Section 1: Product Identification
Chemical Name: (R)-2-[(Diphenylphosphino)methyl]pyrrolidine, min. 97% (10 wt% in hexanes)
CAS Registry Number: 428514-91-4
Formula: C17H20NP
EINECS Number: none
Chemical Family: organophosphine ligand
Synonym: (R)-2-[(Diphenylphosphano)methyl]pyrrolidine
Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title compound 428514-91-4 10% no data no data
Hexane 73513-42-5 90% 50ppm 1800mg/m3
Section 3: Hazards Identification
Extremely flammable liquid. Vapors irritating to skin, eyes and respiratory tract. Inhalation of vapors may
Emergency Overview:
depress central nervous system causing dizziness, headache and nausea.
Primary Routes of Exposure: Ingestion, inhalation, skin, eyes
Eye Contact: Contact will cause irritation, redness and a burning sensation.
Skin Contact: Contact with skin can result in local irritation. May be absorbed throuh skin.
Inhalation of vapors may depress the central nervous system causing dizziness, difficulty in walking and
Inhalation:
irritation to the lungs.
Ingestion may cause gastrointestinal irritation, nausea, vomiting and headache. May cause lung damage if
Ingestion:
swallowed.
Irritating to skin, eyes and respiratory tract. Harmful by inhalation. Ingestion may cause gastrointestinal
Acute Health Affects:
irritation, nausea, vomiting and headache. Possible risk of harm to the unborn child.
Chronic Health Affects: No information on long-term chronic effects. Possible risk of impaired fertility.
NTP: No
IARC: No
OSHA: No
SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.
SECTION 5: Fire Fighting Measures
Flash Point: -14.8°F (hexane)
Autoignition Temperature: no data
Explosion Limits: LEL (1.7%) UEL (7.7%)
Extinguishing Medium: carbon dioxide, dry powder or foam
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit toxic and irritating fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: Extremely flammable
SECTION 6: Accidental Release Measures
If spilled, all personnel must be immediately evacuated and the area sealed off. The material may self-ignite
Spill and Leak Procedures: releasing toxic and corrosive fumes of phosphorus pentoxide. Ventilation should be available. If entry into the
area is requires, personnel should be fitted with a self-contained breathing apparatus.
SECTION 7: Handling and Storage
Store in a tightly sealed container under an inert atmosphere of nitrogen or argon. Keep away from heat.
Handling and Storage:
Material should be transferred under an inert atmosphere of nitrogen or argon in an efficient fume hood.
SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Wear protective clothing and gloves. Consult with a glove manufacturer to determine the proper type of glove.
Skin Protection:
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: No additional protection required.
SECTION 9: Physical and Chemical Properties
Color and Form: colorless liquid
Molecular Weight: 269.32
Melting Point: no data
Boiling Point: 68°C (hexane)
Vapor Pressure: no data
Specific Gravity: no data
Odor: pungent and noxious
Solubility in Water: Insoluble
SECTION 10: Stability and Reactivity
Stability: air sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: contact with oxidizing agents, ignition sources and prolonged exposure to air
Incompatibility: strong oxidizing agents and halogens
Decomposition Products: carbon monoxide, carbon dioxide, phosphorous pentoxide and organic fumes
SECTION 11: Toxicological Information
No information available on title compound. For hexane -- Standard Draize Test (rabbit); 10mg (mild).
Inhalation (human); TCLo: 190ppm/8W. Oral (rat); LD50: 28710mg/kg. Inhalation (rat); LC50: 48000ppm/4H.
Intraperitoneal (rat); LDLo: 9100mg/kg. Intravenous (mouse); LDLo: 831mg/kg. Inhalation (rat); TCLo:
RTECS Data:
2000ppm/12H/24W-I. Acts a general anesthetic, respiratory depression, altered sleep time, effects on nerves,
decreased weight gain, muscle weakness, and changes to the liver and blood. Toxic effects observed in the
embryo and fetus of test animals.
Carcinogenic Effects: No data
Mutagenic Effects: For hexane: Possible mutagen
Tetratogenic Effects: For hexane: Possible reproductive effector
SECTION 12: Ecological Information
Ecological Information: Toxic to aquatic organisms. May cause long-term adverse effects in the aquatic environment.
SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.
SECTION 14: Transportation
Shipping Name (CFR): Flammable liquids, N.O.S.
Hazard Class (CFR): 3
Additional Hazard Class (CFR): NA
Packaging Group (CFR): I
UN ID Number (CFR): UN# 1993
Shipping Name (IATA): Flammable liquid, N.O.S.
Hazard Class (IATA): 3
Additional Hazard Class (IATA): NA
Packaging Group (IATA): I
UN ID Number (IATA): UN# 1993
SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory
SARA (Title 313): Not reportable under SARA 313
Second Ingredient: Listed on the TSCA inventory. Reportable under SARA 313.
SECTION 16 - ADDITIONAL INFORMATION
N/A
