甲二醇乙醚乙酸酯

外观与性状：

无色液体

密度：

1.009 g/mL at 25 °C(lit.)

熔点：

−65 °C(lit.)

沸点：

145 °C(lit.)

闪点：

111 °F

折射率：

n20/D 1.402(lit.)

蒸汽压：

2.14mmHg at 25°C

存储条件/存储方法：

库房通风低温干燥,与氧化剂分开存放

稳定性相关：

1.稳定性^[18]  稳定

2.禁配物^[19]  酸类、碱类、强氧化剂

3.聚合危害^[20]  不聚合

其它信息：

1.性状：无色液体，略有醚样的气味。^[1]

2.熔点（℃）：-65.1^[2]

3.沸点（℃）：143^[3]

4.相对密度（水=1）：1.01（20℃）^[4]

5.相对蒸气密度（空气=1）：4.07^[5]

6.饱和蒸气压（kPa）：0.27（20℃）^[6]

7.辛醇/水分配系数：0.121^[7]

8.闪点（℃）：45（CC）：55.6（OC）^[8]

9.引燃温度（℃）：392^[9]

10.爆炸上限（%）：12.3^[10]

11.爆炸下限（%）：1.5^[11]

12.溶解性：溶于水，可混溶于多数有机溶剂。^[12]

13.折射率（20ºC）：1.4022

14.折射率（25ºC）：1.4025

15.黏度（mPa·s,20ºC）：1.08

16.闪点（ºC,闭口）：56

17.闪点（ºC,开口）：60

18.蒸发热（KJ/mol,b.p.）：44.0

19.比热容（KJ/(kg·K),30ºC,定压）：2.08

20.蒸气压（kPa,25ºC）：0.67

21.蒸气压（kPa,42ºC）：1.33

22.蒸气压（kPa,71ºC）：6.67

包装等级：

III

风险类别：

3

海关代码：

2915390090

WGK_Germany：

1
德国有关水污染物质的分类清单

危险类别码：

R20/21/22;R60;R61

安全说明：

S53-S45

RTECS号：

KL5950000

安全标志：

S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S53:避免暴露——使用前先阅读专门的说明。

危险标志：

T:Toxic

CHEMICAL IDENTIFICATION

RTECS NUMBER :

KL5950000

CHEMICAL NAME :

Ethanol, 2-methoxy-, acetate

CAS REGISTRY NUMBER :

110-49-6

BEILSTEIN REFERENCE NO. :

1700761

LAST UPDATED :

199712

DATA ITEMS CITED :

49

MOLECULAR FORMULA :

C5-H10-O3

MOLECULAR WEIGHT :

118.15

WISWESSER LINE NOTATION :

1VO2O1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

1000 mg/m3

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - cough Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2900 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

7000 ppm/4H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1200 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Behavioral - muscle weakness Kidney, Ureter, Bladder - renal function tests depressed

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3100 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory depression

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

6 gm/m3/7H

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Behavioral - food intake (animal) Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

5250 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Behavioral - general anesthetic Gastrointestinal - other changes Kidney, Ureter, Bladder - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

5 gm/kg

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

12500 mg/kg

SEX/DURATION :

male 25 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

50 gm/kg

SEX/DURATION :

male 25 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

9800 mg/kg

SEX/DURATION :

female 7-14 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

9800 mg/kg

SEX/DURATION :

female 6-13 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

TYPE OF TEST :

Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TEST SYSTEM :

Yeast - Saccharomyces cerevisiae

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 149,339,1985 *** REVIEWS *** ACGIH TLV-TWA 24 mg/m3 (5 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 25 ppm (120 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,159,1971 OSHA PEL (Gen Indu):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 25 ppm (120 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-BELGIUM:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-DENMARK:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-FINLAND:TWA 25 ppm (120 mg/m3);STEL 40 ppm (180 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 5 ppm (24 mg/m3) JAN 1993 OEL-GERMANY:TWA 5 ppm (25 mg/m3);Skin JAN 1993 OEL-HUNGARY:TWA 25 mg/m3;STEL 50 mg/m3;Skin JAN 1993 OEL-JAPAN:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-THE NETHERLANDS:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:TWA 5 ppm JAN 1993 OEL-SWEDEN:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-SWITZERLAND:TWA 5 ppm (25 mg/m3);STEL 10 ppm (50 mg/m3);Skin JAN 1993 OEL-TURKEY:TWA 25 ppm (120 mg/m3);Skin JAN 1993 OEL-UNITED KINGDOM:TWA 5 ppm (24 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO EGMEA-air:10H TWA 0.1 ppm (Sk) REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 46935 No. of Facilities: 2907 (estimated) No. of Industries: 45 No. of Occupations: 49 No. of Employees: 20492 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 46935 No. of Facilities: 658 (estimated) No. of Industries: 20 No. of Occupations: 27 No. of Employees: 9892 (estimated) No. of Female Employees: 2801 (estimated)

毒理学数据：

1、刺激性：兔子眼睛：218mg   轻微刺激；

2、急性毒性：大鼠经口LD50：3400mg/kg；小鼠经口LD50：3100mg/kg；豚鼠经口LD50：1250mg/kg；大鼠吸入LCLo：7000ppm/4H；猫吸入LCLo：6000mg/m3/7H；兔子皮肤LD50：5250ul/kg；

3、对皮肤和眼稍有刺激，长期接触可通过皮肤吸收。工作场所最高容许浓度120mg/m3。

4.急性毒性^[13]

LD50：2900mg/kg（大鼠经口）；5250mg/kg（兔经皮）

5.刺激性^[14]  家兔经眼：218mg，轻度刺激。

生态数据：

1.生态毒性^[15] 

LC50：45mg/L（96h）（蓝鳃太阳鱼，静态）；40mg/L（96h）（月银汉鱼，静态）

2.生物降解性^[16]  MITI-I测试，初始浓度100mg/L，污泥浓度30mg/L，2周后降解95%。

3.非生物降解性^[17]  空气中，当羟基自由基浓度为5.00×10⁵个/cm³时，降解半衰期为1.2d（理论）。当pH值为7，8时，水解半衰期分别为391，32d（理论）。

中国海关编码：2915390090

概述：

2915390090. 其他乙酸酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

监管条件：

A.入境货物通关单B.出境货物通关单

检验检疫：

R.进口食品卫生监督检验S.出口食品卫生监督检验M.进口商品检验N.出口商品检验

摘要/Summary：

2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%

分子结构数据

1、摩尔折射率：28.73

2、摩尔体积（cm³/mol）：120.9

3、等张比容（90.2K）：275.4

4、表面张力（dyne/cm）：26.9

5、极化率（10^-24cm³）：11.39

计算化学数据

1.疏水参数计算参考值（XlogP）:0

2.氢键供体数量:0

3.氢键受体数量:3

4.可旋转化学键数量:4

5.互变异构体数量:无

6.拓扑分子极性表面积35.5

7.重原子数量:8

8.表面电荷:0

9.复杂度:70.1

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  2-甲氧基乙基乙酸酯核磁图(¹HNMR)
• 
  2-甲氧基乙基乙酸酯Raman光谱
• 
  2-甲氧基乙基乙酸酯核磁图(¹³CNMR)
• 
  2-甲氧基乙基乙酸酯质谱(MS)
• 
  2-甲氧基乙基乙酸酯红外图谱(IR2)
• 
  2-甲氧基乙基乙酸酯红外图谱(IR1)