2-异丙氧基乙醇

外观与性状：

透明无色液体

密度：

0.903 g/mL at 25 °C(lit.)

熔点：

-60 °C

沸点：

42-44 °C13 mm Hg(lit.)

闪点：

114 °F

折射率：

n20/D 1.41(lit.)

蒸汽压：

0.00467mmHg at 25°C

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

避免与强氧化剂、强酸接触。乙二醇一异丙醚对金属无腐蚀性。

其它信息：

1.      性状：无色液体，略有不愉快气味。

2.      密度（g/mL,20/20℃）：0.906

3.      相对蒸汽密度（g/mL,空气=1）：3.6

4.      沸点（ºC,常压）：139~143 

5.      折射率（26ºC）：1.4048

6.      闪点（ºC,开口）：33

7.      蒸气压（kPa,20ºC）：0.80

8.      体膨胀系数（K^-1,10~30ºC）：0.00093

9.      溶解性：能与水和多种有机溶剂混溶。

包装等级：

III

风险类别：

3

海关代码：

2909499000

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R20/21;R36

安全说明：

S24/25

RTECS号：

KL5075000

安全标志：

S24/25:防止皮肤和眼睛接触。

危险标志：

Xn:Harmful;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KL5075000

CHEMICAL NAME :

Ethanol, 2-isopropoxy-

CAS REGISTRY NUMBER :

109-59-1

BEILSTEIN REFERENCE NO. :

1732184

LAST UPDATED :

199712

DATA ITEMS CITED :

27

MOLECULAR FORMULA :

C5-H12-O2

MOLECULAR WEIGHT :

104.17

WISWESSER LINE NOTATION :

Q2OY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,627,1986

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

REFERENCE :

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,627,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5660 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3100 mg/m3/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,67,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,67,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(11),7,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,67,1982

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1930 ppm/7H

TOXIC EFFECTS :

Behavioral - analgesia Lungs, Thorax, or Respiration - dyspnea Kidney, Ureter, Bladder - hematuria

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,157,1943

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1860 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,67,1982

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Unreported

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(11),7,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

1600 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1650 mg/m3/7H/5W-I

TOXIC EFFECTS :

Blood - changes in spleen

REFERENCE :

JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 25,374,1943

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 mg/m3/24H/13W-C

TOXIC EFFECTS :

Endocrine - hypoglycemia Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(11),7,1976

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

142 ppm/6H/4W-I

TOXIC EFFECTS :

Blood - pigmented or nucleated red blood cells Blood - changes in spleen Blood - changes in erythrocyte (RBC) count

REFERENCE :

INHTE5 Inhalation Toxicology. (Hemisphere Publishing Corp., c/o Taylor & Francis Inc., 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.1- 1989- Volume(issue)/page/year: 4,43,1992 *** REVIEWS *** ACGIH TLV-TWA 106 mg/m3 (25 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 25 ppm (105 mg/m3) JAN 1993 OEL-BELGIUM:TWA 25 ppm (106 mg/m3) JAN 1993 OEL-DENMARK:TWA 25 ppm (105 mg/m3) JAN 1993 OEL-FRANCE:TWA 25 ppm (105 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 25 ppm (105 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 25 ppm (110 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7487 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1357 (estimated) No. of Female Employees: 63 (estimated)

毒理学数据：

1、    刺激性：家兔经皮：20mg/24 小时，中度刺激。家兔经眼： 500mg/24 小时，中度刺激。

2、    急性毒性：LD50：500～1000 mg/kg(大鼠经口)；4900 mg/kg(小鼠经口) LC50：3100mg/m3，4小时(大鼠吸入)；1930mg/m3，7小时(小鼠吸入)

3、对肾脏和肝脏有严重损害。滴入兔眼可引起显著的结膜刺激和角膜损伤。长时间与皮肤接触引起明显刺激甚至灼伤。致死剂量可通过皮肤迅速吸收。

生态数据：

总括注解 

水危害级别1（德国规例）（通过名单进行自我评估）该物质对水有稍微危害的。

 不要让未稀释或大量的产品接触地下水、水道或污水系统。 

若无政府许可，勿将材料排入周围环境。

中国海关编码：2909499000

概述：

2909499000 其他醚醇及其卤化、磺化、硝化或亚硝化衍生物. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

分子结构数据

1、   摩尔折射率：58.85

2、   摩尔体积（cm³/mol）：178.1

3、   等张比容（90.2K）：447.5

4、   表面张力（dyne/cm）：39.8

5、   介电常数：

6、   偶极距（10^-24cm³）：

7、   极化率：23.33

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:2

4.可旋转化学键数量:3

5.互变异构体数量:无

6.拓扑分子极性表面积29.5

7.重原子数量:7

8.表面电荷:0

9.复杂度:35.1

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  2-异丙氧基乙醇质谱(MS)
• 
  2-异丙氧基乙醇核磁图(¹³CNMR)
• 
  2-异丙氧基乙醇核磁图(¹HNMR)
• 
  2-异丙氧基乙醇红外图谱(IR1)
• 
  2-异丙氧基乙醇红外图谱(IR2)
• 
  2-异丙氧基乙醇Raman光谱