N,O-双(三甲基硅烷基)三氟乙酰胺

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学
  • 上游产品
  • 下游产品
  • 表征图谱

N,O-双(三甲基硅烷基)三氟乙酰胺 基本信息

中文名称:
N,O-双(三甲基硅烷基)三氟乙酰胺 
中文别名:
N,O-双(三甲基硅烷基)三氟乙酰胺;
BSTFA,衍生化级;
N,O-双(三甲基硅基)三氟乙酰胺;
双(三甲基硅基)三氟乙酰胺 
英文名称:
N,O-bis(trimethylsilyl)trifluoroacetamide
英文别名:
N,O-bis(trimethylsilyl)trifluoroacetamide;
N,O-bis-TMS-trifluoroacetamide;
8 Reaction vial,capacity;
N,O-BSTFA;
bstfa + tmcs;
BSTFA;
N,O-Bis(trimethylsilyl)trifluoroacetamide Kit BSTFA 1 mL ×Bis(trimethylsilyl);
REGISIL RC-2;
REGISIL RC-3;
REGISIL RC-1;
Bis(trimethylsilyl)trifluoroacetamide;
bstfa kit;
REGISIL(R) RC-1 
CAS No.:
25561-30-2
分 子 式:
C8H18F3NOSi2
分 子 量:
257.40100
精确分子量:
257.08800
PSA:
21.59000
MDL:
MFCD00008269
EINECS:
247-103-9
BRN:
3607620
InChI:
InChI=1/C8H18F3NOSi2/c1-14(2,3)8(9,15(4,5)6)7(13)12(10)11/h1-6H3
风险术语:
11-34-10-35-14
分子结构式:
SDS:
查看

N,O-双(三甲基硅烷基)三氟乙酰胺 制备方法及用途

制备方法

医药中间体。

用途简介

用途

医药中间体,中性硅烷化保护剂,主要用于合成头孢类抗生素

N,O-双(三甲基硅烷基)三氟乙酰胺 物化性质

外观与性状:
透明至淡黄色透明液体
密度:
0.97 g/mL(lit.)
熔点:
-10°C
沸点:
45-50 °C14 mm Hg(lit.)
闪点:
75 °C
水溶解性:
hydrolyses
折射率:
n20/D 1.384(lit.)
蒸汽压:
0.193mmHg at 25°C
存储条件/存储方法:

2-8℃

稳定性相关:

如果遵照规格使用和储存则不会分解

避免接触氧化物,酸
其它信息:

 

1.         性状:无色液体。

2.         密度(g/mL,25/4℃): 0.969

3.         相对蒸汽密度(g/mL,空气=1):未确定

4.         熔点(ºC): 未确定

5.         沸点(ºC,常压): 145~147

6.         沸点(ºC,5.2kPa):未确定

7.         折射率: 1.3840

8.         闪点(ºC): 23

9.         比旋光度(º):未确定

10.     自燃点或引燃温度(ºC):未确定

11.     蒸气压(kPa,25ºC):未确定

12.     饱和蒸气压(kPa,60ºC):未确定

13.     燃烧热(KJ/mol):未确定

14.     临界温度(ºC):未确定

15.     临界压力(KPa):未确定

16.     油水(辛醇/水)分配系数的对数值:未确定

17.     爆炸上限(%,V/V):未确定

18.     爆炸下限(%,V/V):未确定

19.     溶解性:未确定。

N,O-双(三甲基硅烷基)三氟乙酰胺 安全信息

包装等级:
III
风险类别:
3
海关代码:
29310095
WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
R10;R34
安全说明:
S26-S36/37/39-S45-S16
危险标志:
C:Corrosive

N,O-双(三甲基硅烷基)三氟乙酰胺 毒理性

毒理学数据:

主要的刺激性影响:

在皮肤上面:

在皮肤和粘膜上造成腐蚀性影响

刺激皮肤和粘膜

在眼睛上面:

强烈的腐蚀性影响

刺激的影响

致敏作用:没有已知的敏化作用。

生态数据:

对水是稍微危害的,若无政府许可,勿将材料排入周围环境

N,O-双(三甲基硅烷基)三氟乙酰胺 MSDS

Name: Bis(trimethylsilyl)trifluoroacetamide packaged in 1 ml ampules Material Safety Data Sheet
Synonym: BSTF
CAS: 25561-30-2
Section 1 - Chemical Product   MSDS Name:Bis(trimethylsilyl)trifluoroacetamide packaged in 1 ml ampules Material Safety Data Sheet
Synonym:BSTF

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
25561-30-2 Bis(trimethylsilyl)trifluoroacetamide, 99+% 247-103-9
Hazard Symbols: XI
Risk Phrases: 10 36/37/38

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
Flammable. Irritating to eyes, respiratory system and skin.Moisture sensitive.The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
No information regarding eye irritation and other potential effects was found.
Skin:
No information regarding skin irritation and other potential effects was found.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
The toxicological properties of this substance have not been fully investigated.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Notes to Physician:

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Flammable liquid and vapor.
Extinguishing Media:
Use agent most appropriate to extinguish fire.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition.
Use a spark-proof tool.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Use only in a well-ventilated area.
Ground and bond containers when transferring material. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Storage:
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low.
Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Liquid
Appearance: clear, colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 45.0 - 50.0 deg C @
Freezing/Melting Point: -10 deg C
Autoignition Temperature: > 300 deg C (> 572.00 deg F)
Flash Point: 43 deg C ( 109.40 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: hydrolysis
Specific Gravity/Density: .9690g/cm3
Molecular Formula: CF3C=NSi(CH3)3OSi(CH3)3
Molecular Weight: 257.39

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, excess heat, electrical sparks.
Incompatibilities with Other Materials:
Strong oxidizing agents, strong acids.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride, nitrogen, silicon oxide.
Hazardous Polymerization: Has not been reported.

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 25561-30-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
Bis(trimethylsilyl)trifluoroacetamide, packaged in 1 ml ampules - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
 

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Shipping Name: FLAMMABLE LIQUID, N.O.S.*
Hazard Class: 3
UN Number: 1993
Packing Group: III
IMO
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Hazard Class: 3.3
UN Number: 1993
Packing Group: III
RID/ADR
Shipping Name: FLAMMABLE LIQUID, N.O.S.
Dangerous Goods Code: 3(31C)
UN Number: 1993

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 10 Flammable.
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 25561-30-2: No information available.
United Kingdom Occupational Exposure Limits
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 25561-30-2 is not listed on Canada's Ingredient Disclosure List.
Exposure Limits
US FEDERAL
TSCA
CAS# 25561-30-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

N,O-双(三甲基硅烷基)三氟乙酰胺 分子结构与计算化学数据

分子结构数据

 

1、   摩尔折射率:60.75

2、   摩尔体积(cm3/mol):252.8

3、   等张比容(90.2K):523.1

4、   表面张力(dyne/cm):18.3

5、   极化率(10-24cm3):24.08

 

计算化学数据

1、   氢键供体数量:0

2、   氢键受体数量:5

3、   可旋转化学键数量:3

4、   拓扑分子极性表面积(TPSA):21.6

5、   重原子数:15

6、   表面电荷:0

7、   复杂度:250

8、   同位素原子数量:0

9、   确定原子立构中心数量:0

10、           不确定原子立构中心数量:0

11、           确定化学键立构中心数量:0

12、           不确定化学键立构中心数量:1

13、           共价键单元数量:1

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