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- 1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐
1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐
1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐 基本信息
- 中文名称：
- 1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐
- 中文别名：
- 1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐
- 英文名称：
- BEPRIDIL HYDROCHLORIDE
- 英文别名：
- bepridil hydrochloride;
Bepricor;
BEPRIDIL HYDROCHLORIDE;
Einecs 268-472-2;
1978cerm;
1-ISOBUTOXY-2-PYRROLIDINO-3-(N-BENZYLANILINO)PROPANE HCL;
cordium
- CAS No.：
- 68099-86-5
- 分 子 式：
- C24H35ClN2O
- 分 子 量：
- 403
- 精确分子量：
- 402.24400
- PSA：
- 15.71000
- EINECS：
- 268-472-2
- 分子结构式：
-
- SDS：
- 查看
1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐 物化性质
- 密度：
- 1.054g/cm3
- 沸点：
- 492.3ºC at 760 mmHg
- 闪点：
- 133.2ºC
1-异丁氧基-2-吡咯烷基-3-(N-苄基苯胺基)丙烷盐酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY1161000
- CHEMICAL NAME :
- 1-Pyrrolidineethanamine,
beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmeth
yl)-, monohydrochloride
- CAS REGISTRY NUMBER :
- 68099-86-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C24-H34-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 403.06
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6850 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1256,1995
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2069 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo,
Japan) Volume(issue)/page/year: -,1256,1995
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 50600 ug/kg
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 225,133,1977
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7800 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - delayed effects
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,3155,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7800 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - physical
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,3155,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 3300 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 25,3130,1991
