三氯化磷

外观与性状：

透明液体

密度：

1.574 g/mL at 25 °C

熔点：

-112 °C

沸点：

74-78 °C(lit.)

闪点：

76°C

水溶解性：

reacts

折射率：

n20/D 1.5148(lit.)

蒸汽密度：

4.75 (vs air)

存储条件/存储方法：

库房通风低温干燥,与碱类、氧化剂、有机物、易燃物分开存放

稳定性相关：

1.露于潮湿空气中能水解成亚磷酸和氯化氢，发生白烟而变质。遇乙醇和水起分解反应。与氧作用生成三氯氧磷，与氯作用生成五氯化磷，与有机物接触会着火。易燃。易刺激黏膜，有腐蚀性。有毒！失火时，可用干砂土、干粉灭火器扑救，不可用水。

2.具有强烈的吸湿性，对空气和湿气敏感，遇水会发生剧烈反应并产生酸。在密闭的容器中遇水时会发生爆炸，应在通风橱中进行操作。该试剂具有很强的毒性，吸入体内对肺部和呼吸道造成严重的伤害、甚至可能致死。

3.稳定性^[23]  稳定

4.禁配物^[24]  强碱、强氧化剂、水、酸类、醇类、钾、钠、金属氧化物

5.避免接触的条件^[25]  潮湿空气

6.聚合危害^[26]  不聚合

其它信息：

1.性状：无色澄清液体，在潮湿空气中发烟。^[11]

2.熔点（℃）：-111.8^[12]

3.沸点（℃）：76^[13]

4.相对密度（水=1）：1.57（21℃）^[14]

5.相对蒸气密度（空气=1）：4.75^[15]

6.饱和蒸气压（kPa）：13.33（21℃）^[16]

7.临界压力（MPa）：5.67^[17]

8.辛醇/水分配系数：2.01^[18]

9.溶解性：可混溶于二硫化碳、乙醚、四氯化碳、苯。^[19]

包装等级：

I

风险类别：

6.1

海关代码：

2812104300

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R14;R26/28;R35;R40;R48/20

安全说明：

S26-S36/37/39-S45-S7/8-S43-S28

RTECS号：

TH3675000

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：

C:Corrosive;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TH3675000

CHEMICAL NAME :

Phosphorus chloride

CAS REGISTRY NUMBER :

7719-12-2

LAST UPDATED :

199712

DATA ITEMS CITED :

38

MOLECULAR FORMULA :

Cl3-P

MOLECULAR WEIGHT :

137.32

WISWESSER LINE NOTATION :

P G3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

18 mg/kg

TOXIC EFFECTS :

Behavioral - food intake (animal) Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - peritonitis

REFERENCE :

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,71,1990

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

104 ppm/4H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1260 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Liver - change in gall bladder structure or function Blood - other changes

REFERENCE :

ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,71,1990

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

50 ppm/4H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - irritability Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 25,470,1964

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

350 mg/kg

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 *** REVIEWS *** ACGIH TLV-STEL 2.8 mg/m3 (0.5 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 1.1 mg/m3 (0.2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 ppm (3 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,211,1971 OSHA PEL (Gen Indu):8H TWA 0.5 ppm (3 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 ppm (3 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 ppm (3 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 ppm (3 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 0.2 ppm (1.5 mg/m3);STEL 0.5 ppm (3 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.2 ppm (1.1 mg/m3);STEL 0.5 ppm (2.8 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.2 ppm (1.2 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.5 ppm (3 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-HUNGARY:TWA 1 mg/m3;STEL 2 mg/m3 JAN 1993 OEL-JAPAN:TWA 0.2 ppm (1.1 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 ppm (1.5 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-POLAND:TWA 3 mg/m3 JAN 1993 OEL-RUSSIA:TWA 0.2 ppm;STEL 0.2 mg/m3;Skin JAN 1993 OEL-SWITZERLAND:TWA 0.25 ppm (1.5 mg/m3);STEL 0.5 ppm (3 mg/m3) JAN 1993 OEL-THAILAND:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.5 ppm (3 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.2 ppm (1.5 mg/m3);STEL 0.5 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHOSPHORUS TRICHLORIDE-air:10H TWA 0.2 ppm;STEL 0.5 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 59166 No. of Facilities: 149 (estimated) No. of Industries: 4 No. of Occupations: 12 No. of Employees: 2520 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 59166 No. of Facilities: 96 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 2963 (estimated) No. of Female Employees: 329 (estimated)

毒理学数据：

1.急性毒性^[20] 

LD50：550mg/kg（大鼠经口）

LC50：582.4mg/m³（大鼠吸入，4h）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[21] 大鼠吸入浓度33.5mg/m³，60d，出现体重增长缓慢和皮肤溃疡等。

生态数据：

1.生态毒性  暂无资料

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

4.其他有害作用^[22] 该物质对环境有危害，应特别注意对水体的污染。

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm³/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10^-24cm³）：无可用的

7、单一同位素质量：135.880319Da

8、标称质量：136Da

9、平均质量：137.3328Da

计算化学数据

1、疏水参数计算参考值（XlogP）：2.3

2、氢键供体数量：0

3、氢键受体数量：0

4、可旋转化学键数量：0

5、互变异构体数量：无

6、拓扑分子极性表面积（TPSA）：0

7、重原子数量：4

8、表面电荷：0

9、复杂度：8

10、同位素原子数量：0

11、确定原子立构中心数量：0

12、不确定原子立构中心数量：0

13、确定化学键立构中心数量：0

14、不确定化学键立构中心数量：0

15、共价键单元数量：1

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  三氯化磷质谱(MS)