Section I.Chemical Product and Company Identification
Chemical Name Emetine Hydrochloride
Portland OR
Synonym Amebicide
Chemical Formula C29H40N2O4•2HCl•xH2O
CAS Number 316-42-7
Section II. Composition and Information on Ingredients
Chemical Name CAS Number Percent (%) TLV/PEL Toxicology Data
Emetine Hydrochloride 316-42-7 Min. 98.0 (T) Not available. Rat LD50 (intraperitoneal) 17mg/kg
Rat LD50 (oral) 120mg/kg
Rat LD50 (subcutaneous) 95mg/kg
Section III. Hazards Identification
Acute Health Effects Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness
or death. Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system.
Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching,
scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper
protective equipment when handling this compound.
CARCINOGENIC EFFECTS : Not available.
Chronic Health Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
many human organs.
Section IV. First Aid Measures
Eye Contact Check for and remove any contact lenses. IMMEDIATELY flush eyes with runing water for at least 15 minutes. keeping
eyelids open. COLD water may be used. DO NOT use an eye oitment. Flush eyes with running water for a minimum of
15 minutes, occasionally lifting the upper eyelids. Seek medical attention. Treat symptomatically and supportively.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thorough wash the contaminated skin with
running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin. COLD water
may be used. Cover the irritated skin with an emollient. Seek medical attention. Treat symptomatically and supportively.
Wash any contaminated clothing before reusing.
Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If
breathing is difficult, administer oxygen. If the victim is not breathing, perform artificial respiration. WARNING: It may be
dangerous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious
or corrosive. Seek immediate medical attention and, if possible, show the chemical label. Treat symptomatically and
supportively.
Ingestion INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Loosen tight clothing such as a collar, tie, belt, or waistband. If the victim is not breathing, administer artificial respiration.
Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic material
was ingested; the absence of such signs, however, is not conclusive. Seek immediate medical attention and, if possible,
show the chemical label. Treat symptomatically and supportively.
Section V. Fire and Explosion Data
Not available.
Flammability May be combustible at high temperature. Auto-Ignition
Flammable Limits
Flash Points Not available.
Not available.
Combustion Products These products are toxic carbon oxides (CO, CO 2), nitrogen oxides (NO, NO2), halogenated compounds.
WARNING: Highly toxic HCl gas is produced during combustion.
Fire Hazards
No specific information is available regarding the flammability of this compound in the presence of various materials.
Continued on Next Page
Emetine Hydrochloride
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
No additional information is available regarding the risks of explosion.
Fire Fighting Media
SMALL FIRE: Use DRY chemicals, CO 2, water spray or foam.
and Instructions LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
Section VI. Accidental Release Measures
Spill Cleanup
Highly toxic material. Irritating material.
In case of a spill and/or a leak, always shut off any sources of ignition, ventilate the area, and exercise caution. Use a
Instructions
shovel to put the material into a convenient waste disposal container. Consult federal, state, and/or local authorities for
assistance on disposal.
Section VII. Handling and Storage
Handling and Storage HIGHLY TOXIC. IRRITANT. Handle with caution and minimize exposure. Keep away from heat and sources of ignition.
Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool place. Avoid excessive
Information
heat and light. DO NOT ingest. DO NOT breathe dust. Wear suitable protective clothing. If ingested, seek medical
advice immediately and show the container or the label. Treat symptomatically and supportively.
Always store away from incompatible compounds such as oxidizing agents.
Section VIII. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator must be used to avoid
inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling
this product.
Exposure Limits Not available.
Section IX. Physical and Chemical Properties
Solubility
Physical state @ 20°C White to pale-yellow powder. 1g dissolves in about 7mL water.
Soluble in alcohol.
Not available.
Specific Gravity
Molecular Weight 553.56 (Anh) Partition Coefficient Not available.
Boiling Point Not available. Vapor Pressure Not available.
Melting Point 235°C (decomp.) Vapor Density Not available.
Not available. Volatility Not available.
Refractive Index
Critical Temperature Odor Not available.
Not available.
Not available. Not available.
Viscosity Taste
Section X. Stability and Reactivity Data
Stability
This material is stable if stored under proper conditions. (See Section VII for instructions)
Conditions of Instability
Avoid excessive heat and light.
Incompatibilities
Reactive with strong oxidizing agents.
Section XI. Toxicological Information
RTECS Number JY5250000
Routes of Exposure Eye contact. Ingestion. Inhalation. Skin contact.
Rat LD50 (intraperitoneal) 17mg/kg
Toxicity Data
Rat LD50 (oral) 120mg/kg
Rat LD50 (subcutaneous) 95mg/kg
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated exposure to an highly toxic material may produce general deterioration of health by an accumulation in one or
many human organs.
Continued on Next Page
Emetine Hydrochloride
Acute Toxic Effects Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness
or death. Irritating to eyes and skin on contact. Inhalation causes irritation of the lungs and respiratory system.
Inflammation of the eye is characterized by redness, watering, and itching. Skin inflammation is characterized by itching,
scaling, reddening, or, occasionally, blistering. Follow safe industrial hygiene practices and always wear proper
protective equipment when handling this compound.
Section XII. Ecological Information
Ecotoxicity Not available.
Not available.
Environmental Fate
Section XIII. Disposal Considerations
Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with
Waste Disposal
a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state, and local regulations when disposing of the substance.
Section XIV. Transport Information
DOT Classification DOT CLASS 6.1: Toxic material.
PIN Number
Proper Shipping Name
Alkaloids solid, n.o.s.
Packing Group (PG) II
DOT Pictograms
Section XV. Other Regulatory Information and Pictograms
TSCA Chemical Inventory This compound is ON the EPA Toxic Substances Control Act (TSCA) inventory list.
(EPA)
WHMIS Classification
Not available.
(Canada)
EINECS Number (EEC) 206-259-8
EEC Risk Statements R23/24/25- Toxic by inhalation, in contact with skin and if swallowed.
R36/37/38- Irritating to eyes, respiratory system and skin.
Japanese Regulatory Data
SECTION 16 - ADDITIONAL INFORMATION
N/A
