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非那佐辛
- 基本信息
- 物化性质
- 安全信息
- 毒理性
- 结构与计算化学
- 上游产品
非那佐辛 基本信息
- 中文名称：
- 非那佐辛
- 中文别名：
- 非那佐辛
- 英文名称：
- phenazocine
- 英文别名：
- phenazocine;
Phenethylazocine;
2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan;
Prinadol;
1,2,3,4,5,6-Hexahydro-6,11-diMethyl-3-phenethyl-2,6-Methano-3-benzazocin-8-ol;
Phenobenzorphan;
SKF-6574;
dl-2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan
- CAS No.：
- 127-35-5
- 分 子 式：
- C22H27NO
- 分 子 量：
- 0
- 精确分子量：
- 321.20900
- PSA：
- 23.47000
- EINECS：
- 204-835-3
- InChI：
- The Key: ZQHYKVKNPWDQSL-NKDCDXMNSA-N
- 分子结构式：
-
- SDS：
- 查看
非那佐辛 物化性质
- 密度：
- 1.097g/cm3
- 沸点：
- 461ºC at 760mmHg
- 闪点：
- 220.5ºC
- 折射率：
- 1.59
- 蒸汽压：
- 4.05E-09mmHg at 25°C
非那佐辛 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- PB8890000
- CHEMICAL NAME :
- 2,6-Methano-3-benzazocin-8-ol,
1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-
- CAS REGISTRY NUMBER :
- 127-35-5
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C22-H27-N-O
- MOLECULAR WEIGHT :
- 321.50
- WISWESSER LINE NOTATION :
- T C666 A KN&TTJ A1 B1 EQ K2R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 29 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
Volume(issue)/page/year: 61,83,1961
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1,1,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 56 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPOBAR Research Progress in Organic-Biological and Medicinal Chemistry. (New
York, NY) V.1-3, 1964-72. Discontinued. Volume(issue)/page/year:
2,309,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
Volume(issue)/page/year: NX#02061
非那佐辛 分子结构与计算化学数据
分子结构数据
1、 摩尔折射率：98.89
2、 摩尔体积（cm3/mol）：293.0
3、 等张比容（90.2K）：751.1
4、 表面张力（dyne/cm）：43.1
5、 极化率（10-24cm3）：39.20
