亮甲酚蓝

  • 基本信息
  • 制备方法及用途
  • 物化性质
  • 安全信息
  • 毒理性
  • MSDS
  • 结构与计算化学

亮甲酚蓝 基本信息

中文名称:
亮甲酚蓝 
中文别名:
亮甲酚蓝;
灿烂甲酚蓝 甲酚蓝 黄焦油蓝 
英文名称:
Phenoxazin-5-ium,1,3-diamino-7-(diethylamino)-8-methyl-, chloride (1:1)
英文别名:
BRILLIANT CRESYL BLUE;
CRESYL BLUE 2RN;
Brilliant cresyl Blue-BB;
BRILLIANT BLUE C;
Brilliant cresyl Blue-BB,certified,pure;
Brilliant cresyl Blue-BB,pure,certified 
CAS No.:
10127-36-3
分 子 式:
C17H21N4O.Cl
分 子 量:
332.82
精确分子量:
332.14000
PSA:
81.31000
EINECS:
233-358-3
风险术语:
R36/37/38; R20/21/22
安全术语:
S28S37S45S24/25
分子结构式:
SDS:
查看

亮甲酚蓝 制备方法及用途

制备方法

活体染色剂(指示氧化还原电位)。血液染色(检查血小板和网状细胞)。氧化还原指示剂(蓝色~无色)。棉布印花。

用途简介

亮甲酚蓝 物化性质

折射率:
1.646
蒸汽压:
1.72E-08mmHg at 25°C
存储条件/存储方法:
库房通风低温干燥
稳定性相关:

遵照规定使用和储存则不会分解。

其它信息:

1.       性状:无可用

2.       密度(g/mL,25/4):无可用

3.       相对蒸汽密度(g/mL,空气=1):无可用

4.       熔点(ºC):无可用

5.       沸点(ºC,常压):无可用

6.       沸点(ºC,5.2kPa):无可用

7.       折射率:无可用

8.       闪点(ºC):无可用

9.       比旋光度(º):无可用

10.    自燃点或引燃温度(ºC):无可用

11.    蒸气压(kPa,25ºC):无可用

12.    饱和蒸气压(kPa,60ºC):无可用

13.    燃烧热(KJ/mol):无可用

14.    临界温度(ºC):无可用

15.    临界压力(KPa):无可用

16.    油水(辛醇/水)分配系数的对数值:无可用

17.    爆炸上限(%,V/V):无可用

18.    爆炸下限(%,V/V):无可用

19.    溶解性:无可用

亮甲酚蓝 安全信息

WGK_Germany:
3
德国有关水污染物质的分类清单
危险类别码:
36/37/38-20/21/22
安全说明:
S28-S37-S45-S24/25
安全标志:
S28:接触皮肤之后,立即使用大量皂液洗涤。
S37:使用合适的防护手套。
S45:出现意外或者感到不适,立刻到医生那里寻求帮助(最好带去产品容器标签)。
S24/25:防止皮肤和眼睛接触。

亮甲酚蓝 毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP7693500
CHEMICAL NAME :
Phenoxazin-5-ium, 1,3-diamino-7-(diethylamino)-8-methyl-, chloride
CAS REGISTRY NUMBER :
10127-36-3
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C17-H21-N4-O.Cl
MOLECULAR WEIGHT :
332.87

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
32 mg/kg
TOXIC EFFECTS :
Behavioral - aggression

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 umol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
毒理学数据:

试验方法:静脉
摄入剂量: 32毫克/千克
测试对象:啮齿动物-
毒性类型:急性
毒性作用: 行为不受约束

生态数据:

该物质对环境可能有危害,对水体应给予特别注意。

亮甲酚蓝 MSDS

Name: Brilliant cresyl blue-bb (cert) Material Safety Data Sheet
Synonym: 1,3-Diamo-7-(Diethylamino)-8-Methylphenoxazin-5-ium chloride; Phenoxazin-5-ium,1,3-Diamino-7-(Diethylamineo)-8-methyl-, chloride
CAS: 10127-36-3
Section 1 - Chemical Product   MSDS Name:Brilliant cresyl blue-bb (cert) Material Safety Data Sheet
Synonym:1,3-Diamo-7-(Diethylamino)-8-Methylphenoxazin-5-ium chloride; Phenoxazin-5-ium,1,3-Diamino-7-(Diethylamineo)-8-methyl-, chloride

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
10127-36-3 Brilliant cresyl blue-bb (cert) 100.0 233-358-3
Hazard Symbols: None Listed.
Risk Phrases: None Listed.

Section 3 - HAZARDS IDENTIFICATION
  EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

Section 4 - FIRST AID MEASURES
  Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water.
Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Antidote: None reported.

Section 5 - FIRE FIGHTING MEASURES
  General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
  General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation.

Section 7 - HANDLING and STORAGE
  Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a cool, dry place. Keep container closed when not in use.
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
  Engineering Controls:
Use adequate ventilation to keep airborne concentrations low. Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels.
Exposure Limits CAS# 10127-36-3: Personal Protective Equipment Eyes: Wear chemical splash goggles. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin. Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES
 
Physical State: Not available.
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: N/A
Explosion Limits, upper: N/A
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C17H21ClN4O
Molecular Weight: 332.82

Section 10 - STABILITY AND REACTIVITY
  Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Oxides of nitrogen, irritating and toxic fumes and gases, chloride fumes.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
  RTECS#:
CAS# 10127-36-3: SP7693500 LD50/LC50:
Not available.
Carcinogenicity:
Brilliant cresyl blue-bb (cert) - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

Section 12 - ECOLOGICAL INFORMATION
  Other No information available.

Section 13 - DISPOSAL CONSIDERATIONS
  Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION
 
IATA
Not regulated as a hazardous material.
IMO
Not regulated as a hazardous material.
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION
 
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
S 28A After contact with skin, wash immediately with
plenty of water.
S 37 Wear suitable gloves.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 10127-36-3: No information available.
Canada
CAS# 10127-36-3 is listed on Canada's DSL List.
CAS# 10127-36-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 10127-36-3 is listed on the TSCA inventory.


SECTION 16 - ADDITIONAL INFORMATION
N/A

亮甲酚蓝 分子结构与计算化学数据

分子结构数据

1摩尔折射率:无可用

2、   摩尔体积(cm3/mol):无可用       

3、   等张比容(90.2K):无可用

4、   表面张力(dyne/cm):无可用

5、   极化率:无可用

计算化学数据

1、   疏水参数计算参考值(XlogP):无可用

2、   氢键供体数量:2

3、   氢键受体数量:5

4、   可旋转化学键数量:2

5、   拓扑分子极性表面积(TPSA):76.6

6、   重原子数量:23

7、   表面电荷:0

8、   复杂度:582

9、   同位素原子数量:0

10、   确定原子立构中心数量:0

11、   不确定原子立构中心数量:0

12、   确定化学键立构中心数量:0

13、   不确定化学键立构中心数量:0

14、   共价键单元数量:2

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