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2-去甲基硫代秋水仙碱 基本信息
- 中文名称：
- 2-去甲基硫代秋水仙碱
- 中文别名：
-
- 英文名称：
- N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
- 英文别名：
- N-[(7S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide;
N-((S)-2-hydroxy-1,3-dimethoxy-10-methylsulfanyl-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide;
N-((S)-2-Hydroxy-1,3-dimethoxy-10-methylmercapto-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid;
2-Demethyl Thiocolchicine;
COLCHICINE,O(sup 2)-DEMETHYL-10-THIO;
(S)-7-Acetylamino-2-hydroxy-1,3-dimethoxy-10-methylmercapto-6,7-dihydro-5H-benzo[a]heptalen-9-on;
O(sup 2)-Demethyl-10-thiocolchicine
- CAS No.：
- 87424-26-8
- 分 子 式：
- C21H23NO5S
- 分 子 量：
- 401.47600
- 精确分子量：
- 401.13000
- PSA：
- 110.16000
- InChI：
- The Key: OMQLBXIHBJAOIO-HNNXBMFYSA-N
- 分子结构式：
-
- SDS：
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2-去甲基硫代秋水仙碱 物化性质
- 密度：
- 1.33g/cm3
- 熔点：
- 218-220ºC
- 沸点：
- 766.8ºC at 760 mmHg
- 闪点：
- 417.6ºC
- 折射率：
- 1.636
2-去甲基硫代秋水仙碱 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0882000
- CHEMICAL NAME :
- Colchicine, O(sup 2)-demethyl-10-thio-
- CAS REGISTRY NUMBER :
- 87424-26-8
- BEILSTEIN REFERENCE NO. :
- 3176298
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C21-H23-N-O5-S
- MOLECULAR WEIGHT :
- 401.51
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intracerebral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25 ug/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 109,386,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 109,386,1957
