L-苯丙氨酸

外观与性状：

白色结晶粉末

密度：

1.201 g/cm3

熔点：

270-275ºC (dec.)(lit.)

沸点：

307.5ºC at 760 mmHg

闪点：

139.8ºC

存储条件/存储方法：

1.本品应密封于阴凉干燥处避光保存。

2.以纸桶装，25kg／桶。远离强氧化剂。

稳定性相关：

   1. 溶于水，微溶于乙醇、乙醚。味略苦，干燥状态在空气中稳定，具有左旋光活性，是人体必需的８种氨基酸之一。

　2.吸入、食入及接触有害。如误服本品，误服者有意识未发生痉挛，可使其饮1～2杯水以稀释，然后立即送医院。应穿戴防护用具。

3. 存在于烟叶、烟气中。

其它信息：

1.       性状：无色至白色片状晶体或白色结晶性粉末。略有特殊气味和苦味

2.       密度（g/mL,25/4℃）：1.201

3.       相对蒸汽密度（g/mL,空气=1）：不确定

4.       熔点（ºC）：283(dec.)(lit.)

5.       沸点（ºC,常压）：不确定

6.       沸点（ºC, 5.2kPa）：不确定

7.       折射率：-34 ° (C=2, H2O)

8.       闪点（ºC）：不确定

9.       比旋光度（º）：-34.1 º (c=2, water, dry basis)

10.    自燃点或引燃温度（ºC）：不确定

11.    蒸气压（kPa,25ºC）：不确定

12.    饱和蒸气压（kPa,60ºC）：不确定

13.    燃烧热（KJ/mol）：不确定

14.    临界温度（ºC）：不确定

15.    临界压力（KPa）：不确定

16.    油水（辛醇/水）分配系数的对数值：不确定

17.    爆炸上限（%,V/V）：不确定

18.    爆炸下限（%,V/V）：不确定

19.    溶解性：溶于水(3g/100ml，25℃)。微溶于乙醇、稀无机酸和碱性溶液。

海关代码：

29224995

WGK_Germany：

3
德国有关水污染物质的分类清单

危险类别码：

R36/37/38

安全说明：

22-24/25-37/39-45-36/37/39-27-26

危险标志：

C: Corrosive;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AY7535000

CHEMICAL NAME :

Alanine, phenyl-, L-

CAS REGISTRY NUMBER :

63-91-2

LAST UPDATED :

199706

DATA ITEMS CITED :

18

MOLECULAR FORMULA :

C9-H11-N-O2

MOLECULAR WEIGHT :

165.21

WISWESSER LINE NOTATION :

QVYZ1R -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5287 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>1322 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

276 gm/kg/13W-C

TOXIC EFFECTS :

Behavioral - alteration of operant conditioning Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

220 gm/kg

SEX/DURATION :

male 2 week(s) pre-mating female 2 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

160 gm/kg

SEX/DURATION :

male 2 week(s) pre-mating female 2 week(s) pre-mating - 8 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

192 gm/kg

SEX/DURATION :

male 2 week(s) pre-mating female 2 week(s) pre-mating - 15 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - physical

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

21750 mg/kg

SEX/DURATION :

female 15-19 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

30 gm/kg

SEX/DURATION :

female 10-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

7930 mg/kg

SEX/DURATION :

female 8-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

1980 mg/kg

SEX/DURATION :

female 9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

2640 mg/kg

SEX/DURATION :

female 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

6048 mg/kg

SEX/DURATION :

female 8-11 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system Reproductive - Effects on Newborn - biochemical and metabolic

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

30 mg/kg

SEX/DURATION :

female 3 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

33600 mg/kg

SEX/DURATION :

female 1-24 week(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - behavioral

MUTATION DATA

TYPE OF TEST :

Sister chromatid exchange

TEST SYSTEM :

Human Lymphocyte

DOSE/DURATION :

10 mg/L

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 280,279,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5534 No. of Facilities: 792 (estimated) No. of Industries: 4 No. of Occupations: 14 No. of Employees: 19901 (estimated) No. of Female Employees: 14903 (estimated)

分子结构数据

 1、   摩尔折射率：45.49

2、   摩尔体积（cm³/mol）：137.4

3、   等张比容（90.2K）：371.8

4、   表面张力（dyne/cm）：53.5

5、   极化率（10^-24cm³）：18.03

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:2

3.氢键受体数量:3

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积63.3

7.重原子数量:12

8.表面电荷:0

9.复杂度:153

10.同位素原子数量:0

11.确定原子立构中心数量:1

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  苯丙氨酸红外图谱(IR1)
• 
  苯丙氨酸红外图谱(IR2)
• 
  苯丙氨酸质谱(MS)
• 
  苯丙氨酸核磁图(¹³CNMR)
• 
  苯丙氨酸Raman光谱
• 
  苯丙氨酸核磁图(¹HNMR)