1-(2,3,5-三-O-乙酰基-beta-D-阿拉伯呋喃糖基)-4-氨基嘧啶-2(1H)-酮

密度：

1.52g/cm3

沸点：

507.4ºC at 760 mmHg

闪点：

260.6ºC

折射率：

1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :

HA5600000

CHEMICAL NAME :

Cytosine, 1-beta-D-arabino-furanosyl-, 2',3',5'-triacetate

CAS REGISTRY NUMBER :

6742-07-0

LAST UPDATED :

199606

DATA ITEMS CITED :

8

MOLECULAR FORMULA :

C15-H19-N3-O8

MOLECULAR WEIGHT :

369.37

WISWESSER LINE NOTATION :

T6NVNJ DZ A- BT5OTJ COV1 DOV1 E1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>5010 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4400 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

680 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg/5D-I

TOXIC EFFECTS :

Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

750 mg/kg/15D-I

TOXIC EFFECTS :

Gastrointestinal - hypermotility, diarrhea Blood - changes in bone marrow (not otherwise specified) Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

3 gm/kg/15D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes primarily in glomeruli Blood - thrombocytopenia Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

750 mg/kg/15D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Rodent - mouse Leukocyte

DOSE/DURATION :

49 umol/L

REFERENCE :

CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929- Volume(issue)/page/year: 49,2551,1984