环戊丙酸睾酮

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品

环戊丙酸睾酮 基本信息

中文名称:
环戊丙酸睾酮 
中文别名:
环戊丙酸睾酮;
1-睾酮环戊丙酸酯;
USP限制 环戊丙酸睾酮 
英文名称:
Androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17b)-
英文别名:
testosterone cypionate;
depo-testosterone;
Jectatest;
Testex Leo;
Dep-Test;
Depotest;
DEPOVIRIN;
Andro-Cyp;
Testosterone cyclopentylpropionate;
Durandro;
Testosterone cypionate;
Depo;
Pertestis 
CAS No.:
58-20-8
分 子 式:

C27H40O3

分 子 量:
412.61
精确分子量:
412.29800
PSA:
43.37000
MDL:
MFCD00053944
EINECS:
200-368-4
InChI:
InChI=1/C27H40O3/c1-26-15-13-20(28)17-19(26)8-9-21-22-10-11-24(27(22,2)16-14-23(21)26)30-25(29)12-7-18-5-3-4-6-18/h17-18,21-24H,3-16H2,1-2H3/t21-,22-,23-,24-,26-,27-/m0/s1
危险品标志:

 

风险术语:

 

安全术语:

 

分子结构式:
SDS:
查看

环戊丙酸睾酮 制备方法及用途

制备方法

本品为人工合成的雄激素,临床上主要用于治疗无睾症或类无睾症、隐睾症、功能性子宫出血、月经过多、子宫内膜异位症、子宫肌瘤、更年期综合征、转移性乳腺癌和卵巢癌、垂体性侏儒症、老年性骨质疏松、再生障碍性贫血等。

用途简介

环戊丙酸睾酮 物化性质

外观与性状:
白色至灰白色结晶粉末
密度:
1.1 g/cm3
熔点:
98 - 104ºC
沸点:
525.9ºC at 760 mmHg
闪点:
223.9ºC
折射率:
1.546

环戊丙酸睾酮 安全信息

海关代码:
2937290018
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R45
安全说明:
S53-S22-S26-S36
RTECS号:
XA3066000
危险标志:
T

环戊丙酸睾酮 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XA3066000
CHEMICAL NAME :
Testosterone, cyclopentanepropionate
CAS REGISTRY NUMBER :
58-20-8
BEILSTEIN REFERENCE NO. :
3174363
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C27-H40-O3
MOLECULAR WEIGHT :
412.67

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,487,1982 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
4286 ug/kg
SEX/DURATION :
male 2 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
REFERENCE :
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 55,725,1952 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5357 No. of Facilities: 9 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 166 (estimated) No. of Female Employees: 105 (estimated)

环戊丙酸睾酮 MSDS


Section 1. Chemical Product and Company Identification
    Testosterone cypionate
    Common Name/
    Trade Name
    Testosterone cypionate

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at    
    least 15 minutes. Get medical attention if irritation occurs.
    Skin Contact        Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.    
    Serious Skin Contact        Not available.    
    Inhalation        If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get    
    medical attention.
    Serious Inhalation        Not available.    
    Ingestion        Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an    
    unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
    clothing such as a collar, tie, belt or waistband.
    Serious Ingestion        Not available.    

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        CLOSED CUP: Higher than 93.3°C (200°F).    
    Flammable Limits        Not available.    
    Products of Combustion        These products are carbon oxides (CO, CO2).    
    Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
    Various Substances        Non-flammable in presence of shocks.    
    Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks.
    Non-explosive in presence of shocks.
    of Various Substances
    SMALL FIRE: Use DRY chemical powder.
    Fire Fighting Media
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.    
    As with most organic solids, fire is possible at elevated temperatures. When heated to decomposition it emits
    Special Remarks on
    acrid smoke and irritating fumes.
    Fire Hazards
    Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
    Hazards        explosion hazard.    

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by    
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water    
    on the contaminated surface and allow to evacuate through the sanitary system.
    Testosterone cypionate

Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not    
    breathe dust. Wear suitable protective clothing. If you feel unwell, seek medical attention and show the label
    when possible. Keep away from incompatibles such as oxidizing agents.
    Storage        Keep container tightly closed. Keep container in a cool, well-ventilated area. Sensitive to light. Store in    
    light-resistant containers.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below    
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.    
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist    
    BEFORE handling this product.
    Exposure Limits        Not available.    

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid. (Crystalline powder)        Odor        Slight.    
    Taste        Not available.    
    Molecular Weight        412.61 g/mole    
    Color        White. Off-white.    
    pH (1% soln/water)        Not applicable.    
    Not available.
    Boiling Point
    Melting Point        98°C (208.4°F) - 104 C.    
    Not available.
    Critical Temperature
    Specific Gravity        Not available.    
    Vapor Pressure        Not applicable.    
    Vapor Density        Not available.    
    Volatility        Not available.    
    Odor Threshold        Not available.    
    Water/Oil Dist. Coeff.        Not available.    
    Ionicity (in Water)        Not available.    
    Dispersion Properties        Not available.    
    Solubility        Easily soluble in diethyl ether.    
    Insoluble in cold water, hot water.
    Freely soluble in chloroform, dioxane, alcohol.

Section 10. Stability and Reactivity Data
    Stability        The product is stable.    
    Instability Temperature        Not available.    
    Conditions of Instability        Excess heat and incompatible materials    
    Incompatibility with various Reactive with oxidizing agents.
    substances
    Testosterone cypionate
    Non-corrosive in presence of glass.
    Corrosivity
    Special Remarks on        Sensitive to light.    
    Reactivity
    Special Remarks on        Not available.    
    Corrosivity
    Will not occur.
    Polymerization

Section 11. Toxicological Information
    Routes of Entry        Absorbed through skin. Inhalation. Ingestion.    
    Toxicity to Animals        LD50: Not available.    
    LC50: Not available.
    Chronic Effects on Humans        TERATOGENIC EFFECTS: Classified POSSIBLE for human.    
    DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male
    [POSSIBLE].
    May cause damage to the following organs: blood, the reproductive system, liver.
    Other Toxic Effects on        Slightly hazardous in case of skin contact (irritant, permeator), of ingestion, of inhalation.    
    Humans
    Special Remarks on        LD50 [Mouse] - Route: Intraperitoneal; Dose: >1000 mg/ kg    
    Toxicity to Animals
    Special Remarks on        May cause adverse reproductive effects and birth defects.    
    Chronic Effects on Humans        May affect genetic material.    
    May cause cancer
    Special Remarks on other        Potential Effects of Overexposure:    
    Toxic Effects on Humans        Anabolic steroid    
    Skin: May cause skin irritation. May be absorbed through skin
    Eyes: Dust may cause eye irritation.
    Inhalation: Dust may cause respiratory tract irritaiton.
    Ingestion: May cause gastrointestinal tract irritation with upset stomach or stomach pain, nausea, vomiting,
    diarrhea. May cause water and salt retention (edema), weight gain, acne and muscular development. Other
    symptoms may include headache, unusual tiredness, dizziness, trouble sleeping, increased pubic hair growth,
    change in sex drive. Females may also experience virilizing side effects such as facial hair, deepening of the
    voice, and menstrual irregularities. Effects of chronic overexposure in women include male-pattern baldness,
    excessive body hair, prominant musculature, and hypertrophy of the clitoris, decreased breast size, oily skin,
    impaired fertility. Effects generally slowly subside on discontinuation of exposure, but with prolonged
    overexposure in women some effects may become irreversible. Overexposure in males may lead to feminizing
    side effects (breast enlargement and or soreness), and decreased spermatogenesis or impaired fertility due to
    inhibition of gonadotropin secretion and metabolic conversion of androgens to estrogens. Other symptoms of
    overexposure in males may include frequent or continuing erections, chills, pain in the scrotum or groin, difficulty
    urinating, decreased testicle size, and aggressive behavior.
    May also affect blood(clotting disorders, elevated cholesterol levels, change in red blood cell count), and liver.
    Effects on the liver may cause yellowing of the skin or eyes (jaundice).
    Chronic exposure may cause hypersensitization, masculinization in females, heart problems in males, impaired
    fertility in males and females and cancer.
    Medical Conditions Aggravated by Exposure: Hypersensitivity to material, males with breast or prostate cancer,
    hypercalcemia resulting from osteolysis, pre-exisiting liver, kidney, or heart problems, and enlarged prostate gland.

Section 12. Ecological Information
    Not available.
    Ecotoxicity
    Not available.
    BOD5 and COD
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may    
    arise.
    Toxicity of the Products        The product itself and its products of degradation are not toxic.    
    of Biodegradation
    Testosterone cypionate
    Not available.
    Special Remarks on the
    Products of Biodegradation

Section 13. Disposal Considerations
    Waste must be disposed of in accordance with federal, state and local environmental
    Waste Disposal
    control regulations.

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).    
    Not applicable.
    Identification
    Special Provisions for        Not applicable.    
    Transport
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    Federal and State        California prop. 65: This product contains the following ingredients for which the State of California has found to    
    cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
    Regulations
    Testosterone cypionate
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause reproductive harm (female) which would require a warning under the statute: Testosterone cypionate
    (Listed as Anabolic Steroid)
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause reproductive harm (male) which would require a warning under the statute: Testosterone cypionate (Listed
    as Anabolic Steroid)
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause birth defects which would require a warning under the statute: Testosterone cypionate
    California prop. 65: This product contains the following ingredients for which the State of California has found to
    cause cancer which would require a warning under the statute: Testosterone cypionate (List3ed as Testosterone
    and its Esters)
    California        California prop. 65: This product contains the following ingredients for which the State of California has found    
    Proposition 65        to cause cancer which would require a warning under the statute: Testosterone cypionate    
    Warnings
    California prop. 65: This product contains the following ingredients for which the State of California has found
    to cause birth defects which would require a warning under the statute: Testosterone cypionate
    Other Regulations        EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.    
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    DSCL (EEC)        R45- May cause cancer.        S36/37- Wear suitable protective clothing and    
    R63- Possible risk of harm to the        gloves.    
    unborn child.        S46- If swallowed, seek medical advice    
    immediately and show this container or label.
    S53- Avoid exposure - obtain special
    instructions before use.
    Health Hazard
    HMIS (U.S.A.)        1 National Fire Protection    
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    1 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    Testosterone cypionate
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.
    Testosterone cypionate
    All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is
    combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper
    methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products,


SECTION 16 - ADDITIONAL INFORMATION
N/A

环戊丙酸睾酮 分子结构与计算化学数据

分子结构数据

1、   摩尔折射率:118.41

2、   摩尔体积(cm3/mol):373.8

3、   等张比容(90.2K)961.2

4、   表面张力(dyne/cm)43.7

5、   极化率(10-24cm3)46.94

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