磷酯酰乙醇胺

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • MSDS
  • 结构与计算化学

磷酯酰乙醇胺 基本信息

中文名称:
磷酯酰乙醇胺 
中文别名:
1,2-二酰基-sn-甘油-3-磷酸乙醇胺 L-α-磷脂酰乙醇胺;
磷酯酰乙醇胺;
脑磷脂;
L-α-磷酯酰乙醇胺 
英文名称:
Phosphatidylethanolamine from sheep brain
英文别名:
[2-acetyloxy-3-[2-aminoethoxy(hydroxy)phosphoryl]oxypropyl] acetate;
2-aminoethoxy(2,3-bis(acetyloxy)propoxy)phosphinic acid 
CAS No.:
90989-93-8
分 子 式:
C9H18NO8P
分 子 量:
299.21500
精确分子量:
299.07700
PSA:
144.19000
MDL:
MFCD02265857
EINECS:
292-752-3
风险术语:
R22R45R46R23/24/25R36/37/38R48/20/22
安全术语:
S23S26S45S53S36/S37/S39
分子结构式:
SDS:
查看

磷酯酰乙醇胺 制备方法及用途

制备方法

方法一、醇-醚分离 提取胆固醇和卵磷脂 取新鲜或冷冻大脑或脊髓,去膜及血丝等杂质,绞碎,用1.2倍量丙酮浸渍4.5h,不断搅拌,过滤,反复浸渍5次,滤液制胆固醇。滤饼真空干燥,加入2-3倍量乙醇,于35-40℃提取12h,过滤,再提取1次,滤液制卵磷脂,滤饼真空干燥。 沉淀物的制备 滤饼中加入乙醚提取12h,过滤,再提取1次,合并两次滤液,滤液浓缩,得浓缩液。将浓缩液0℃放置12h,离心,取上清液加入60℃乙醇,边加边搅拌,过滤,收集沉淀物。 滤饼[乙醚]→ 滤液[浓缩,离心]→上清液[乙醇]→沉淀物 脑磷脂成品的制备 在沉淀中加入乙醚,0℃静置,过滤,得滤液。滤液中加入乙醇,沉淀,过滤,收集沉淀物,真空干燥,即得脑磷脂成品。 沉淀物[乙醚]→[0℃]滤液[乙醇]→脑磷脂成品 方法二、氯化钙沉淀 粗制脑磷脂的制备 取大脑干加3倍量乙醚,加热至沸,过滤,滤渣再提取一次,合并两次滤液,将滤液浓缩至1/3体积,得浓缩液。 大脑干[乙醚]→滤液[浓缩]→浓缩液 粗制脑磷脂的制备 将浓缩液中加3倍量80%以上的乙醇,水浴加热溶解,冷至过夜,分层,过滤,滤液制卵磷脂和胆固醇,沉淀加少量水,加5g/L。氯化钙,于100℃收集沉淀,将沉淀干燥,得粗制脑磷脂。 脑磷脂成品的制备 粗制脑磷脂加3倍量乙醇,冷室沉淀4h,过滤,如此反复5次,得沉淀,沉淀加乙醚溶解,过滤,得滤液,滤液加等量乙醇或丙酮,沉淀,过滤,将沉淀物真空干燥,即得脑磷脂成品。 粗制脑磷脂[乙醇]→沉淀[乙醚]→滤液[乙醇或丙酮]→脑磷脂成品粗制脑磷脂[乙醇]→沉淀[乙醚]→滤液[乙醇或丙酮]→脑磷脂成品。

合成制备方法

方法一、醇-醚分离

提取胆固醇和卵磷脂 取新鲜或冷冻大脑或脊髓,去膜及血丝等杂质,绞碎,用1.2倍量丙酮浸渍4.5h,不断搅拌,过滤,反复浸渍5次,滤液制胆固醇。滤饼真空干燥,加入2-3倍量乙醇,于35-40℃提取12h,过滤,再提取1次,滤液制卵磷脂,滤饼真空干燥。

 

沉淀物的制备 滤饼中加入乙醚提取12h,过滤,再提取1次,合并两次滤液,滤液浓缩,得浓缩液。将浓缩液0℃放置12h,离心,取上清液加入60℃乙醇,边加边搅拌,过滤,收集沉淀物。

滤饼[乙醚]→[12h]滤液[浓缩,离心]→上清液[乙醇]→沉淀物

脑磷脂成品的制备 在沉淀中加入乙醚,0℃静置,过滤,得滤液。滤液中加入乙醇,沉淀,过滤,收集沉淀物,真空干燥,即得脑磷脂成品。

沉淀物[乙醚]→[0℃]滤液[乙醇]→脑磷脂成品

方法二、氯化钙沉淀

粗制脑磷脂的制备 取大脑干加3倍量乙醚,加热至沸,过滤,滤渣再提取一次,合并两次滤液,将滤液浓缩至1/3体积,得浓缩液。

大脑干[乙醚]→滤液[浓缩]→浓缩液

粗制脑磷脂的制备 将浓缩液中加3倍量80%以上的乙醇,水浴加热溶解,冷至过夜,分层,过滤,滤液制卵磷脂和胆固醇,沉淀加少量水,加5g/L。氯化钙,于100℃收集沉淀,将沉淀干燥,得粗制脑磷脂。

 脑磷脂成品的制备 粗制脑磷脂加3倍量乙醇,冷室沉淀4h,过滤,如此反复5次,得沉淀,沉淀加乙醚溶解,过滤,得滤液,滤液加等量乙醇或丙酮,沉淀,过滤,将沉淀物真空干燥,即得脑磷脂成品。

粗制脑磷脂[乙醇]→沉淀[乙醚]→滤液[乙醇或丙酮]→脑磷脂成品粗制脑磷脂[乙醇]→沉淀[乙醚]→滤液[乙醇或丙酮]→脑磷脂成品。

用途简介

在生物界所存在的磷脂中,磷酯酰乙醇胺的含量仅次于卵磷脂,在大肠菌中,其约占总磷脂的80%。组成脂肪酸每因生物不同而异,在微生物和卵黄中的,构成的饱和脂肪酸比动物组织中多。在生物界还存在着含有单甲基乙醇胺、二甲基乙醇胺的衍生物。这些都通过S-腺苷甲硫氨酸使磷脂酰乙醇胺甲基化而形成的,E.P.Ke-nnedy等(1956,1964)证明在微生物中,磷酯酰乙醇胺是通过磷酯酰丝氨酸的脱羧作用形成的。在动物中,它是通过CDP乙醇胺和1,2-甘油二酯的反应生成的。通过磷酯酶A的作用生成溶血磷酯酰乙醇胺。据很道,在老鼠肝脏中,它与卵磷酯一起在微粒体,线粒体间进行转移。

用途

1.防止肝硬化和肝脂肪性病变,并适用于神经衰弱,并用于局部止血。羊脑磷脂可作肝功能诊断试剂。 可用作抗氧剂,用于食品、保健食品和药品中.

 

磷酯酰乙醇胺 物化性质

存储条件/存储方法:

-20°C冷藏、密闭、干燥处

稳定性相关:

按规定使用和贮存的不会分解,避氧化物、潮湿、空气

其它信息:

1.      性状:棕色冻干粉

2.      密度(g/mL25 ºC):未确定

3.      相对蒸汽密度(g/mL,空气=1):未确定

4.      熔点(ºC):未确定

5.      沸点(ºC,常压):未确定

6.      沸点(ºC0.1mmHg):未确定

7.      折射率:未确定

8.      闪点(ºC0.1mmHg):未确定

9.      比旋光度(º):未确定

10.   自燃点或引燃温度(ºC):未确定

11.   蒸气压(Pa,):未确定

12.   饱和蒸气压(kPa,60ºC):未确定

13.   燃烧热(KJ/mol):未确定

14.   临界温度(ºC):未确定

15.   临界压力(KPa):未确定

16.   油水(正辛醇/水)分配系数的对数值:未确定

17.   爆炸上限(%,V/V):未确定

18.   爆炸下限(%,V/V):未确定

19.   溶解性:溶于石油醚、氯仿、乙醚、和甲醇,微溶于苯和四氯化碳,不溶于水

磷酯酰乙醇胺 安全信息

危险类别码:
R45
安全说明:
S53
安全标志:
S23:不要吸入蒸汽。
S26:万一接触眼睛,立即使用大量清水冲洗并送医诊治。
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
S53:避免暴露——使用前先阅读专门的说明。
:
危险标志:
T: Toxic;

磷酯酰乙醇胺 MSDS


Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
  Product identifiers
    Product name        : 3-sn-Phosphatidylethanolamine, from sheep brain    
    CAS-No.        : 90989-93-8    
  Relevant identified uses of the substance or mixture and uses advised against
    Identified uses        : Laboratory chemicals, Manufacture of substances    
  
  

Section 2. HAZARDS IDENTIFICATION
  Classification of the substance or mixture
    Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008
    This substance is not classified as dangerous according to Directive 67/548/EEC.
  Label elements
    This substance is not classified as dangerous according to Directive 67/548/EEC.
  Other hazards - none

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
  Substances
    : L-α-Phosphatidylethanolaminefrom sheep brain
    Synonyms
    1,2-Diacyl-sn-glycero-3-phosphoethanolamine
    L-α-Cephalin

Section 4. FIRST AID MEASURES
  Description of first aid measures
  If inhaled
    If breathed in, move person into fresh air. If not breathing, give artificial respiration.
  In case of skin contact
    Wash off with soap and plenty of water.
  In case of eye contact
    Flush eyes with water as a precaution.
  If swallowed
    Never give anything by mouth to an unconscious person. Rinse mouth with water.
  Most important symptoms and effects, both acute and delayed
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.
  Indication of any immediate medical attention and special treatment needed
    no data available

Section 5. FIREFIGHTING MEASURES
  Extinguishing media
  Suitable extinguishing media
    Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
  Special hazards arising from the substance or mixture
    Carbon oxides, nitrogen oxides (NOx), Oxides of phosphorus
  Advice for firefighters
    Wear self contained breathing apparatus for fire fighting if necessary.
  Further information
    no data available

Section 6. ACCIDENTAL RELEASE MEASURES
  Personal precautions, protective equipment and emergency procedures
    Avoid dust formation. Avoid breathing vapors, mist or gas.
  Environmental precautions
    Do not let product enter drains.
  Methods and materials for containment and cleaning up
    Sweep up and shovel. Keep in suitable, closed containers for disposal.
  Reference to other sections
    For disposal see section 13.

Section 7. HANDLING AND STORAGE
  Precautions for safe handling
    Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
    protection.
  Conditions for safe storage, including any incompatibilities
    Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
    Recommended storage temperature: -20 °C
  Specific end uses
    no data available

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
  Control parameters
  Components with workplace control parameters
  Exposure controls
  Appropriate engineering controls
    General industrial hygiene practice.
  Personal protective equipment
  Eye/face protection
    Use equipment for eye protection tested and approved under appropriate government standards
    such as NIOSH (US) or EN 166(EU).
  Skin protection
    Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
    (without touching glove's outer surface) to avoid skin contact with this product. Dispose of
    contaminated gloves after use in accordance with applicable laws and good laboratory practices.
    Wash and dry hands.
    The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
    the standard EN 374 derived from it.
  Body Protection
    Choose body protection in relation to its type, to the concentration and amount of dangerous
    substances, and to the specific work-place., The type of protective equipment must be selected
    according to the concentration and amount of the dangerous substance at the specific workplace.
  Respiratory protection
    Respiratory protection is not required. Where protection from nuisance levels of dusts are desired,
    use type N95 (US) or type P1 (EN 143) dust masks. Use respirators and components tested and
    approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
  Information on basic physical and chemical properties
    a) Appearance        Form: crystalline    
    Colour: brown
    b) Odour        no data available    
    c) Odour Threshold        no data available    
    d) pH        no data available    
    e) Melting point/freezing        no data available    
    point
    f) Initial boiling point and no data available
    boiling range
    g) Flash point        no data available    
    h) Evaporation rate        no data available    
    i) Flammability (solid, gas) no data available
    j) Upper/lower        no data available    
    flammability or
    explosive limits
    k) Vapour pressure        no data available    
    l) Vapour density        no data available    
    m) Relative density        no data available    
    n) Water solubility        no data available    
    o) Partition coefficient: n- no data available
    octanol/water
    p) Autoignition        no data available    
    temperature
    q) Decomposition        no data available    
    temperature
    r) Viscosity        no data available    
    s) Explosive properties        no data available    
    t) Oxidizing properties        no data available    
  Other safety information
    no data available

Section 10. STABILITY AND REACTIVITY
  Reactivity
    no data available
  Chemical stability
    no data available
  Possibility of hazardous reactions
    no data available
  Conditions to avoid
    no data available
  Incompatible materials
    Strong oxidizing agents
  Hazardous decomposition products
    Other decomposition products - no data available

Section 11. TOXICOLOGICAL INFORMATION
  Information on toxicological effects
  Acute toxicity
    no data available
  Skin corrosion/irritation
    no data available
  Serious eye damage/eye irritation
    no data available
  Respiratory or skin sensitization
    no data available
  Germ cell mutagenicity
    no data available
  Carcinogenicity
    IARC:        No component of this product present at levels greater than or equal to 0.1% is identified as    
    probable, possible or confirmed human carcinogen by IARC.
  Reproductive toxicity
    no data available
  Specific target organ toxicity - single exposure
    no data available
  Specific target organ toxicity - repeated exposure
    no data available
  Aspiration hazard
    no data available
  Potential health effects
  Inhalation        May be harmful if inhaled. May cause respiratory tract irritation.    
  Ingestion        May be harmful if swallowed.    
  Skin        May be harmful if absorbed through skin. May cause skin irritation.    
  Eyes        May cause eye irritation.    
  Signs and Symptoms of Exposure
    To the best of our knowledge, the chemical, physical, and toxicological properties have not been
    thoroughly investigated.
  Additional Information
    RTECS: Not available

Section 12. ECOLOGICAL INFORMATION
  Toxicity
    no data available
  Persistence and degradability
    no data available
  Bioaccumulative potential
    no data available
  Mobility in soil
    no data available
  Results of PBT and vPvB assessment
    no data available
  Other adverse effects
    no data available

Section 13. DISPOSAL CONSIDERATIONS
  Waste treatment methods
  Product
    Offer surplus and non-recyclable solutions to a licensed disposal company.
  Contaminated packaging
    Dispose of as unused product.

Section 14. TRANSPORT INFORMATION
  UN number
    ADR/RID: -        IMDG: -        IATA: -    
  UN proper shipping name
    ADR/RID: Not dangerous goods
    IMDG: Not dangerous goods
    IATA:        Not dangerous goods    
  Transport hazard class(es)
    ADR/RID: -        IMDG: -        IATA: -    
  Packaging group
    ADR/RID: -        IMDG: -        IATA: -    
  Environmental hazards
    ADR/RID: no        IMDG Marine pollutant: no        IATA: no    
  Special precautions for user
    no data available

Section 15. REGULATORY INFORMATION
    This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
  Safety, health and environmental regulations/legislation specific for the substance or mixture
    no data available
  Chemical Safety Assessment
    no data available

Section 16. OTHER INFORMATION
  Further information
    Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
    only.
    The above information is believed to be correct but does not purport to be all inclusive and shall be
    used only as a guide. The information in this document is based on the present state of our knowledge
    and is applicable to the product with regard to appropriate safety precautions. It does not represent any
    guarantee of the properties of the product. Corporation and its Affiliates shall not be held
    liable for any damage resulting from handling or from contact with the above product. See
     and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

磷酯酰乙醇胺 分子结构与计算化学数据

计算化学数据

1.疏水参数计算参考值(XlogP):-4.4

2.氢键供体数量:2

3.氢键受体数量:9

4.可旋转化学键数量:11

5.互变异构体数量:无

6.拓扑分子极性表面积134

7.重原子数量:19

8.表面电荷:0

9.复杂度:347

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

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河南省郑州市所以化工有限公司

产品介绍:
产品名称:脑磷脂 Cas号:90989-93-8 纯度: 包装信息:洽谈 价格:洽谈
联系方式:
联系人:沈毅 电话:0371-68873668 手机:13938287991

津颂实业有限公司

产品介绍:
产品名称:脑磷脂 Cas号:90989-93-8 纯度: 包装信息:洽谈 价格:洽谈
联系方式:
联系人:杨文娟 电话:021-60343192 手机:13296093192

郑州超凡化工有限公司

产品介绍:
产品名称:脑磷脂 Cas号:90989-93-8 纯度: 包装信息:洽谈 价格:洽谈
联系方式:
联系人:孙祥丽 电话:0371-53796627 手机:18037511376