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哈洒唑仑
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 上游产品
- 下游产品
哈洒唑仑 基本信息
- 中文名称：
- 哈洒唑仑
- 中文别名：
- 卤恶唑仑;
10-溴-11B-(2-氟苯基)-2,3,5,7-四氢-[1,3]恶唑并[3,2-D][1,4]苯并二氮杂卓-6-酮;
哈洒唑仑
- 英文名称：
- Haloxazolam
- 英文别名：
- Haloxazolam;
10-bromo-11b-(2-fluorophenyl)-2,3,5,7-tetrahydro-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
- CAS No.：
- 59128-97-1
- 分 子 式：
- C17H14BrFN2O2
- 分 子 量：
- 377.21
- 精确分子量：
- 376.02200
- PSA：
- 41.57000
- InChI：
- InChI=1/C17H14BrFN2O2/c18-11-5-6-15-13(9-11)17(12-3-1-2-4-14(12)19)21(7-8-23-17)10-16(22)20-15/h1-6,9H,7-8,10H2,(H,20,22)
- 分子结构式：
-
- SDS：
- 查看
哈洒唑仑 物化性质
- 密度：
- 1.64g/cm3
- 沸点：
- 506.8ºC at 760 mmHg
- 闪点：
- 260.3ºC
- 折射率：
- 1.691
哈洒唑仑 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RQ5831500
- CHEMICAL NAME :
- Oxazolo(3,2-d)(1,4)benzodiazepin-6(5H)-one,
2,3,7,11b-tetrahydro-10-bromo-11b-(2-fluoro phenyl)-
- CAS REGISTRY NUMBER :
- 59128-97-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C17-H14-Br-F-N2-O2
- MOLECULAR WEIGHT :
- 377.24
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2858 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 27,64,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,1501,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,1501,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1413 mg/kg
- TOXIC EFFECTS :
- Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 27,64,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,1501,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 22,1501,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3600 mg/kg
- SEX/DURATION :
- female 1-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- SKKNAJ Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research
Laboratories. (Sankyo K.K. Sogo Kenkyusho, 1-2-58 Hiro-machi, Shinagawa-ku,
Tokyo 140, Japan) No.15- 1963- Volume(issue)/page/year: 27,64,1975
