依替膦酸二钠

外观与性状：

白色结晶粉末

熔点：

> 300ºC

沸点：

578.8ºC at 760 mmHg

闪点：

303.8ºC

存储条件/存储方法：

密封于2-8ºC阴凉干燥环境。

稳定性相关：

如果遵照规格使用和储存则不会分解。

其它信息：

1.      性状：白色粉末。

2.      密度（g/mL,25/4℃）：无可用

3.      相对蒸汽密度（g/mL,空气=1）：无可用

4.      熔点（ºC）：198-199

5.      沸点（ºC,常压）：无可用

6.      沸点（ºC,5.2kPa）：无可用

7.      折射率：无可用

8.      闪点（ºC）：无可用

9.      比旋光度（º）：无可用

10.   自燃点或引燃温度（ºC）：无可用

11.   蒸气压（kPa,25ºC）：无可用

12.   饱和蒸气压（kPa,60ºC）：无可用

13.   燃烧热（KJ/mol）：无可用

14.   临界温度（ºC）：无可用

15.   临界压力（KPa）：无可用

16.   油水（辛醇/水）分配系数的对数值：无可用

17.   爆炸上限（%,V/V）：无可用

18.   爆炸下限（%,V/V）：无可用

19.   溶解性：易溶于水和乙醇，吸湿性强。耐酸碱性、耐氯氧化性能较其他有机膦酸（盐）好。在高PH值下仍很稳定，不易水解，一般光热条件下不易分解。可与水中金属离子，尤其是钙离子形成六圆环螯合物，因而具较好的阻垢效果并具明显的溶限效应，当和其他水处理剂复合使用时，表现出理想的协同效应。

危险类别码：

R22

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SZ8562240

CHEMICAL NAME :

Phosphonic acid, (1-hydroxyethylidene)di-, disodium salt

CAS REGISTRY NUMBER :

7414-83-7

LAST UPDATED :

199806

DATA ITEMS CITED :

22

MOLECULAR FORMULA :

C2-H6-O7-P2.2Na

MOLECULAR WEIGHT :

250.00

WISWESSER LINE NOTATION :

QPQOYQ1OPQQ &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

588 mg/kg/28W-I

TOXIC EFFECTS :

Musculoskeletal - osteomalacia Musculoskeletal - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1340 mg/kg

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in both tubules and glomeruli

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

372 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - chromodacryorrhea Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

73 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - ptosis Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

260 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

49 mg/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - ataxia Gastrointestinal - nausea or vomiting

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

32 mg/kg

TOXIC EFFECTS :

Cardiac - arrhythmias (including changes in conduction) Cardiac - pulse rate increase, without fall in BP Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

581 mg/kg

TOXIC EFFECTS :

Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - interstitial nephritis

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

72800 mg/kg/26W-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - changes in both tubules and glomeruli Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in calcium

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

14560 mg/kg/13W-C

TOXIC EFFECTS :

Endocrine - other changes Blood - other changes Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

14560 mg/kg/52W-I

TOXIC EFFECTS :

Behavioral - ataxia Kidney, Ureter, Bladder - changes in bladder weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphokinase

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

2500 mg/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

5500 mg/kg

SEX/DURATION :

female 1-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - other measures of fertility

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

86 gm/kg

SEX/DURATION :

male 9 week(s) pre-mating female 2 week(s) pre-mating female 1-7 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

11 gm/kg

SEX/DURATION :

female 7-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - live birth index (measured after birth)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

7800 mg/kg

SEX/DURATION :

female 17-22 day(s) after conception lactating female 20 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - physical

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1500 ug/kg

SEX/DURATION :

female 2-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

MUTATION DATA

TYPE OF TEST :

Cytogenetic analysis

TEST SYSTEM :

Rodent - hamster Ovary

DOSE/DURATION :

1 mmol/L

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 23,1343,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2888 No. of Facilities: 78 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 1099 (estimated)

毒理学数据：

1。
试验方法：口服
摄入剂量：240mg/kg/26W-I
测试对象：人-女人
毒性类型：急性
毒性作用：1.改变视力
2.耳鸣
2。
试验方法：口服
摄入剂量：588mg/kg/28W-I
测试对象：人-女人
毒性类型：急性
毒性作用：1.骨软化
2。发生其他变化

3。
试验方法：口服
摄入剂量：240mg/kg/22W-I
测试对象：人-女人
毒性类型：急性
毒性作用：1.改变视力
2.耳鸣

生态数据：

通常对水是不危害的，若无政府许可，勿将材料排入周围环境。

分子结构数据

1、  摩尔折射率：无可用

2、  摩尔体积（cm³/mol）：无可用

3、  等张比容（90.2K）：无可用

4、  表面张力（dyne/cm）：无可用

5、  极化率：无可用

计算化学数据

1、  疏水参数计算参考值（XlogP）：无可用

2、  氢键供体数量：3

3、  氢键受体数量：7

4、  可旋转化学键数量：2

5、  拓扑分子极性表面积（TPSA）：141

6、  重原子数量：13

7、  表面电荷：0

8、  复杂度：206

9、  同位素原子数量：0

10、  确定原子立构中心数量：0

11、  不确定原子立构中心数量：0

12、  确定化学键立构中心数量：0

13、  不确定化学键立构中心数量：0

14、  共价键单元数量：3