盐酸哌立度酯

沸点：

431.9ºC at 760mmHg

闪点：

136ºC

蒸汽压：

1.16E-07mmHg at 25°C

其它信息：

1.         性状：无色可燃液体。

2.         密度（g/mL ,25/4℃）：0.7681

3.         折射率（nD20）：1.3900

4.         闪点（℃）：-15

5.         熔点（℃）：-112

6.         沸点（ºC）：83

7.         溶解性：易溶于乙醇和乙醚，微溶于水。

8.         稳定性：化学性质活泼，易发生加成和聚合反应，易被酸水解为乙醛和异丁醇。

海关代码：

2933399090

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AH2975000

CHEMICAL NAME :

Acetic acid, diphenyl-, 1-ethyl-3-piperidyl ester, hydrochloride

CAS REGISTRY NUMBER :

129-77-1

LAST UPDATED :

199603

DATA ITEMS CITED :

4

MOLECULAR FORMULA :

C21-H25-N-O2.Cl-H

MOLECULAR WEIGHT :

359.93

WISWESSER LINE NOTATION :

T6NTJ A2 COVYR&R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

19 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1040 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

26 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,269,1952

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

35 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

毒理学数据：

1、急性毒性： 大鼠经静脉LD5O：19mg/kg

小鼠经口LD5O：1040mg/kg

小鼠经静脉LD5O：26mg/kg

狗经静脉LD5O：35mg/kg

 

中国海关编码：2933399090

概述：

2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

摘要/Summary：

2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:1

3.氢键受体数量:3

4.可旋转化学键数量:6

5.互变异构体数量:无

6.拓扑分子极性表面积29.5

7.重原子数量:25

8.表面电荷:0

9.复杂度:367

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2