甲磺酸多拉司琼

外观与性状：

白色粉末

沸点：

535.1ºC at 760 mmHg

闪点：

277.4ºC

蒸汽压：

1.65E-22mmHg at 25°C

危险类别码：

R20/21/22

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NL6015300

CHEMICAL NAME :

1H-Indole-3-carboxylic acid, octahydro-3-oxo-2,6-methano-2H-quinolizin-8-yl ester, (2-alpha,6-alpha,8-alpha,9a-beta)-, monomethanesulfonate, monohydrate

CAS REGISTRY NUMBER :

115956-13-3

LAST UPDATED :

199801

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C19-H20-N2-O3.C-H4-O3-S.H2-O

MOLECULAR WEIGHT :

438.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

2400 ug/kg

TOXIC EFFECTS :

Behavioral - headache Gastrointestinal - decreased motility or constipation Gastrointestinal - other changes

REFERENCE :

BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

2400 ug/kg/10M-C

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions Behavioral - headache

REFERENCE :

BDDID8 Biopharmaceutics & Drug Disposition. (John Wiley & Sons, Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1979- Volume(issue)/page/year: 18,361,1997

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

545 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

165 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 18,506,1993