ºC)
折射率:
n20/D 1.445(lit.)
蒸汽密度:
4.1 (vs air)
存储条件/存储方法:
2-8°C
稳定性相关:

1..稳定性[21]  稳定

2.禁配物[22]  碱类、铝

3.避免接触的条件[23]  灼热、光照

4.聚合危害[24]  不聚合

5.分解产物[25]  氯化氢

其它信息:

1.性状:无色透明重质液体,极易挥发,有特殊气味。[1]

2.熔点(℃):-63.5[2]

3.沸点(℃):61.3[3]

4.相对密度(水=1):1.5[4]

5.相对蒸气密度(空气=1):4.12[5]

6.饱和蒸气压(kPa):21.2(20℃)[6]

7.临界温度(℃):263.4[7]

8.临界压力(MPa):5.47[8]

9.辛醇/水分配系数:1.97[9]

10.溶解性:不溶于水,混溶于乙醇、乙醚、苯、丙酮、二硫化碳、四氯化碳。[10]

11.黏度(mPa·s,20ºC):0.563

12.相对密度(25℃,4℃):1.4797

13.常温折射率(n20):1.4459

14.蒸发热(KJ/mol,b.p.):247.0

15.熔化热(KJ/mol):9.55

16.生成热(KJ/mol,25ºC,液体):134.56

17.燃烧热(KJ/mol,25ºC,液体):402.23

18.比热容(KJ/(kg·K),20ºC):1.189

19.沸点上升常数:3.88

20.电导率(S/m,25ºC):<1×10-10

21.热导率(W/(m·K) ,20ºC):0.12997

22.体膨胀系数(K-1):0.001399

23.临界密度(g·cm-3):0.491

24.临界体积(cm3·mol-1):243

25.临界压缩因子:0.2691

26.偏心因子:0.213

27.Lennard-Jones参数(A):5.2751

28.Lennard-Jones参数(K):414.03

29.溶度参数(J·cm-3)0.5:19.028

30.van der Waals面积(cm2·mol-1):7.660×109

31.van der Waals体积(cm3·mol-1):43.500

32.气相标准声称热(焓)( kJ·mol-1) :-102.9

33.气相标准熵(J·mol-1·K-1) :295.61

34.气相标准生成自由能( kJ·mol-1):-70.1

35.气相标准热熔(J·mol-1·K-1):65.38

36.液相标准声称热(焓)( kJ·mol-1):-134.31

37.液相标准熵(J·mol-1·K-1) :202.9

38.液相标准生成自由能( kJ·mol-1):-73.93

39.液相标准热熔(J·mol-1·K-1):114.2

三氯甲烷 安全信息

包装等级:
III
风险类别:
6.1
海关代码:
2903130000
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R45:May cause cancer. R11:Highly Flammable. R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R36/37/38:Irritating to eyes, respiratory system and skin . R48/20/22:Harmful: danger of serious damage to health by prolonged exposure thro
安全说明:
S9-S16-S26-S36-S36/37-S45-S36/37/39-S25-S23-S53-S33-S7
RTECS号:
FS9100000
安全标志:
S7:保持容器紧密封闭。
S9:保持容器在一个有良好通风放的场所。
S16:远离火源。
S23:不要吸入蒸汽。
S25:避免接触眼睛。
S33:采取防护措施防止静电发生。
S36:穿戴合适的防护服装。
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
S53:避免暴露——使用前先阅读专门的说明。
:
:
危险标志:
Xn,F,T

三氯甲烷 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FS9100000
CHEMICAL NAME :
Chloroform
CAS REGISTRY NUMBER :
67-66-3
BEILSTEIN REFERENCE NO. :
1731042
LAST UPDATED :
199806
DATA ITEMS CITED :
139
MOLECULAR FORMULA :
C-H-Cl3
MOLECULAR WEIGHT :
119.37
WISWESSER LINE NOTATION :
GYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
2514 mg/kg
TOXIC EFFECTS :
Behavioral - muscle contraction or spasticity Cardiac - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
10 mg/m3/1Y
TOXIC EFFECTS :
Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting Gastrointestinal - other changes
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
25000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
5000 mg/m3/7M
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
546 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
908 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
47702 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
894 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
23 gm/m3/56M
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - general anesthetic Behavioral - changes in motor activity (specific assay)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
623 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
704 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
100 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Liver - liver function tests impaired
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
35 gm/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
59 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20000 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Amphibian - frog
DOSE/DURATION :
6 gm/m3
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
25000 ppm/5M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
840 mg/kg/28D-C
TOXIC EFFECTS :
Blood - changes in other cell count (unspecified)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7560 mg/kg/21D-I
TOXIC EFFECTS :
Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg/10D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 ppm/7H/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Liver - other changes Kidney, Ureter, Bladder - changes in bladder weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
90 ppm/6H/13W-I
TOXIC EFFECTS :
Liver - hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
300 ppm/6H/7D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Musculoskeletal - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1750 mg/kg/14D-C
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
12 ppm/6H/13W-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 ppm/6H/7D-I
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
25 ppm/7H/26W-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
85 ppm/7H/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
85 ppm/7H/26W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
13832 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
127 gm/kg/92W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
98 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Endocrine - thyroid tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
18 gm/kg/17W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7020 mg/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - Kidney tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
70 gm/kg/78W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors Endocrine - thyroid tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
24752 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
58968 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors Blood - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
130 gm/kg/2Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Liver - tumors Kidney, Ureter, Bladder - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1260 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
4 gm/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
30 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - gastrointestinal system Reproductive - Specific Developmental Abnormalities - homeostasis
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
300 ppm/7H
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
20100 ug/m3/1H
SEX/DURATION :
female 7-14 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2177 mg/kg
SEX/DURATION :
male 3 week(s) pre-mating female 3 week(s) pre-mating - 7 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2115 mg/kg
SEX/DURATION :
male 3 week(s) pre-mating female 3 week(s) pre-mating - 5 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/7H
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
100 ppm/7H
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
260 mg/kg
SEX/DURATION :
female 6-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
Mutation test systems - not otherwise specified
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sister chromatid exchange
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 11,243,1982 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 49 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,401,1979 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 20,401,1979 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,152,1987 TOXICOLOGY REVIEW ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,173,1974 TOXICOLOGY REVIEW AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 38,409,1965 TOXICOLOGY REVIEW FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR. Volume(issue)/page/year: 2,67,1973 TOXICOLOGY REVIEW DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,259,1978 TOXICOLOGY REVIEW BNYMAM Bulletin of the New York Academy of Medicine. (New York Academy of Medicine, 2 E. 103rd St., New York, NY 10029) Ser 2: V.1- 1925- Volume(issue)/page/year: 54,413,1978 TOXICOLOGY REVIEW CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 13,231,1978 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 50 ppm (240 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,14,1973 OSHA PEL (Gen Indu):CL 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 50 ppm (240 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 10 ppm (50 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 10 ppm (50 mg/m3);Carcinogen JAN 1993 OEL-AUSTRIA:TWA 10 ppm (50 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (49 mg/m3);Carcinogen JAN 1993 OEL-DENMARK:TWA 2 ppm (10 mg/m3);Carcinogen JAN 1993 OEL-FINLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm;Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 5 ppm (25 mg/m3);STEL 50 ppm (250 mg/m3);Carcinogen JAN 1993 OEL-GERMANY:TWA 10 ppm (50 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:STEL 10 mg/m3 JAN 1993 OEL-INDIA:TWA 10 ppm (50 mg/m3);Carcinogen JAN 1993 OEL-JAPAN:TWA 50 ppm (240 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (50 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-POLAND:TWA 50 mg/m3 JAN 1993 OEL-RUSSIA:TWA 50 ppm JAN 1993 OEL-SWEDEN:TWA 2 ppm (10 mg/m3);STEL 5 ppm (25 mg/m3);Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (50 mg/m3);STEL 20 ppm (100 mg/m3) JAN 1993 OEL-THAILAND:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-TURKEY:TWA 50 ppm (240 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (50 mg/m3);STEL 50 ppm (225 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROFORM-air:CA STEL 2 ppm/60M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO WASTE ANESTHETIC GASES AND VAPORS-air:CL 2 ppm/1H REFERENCE : MMWR** MMWR. Morbidity and Mortality Weekly Report. (Centers for Disease Control, Atlanta, GA 30333) V.25(10)- 1976- for RTECS citation, only V.34(Suppl 1S), 1985 is used. Volume(issue)/page/year: 37(S-7),28,1988 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18500 No. of Facilities: 5120 (estimated) No. of Industries: 78 No. of Occupations: 66 No. of Employees: 96747 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 18500 No. of Facilities: 4890 (estimated) No. of Industries: 65 No. of Occupations: 55 No. of Employees: 95773 (estimated) No. of Female Employees: 41397 (estimated)
毒理学数据:

1.急性毒性[11]

LD50:908mg/kg(大鼠经口)

LC50:47702mg/m3(大鼠吸入,4h)

2.刺激性[12]

家兔经皮:500mg(24h),轻度刺激。

家兔经眼:20mg(24h),中度刺激。

3.亚急性与慢性毒性[13]  大鼠吸入2ppm本品,每天7h,每周5d,共6个月,有肝和肾组织损伤。

4.致突变性[14]   DNA抑制:人Hela细胞19mmol/L。姐妹染色单体交换:人淋巴细胞10mmol/L。微核试验:大鼠经口4mmol/kg。程序外DNA合成:大鼠经口1g/kg。DNA损伤:人肺100μmol/L(3h)

5.致畸性[15]  大鼠孕后6~15d经口给予最低中毒剂量(TDLo)1260mg/kg,致肌肉骨骼系统发育畸形。大鼠孕后6~15d吸入最低中毒剂量(TCLo)100ppm(7h),致胃肠道发育畸形。小鼠孕后8~15d吸入最低中毒剂量(TCLo)100ppm(7h),致颅面部(包括鼻、舌)发育畸形。大鼠多代经口给予最低中毒剂量(TDLo)41mg/kg,致泌尿生殖系统发育畸形。

6.致癌性[16]  IARC致癌性评论:G2B,可疑人类致癌物。

生态数据:

1.生态毒性[17]

LC50:43.8mg/L(96h)(虹鳟鱼,静态);100mg/L(96h)(蓝鳃太阳鱼,静态);117mg/L(48h)(青鳉);81.5mg/L(96h)(桃红对虾);28.9mg/L(48h)(水蚤)

IC50:1.85mg/L(72h)(藻类)

2.生物降解性[18]

好氧生物降解(h):672~4320

厌氧生物降解(h):168~672

3.非生物降解性[19]

光解最大光吸收波长范围(nm):220.9~296.3

水中光氧化半衰期(h):6.90×105~2.80×107

空气中光氧化半衰期(h):623~6231

一级水解半衰期(h):3500

4.其他有害作用[20]  该物质对环境有危害,在地下水中有蓄积作用。其污染行为主要体现在饮用水中,但对食品及蔬菜也能造出污染。破坏敏感水生生物的呼吸系统。在水环境中很难被生物降解。

三氯甲烷 MSDS


模块 1. 化学品
  1.1 产品标识符
    : 氯仿
    产品名称
  1.2 鉴别的其他方法
    Trichloromethane
    Methylidyne trichloride
  1.3 有关的确定了的物质或混合物的用途和建议不适合的用途
    仅用于研发。不作为药品、家庭或其它用途。

模块 2. 危险性概述

模块 14. 运输信息
  14.1 联合国危险货物编号
    欧洲陆运危规: 1888        国际海运危规: 1888        国际空运危规: 1888    
  14.2 联合国运输名称
    欧洲陆运危规: CHLOROFORM
    国际海运危规: CHLOROFORM
    国际空运危规: Chloroform
  14.3 运输危险类别
    欧洲陆运危规: 6.1        国际海运危规: 6.1        国际空运危规: 6.1    
  14.4 包裹组
    欧洲陆运危规: III        国际海运危规: III        国际空运危规: III    
  14.5 环境危险
    欧洲陆运危规: 否        国际海运危规        国际空运危规: 否    
    海洋污染物(是/否): 否
  14.6 对使用者的特别提醒
    无数据资料
  2.1 GHS-分类
    急性毒性, 经口 (类别 4)
    急性毒性, 吸入 (类别 4)
    皮肤刺激 (类别 2)
    眼睛刺激 (类别 2A)
    致癌性 (类别 2)
    生殖毒性 (类别 2)
    特异性靶器官系统毒性(一次接触) (类别 3), 中枢神经系统
    特异性靶器官系统毒性(反复接触) (类别 2), 肝, 肾
    急性水生毒性 (类别 3)
  2.2 GHS 标记要素,包括预防性的陈述
    象形图
    警示词        警告    
    危险申明
    H302 + H332        如果咽下或吸入是有害的。    
    H315        造成皮肤刺激。    
    H319        造成严重眼刺激。    
    H336        可能引起昏睡或眩晕。    
    H351        怀疑会致癌。    
    H361        怀疑对生育能力或胎儿造成伤害。    
    H373        长期或反复接触可能引起(肝, 肾)器官损害。    
    H402        对水生生物有害。    
    警告申明
    预防措施
    P201        在使用前获取特别指示。    
    P202        在读懂所有安全防范措施之前切勿操作。    
    P260        不要吸入粉尘/ 烟/ 气体/ 烟雾/ 蒸汽/ 喷雾。    
    P264        操作后彻底清洁皮肤。    
    P270        使用本产品时不要进食、饮水或吸烟。    
    P271        只能在室外或通风良好之处使用。    
    P273        避免释放到环境中。    
    P280        戴防护手套/穿防护服/戴护目镜/戴面罩.    
    事故响应
    P301 + P312        如果吞咽并觉不适: 立即呼叫解毒中心或就医。    
    P302 + P352        如接触皮肤:使用大量水冲洗。    
    P304 + P340        如果吸入:将受害人移至空气新鲜处并保持呼吸舒适的姿势休息。    
    P305 + P351 + P338        如与眼睛接触,用水缓慢温和地冲洗几分钟。如戴隐形眼镜并可方便地取    
    出,取出隐形眼镜,然后继续冲洗.
    P308 + P313        如接触到或有疑虑:求医/ 就诊。    
    P321        具体处置(见本标签上提供的急救指导)。    
    P330        漱口。    
    P332 + P313        如觉皮肤刺激:求医/就诊。    
    P337 + P313        如仍觉眼睛刺激:求医/就诊。    
    P362 + P364        脱掉玷污的衣服,清洗后方可再用。    
    安全储存
    P403 + P233        存放于通风良的地方。 保持容器密闭。    
    P405        存放处须加锁。    
    废弃处置
    P501        将内容物/ 容器处理到得到批准的废物处理厂。    
  2.3 其它危害物 - 无

模块 3. 成分/组成信息
  3.1 物 质
    : Trichloromethane
    别名
    Methylidyne trichloride
    : CHCl3
    分子式
    : 119.38 g/mol
    分子量
    组分        浓度或浓度范围    
    Chloroform
    50 - 100 %
    化学文摘登记号(CAS        67-66-3    
    No.)        200-663-8    
    EC-编号        602-006-00-4    
    索引编号
    Ethanol
    化学文摘登记号(CAS        64-17-5        1-3%    
    No.)        200-578-6    
    EC-编号        603-002-00-5    
    索引编号

模块 4. 急救措施
  4.1 必要的急救措施描述
    一般的建议
    请教医生。 向到现场的医生出示此安全技术说明书。
    吸入
    如果吸入,请将患者移到新鲜空气处。 如呼吸停止,进行人工呼吸。 请教医生。
    皮肤接触
    用肥皂和大量的水冲洗。 请教医生。
    眼睛接触
    用大量水彻底冲洗至少15分钟并请教医生。
    食入
    切勿给失去知觉者通过口喂任何东西。 用水漱口。 请教医生。
  4.2 主要症状和影响,急性和迟发效应
    据我们所知,此化学,物理和毒性性质尚未经完整的研究。
  4.3 及时的医疗处理和所需的特殊处理的说明和指示
    无数据资料

模块 5. 消防措施
  5.1 灭火介质
    灭火方法及灭火剂
    用水雾,抗乙醇泡沫,干粉或二氧化碳灭火。
  5.2 源于此物质或混合物的特别的危害
    碳氧化物, 氯化氢气体
  5.3 给消防员的建议
    如必要的话,戴自给式呼吸器去救火。
  5.4 进一步信息
    无数据资料

模块 6. 泄露应急处理
  6.1 作业人员防护措施、防护装备和应急处置程序
    使用个人防护用品。 避免吸入蒸气、烟雾或气体。 保证充分的通风。 人员疏散到安全区域。
  6.2 环境保护措施
    如能确保安全,可采取措施防止进一步的泄漏或溢出。 不要让产品进入下水道。
    一定要避免排放到周围环境中。
  6.3 泄漏化学品的收容、清除方法及所使用的处置材料
    用惰性吸附材料吸收并当作危险废物处理。 放入合适的封闭的容器中待处理。
  6.4 参考其他部分
    丢弃处理请参阅第13节。

模块 7. 操作处置与储存
  7.1 安全操作的注意事项
    避免接触皮肤和眼睛。 避免吸入蒸气和烟雾。
  7.2 安全储存的条件,包括任何不兼容性
    贮存在阴凉处。 使容器保持密闭,储存在干燥通风处。
    打开了的容器必须仔细重新封口并保持竖放位置以防止泄漏。
  7.3 特定用途
    无数据资料

模块 8. 接触控制和个体防护
  8.1 容许浓度
    最高容许浓度
    组分        化学文摘登        值 容许浓度        基准    
    记号(CAS
    No.)
    Chloroform        67-66-3        PC- 20 mg/m3        工作场所有害因素职业接触限值 -    
    TWA        化学有害因素    
    备注        可疑人类致癌物    
  8.2 暴露控制
    适当的技术控制
    根据良好的工业卫生和安全规范进行操作。 休息前和工作结束时洗手。
    个体防护设备
    眼/面保护
    面罩與安全眼鏡请使用经官方标准如NIOSH (美国) 或 EN 166(欧盟) 检测与批准的设备防护眼部。
    皮肤保护
    戴手套取 手套在使用前必须受检查。
    请使用合适的方法脱除手套(不要接触手套外部表面),避免任何皮肤部位接触此产品.
    使用后请将被污染过的手套根据相关法律法规和有效的实验室规章程序谨慎处理. 请清洗并吹干双手
    所选择的保护手套必须符合EU的89/686/EEC规定和从它衍生出来的EN 376标准。
    完全接触
    物料: 氟橡胶
    最小的层厚度 0.7 mm
    溶剂渗透时间: 480 min
    测试过的物质Vitoject® (KCL 890 / Z677698, 规格 M)
    飞溅保护
    物料: 氟橡胶
    最小的层厚度 0.7 mm
    溶剂渗透时间: 480 min
    测试过的物质Vitoject® (KCL 890 / Z677698, 规格 M)
,     测试方法 EN374
    如果以溶剂形式应用或与其它物质混合应用,或在不同于EN
    374规定的条件下应用,请与EC批准的手套的供应商联系。
    这个推荐只是建议性的,并且务必让熟悉我们客户计划使用的特定情况的工业卫生学专家评估确认才可.
    这不应该解释为在提供对任何特定使用情况方法的批准.
    身体保护
    全套防化学试剂工作服, 防护设备的类型必须根据特定工作场所中的危险物的浓度和数量来选择。
    呼吸系统防护
    如危险性评测显示需要使用空气净化的防毒面具,请使用全面罩式多功能防毒面具(US)或AXBEK
    型(EN
    14387)防毒面具筒作为工程控制的候补。如果防毒面具是保护的唯一方式,则使用全面罩式送风防
    毒面具。 呼吸器使用经过测试并通过政府标准如NIOSH(US)或CEN(EU)的呼吸器和零件。

模块 9. 理化特性
  9.1 基本的理化特性的信息
    a) 外观与性状
    形状: 液体, 透明
    颜色: 无色
    b) 气味
    无数据资料
    c) 气味阈值
    无数据资料
    d) pH值
    无数据资料
    e) 熔点/凝固点
    熔点/凝固点: -63 °C - lit.
    f) 沸点、初沸点和沸程
    60.5 - 61.5 °C - lit.
    g) 闪点
    无数据资料
    h) 蒸发速率
    无数据资料
    i) 易燃性(固体,气体)
    无数据资料
    j) 高的/低的燃烧性或爆炸性限度 无数据资料
    k) 蒸气压
    213.3 hPa 在 20.0 °C
    l) 蒸汽密度
    无数据资料
    m) 密度/相对密度
    1.492 g/mL 在 25 °C1.48 g/mL 在 25 °C
    n) 水溶性
    无数据资料
    o) n-辛醇/水分配系数
    辛醇--水的分配系数的对数值: 1.97
    p) 自燃温度
    无数据资料
    q) 分解温度
    无数据资料
    r) 粘度
    无数据资料

模块 10. 稳定性和反应活性
  10.1 反应性
    无数据资料
  10.2 稳定性
    无数据资料
    含有下列稳定剂:
    Ethanol (>=0.5 - <=1 %)
  10.3 危险反应
    无数据资料
  10.4 应避免的条件
    无数据资料
  10.5 不相容的物质
    强氧化剂, 强碱, 镁, 钠/氧化钠, 锂
  10.6 危险的分解产物
    其它分解产物 - 无数据资料

模块 11. 毒理学资料
  11.1 毒理学影响的信息
    急性毒性
    半数致死剂量 (LD50) 经口 - 大鼠 - 908 mg/kg
    备注: 行为的:运动力学变化(特异性测试) 行为的:运动失调症 肺,胸,或者呼吸系统:呼吸兴奋
    LOEC 吸入 - 大鼠 - 雄性 - 6 h - 500 ppm
    半数致死剂量 (LD50) 经皮 - 兔子 - > 20,000 mg/kg
    皮肤刺激或腐蚀
    皮肤 - 兔子 - 刺激皮肤。 - 24 h
    眼睛刺激或腐蚀
    眼睛 - 兔子 - 刺激眼睛。 - 24 h
    呼吸道或皮肤过敏
    未引起试验动物过敏。
    生殖细胞致突变性
    实验室测试表明由诱变效应
    致癌性
    致癌性 - 大鼠 - 经口
    肿瘤发生:符合RTECS标准的致癌性。 白血病
    美国国立癌症研究所(NCI)发现明显致癌 致癌证据有限。
    IARC:
    2B - 第2B组:可能对人类致癌 (Chloroform)
    生殖毒性
    有损害胎儿的嫌疑。 可疑人类的生殖毒物
    特异性靶器官系统毒性(一次接触)
    可能引起昏睡或眩晕。
    特异性靶器官系统毒性(反复接触)
    长期或重复接触可能会对器官造成伤害。 - 肝, 肾
    吸入危险
    无数据资料
    潜在的健康影响
    吸入        吸入有害。 引起呼吸道刺激。 蒸气可引起睡意和眩昏。    
    摄入        误吞对人体有害。    
    皮肤        通过皮肤吸收有害。 造成皮肤刺激。    
    眼睛        造成严重眼刺激。    
    接触后的征兆和症状
    据我们所知,此化学,物理和毒性性质尚未经完整的研究。
    附加说明
    化学物质毒性作用登记: 无数据资料

模块 12. 生态学资料
  12.1 生态毒性
    对鱼类的毒性        半数致死浓度(LC50) - 高体雅罗鱼 (金雅罗鱼) - 162 mg/l - 48 h    
    绝对致死浓度(LC100) - 高体雅罗鱼 (金雅罗鱼) - 220 mg/l - 48 h
    半数致死浓度(LC50) - 其他鱼 - 97 mg/l - 96 h
    半数致死浓度(LC50) - 斑马担尼鱼(斑马鱼) - 121 mg/l - 96 h
    无可观察效应浓度 - 青鳉鱼 - 122 mg/l - 10 d
    无可观察效应浓度 - 虹鳟 (红鳟鱼) - 24 mg/l - 96 h
    对水蚤和其他水生无脊        半数效应浓度(EC50) - 大型蚤 (水蚤) - 79.00 mg/l - 24 h    
    椎动物的毒性
    固定 半数效应浓度(EC50) - 大型蚤 (水蚤) - 51.6 mg/l - 48 h
    无可观察效应浓度 - 大型蚤 (水蚤) - 120 mg/l - 11 d
    对藻类的毒性        半数效应浓度(EC50) - 无适用资料。 - 500.00 mg/l - 24 h    
  12.2 持久性和降解性
    无数据资料
  12.3 潜在的生物累积性
    生物富集或生物积累性        蓝鳃太阳鱼 - 14 d -0.11 mg/l    
    生物富集因子 (BCF): 6
  12.4 土壤中的迁移性
    无数据资料
  12.5 PBT 和 vPvB的结果评价
    无数据资料
  12.6 其它不良影响
    对水生生物有害。

模块 13. 废弃处置
  13.1 废物处理方法
    产品
    将剩余的和不可回收的溶液交给有许可证的公司处理。
    受污染的容器和包装
    按未用产品处置。


模块 15 - 法规信息
N/A


模块16 - 其他信息
N/A

三氯甲烷 分子结构与计算化学数据

分子结构数据

1、摩尔折射率:21.18

2、摩尔体积(cm3/mol):79.5

3、等张比容(90.2K):184.6

4、表面张力(dyne/cm):28.9

5、介电常数:无可用的

6、极化率(10-24cm3):8.39

7、单一同位素质量:117.914383 Da

8、标称质量:118 Da

9、平均质量:119.3776 Da

计算化学数据

1.疏水参数计算参考值(XlogP):2.3

2.氢键供体数量:0

3.氢键受体数量:0

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:4

8.表面电荷:0

9.复杂度:8

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

三氯甲烷 上游产品

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