乳糖酸阿奇霉素

基本信息
制备方法及用途
物化性质
毒理性
上游产品

乳糖酸阿奇霉素基本信息

中文名称：: 乳糖酸阿奇霉素

中文别名：: 乳糖酸红霉素;
糖酸罗红霉素;
红霉素乳糖醛酸

英文名称：: ERYTHROMYCIN LACTOBIONATE (200 MG)

英文别名：: ERYTHROMYCIN LACTOBIONATE (200 MG);
Erythromycin,lactobionate (1:1) (salt);
Erythrocin lactobionate;
Azithromycin lactobionate;
Erythomycin lactobionate;
Erythromycin,compd. with lactobionic acid (7CI);
lactobionicacid,compd.witherythromycin(1:1);
erythromycin lactobionate;
lactobionic acid,compd. with erythromycin;
ERYTHROMYCIN LACTOBIONATE USP(CRM STANDARD)

CAS No.：: 3847-29-8

分子式：: C37H67NO13.C12H22O12

分子量：: 1092.22

精确分子量：: 1091.57000

PSA：: 411.51000

EINECS：: 223-348-7

InChI：: InChI=1/C37H67NO13.C12H22O12/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26;13-1-3(15)10(7(18)8(19)11(21)22)24-12-9(20)6(17)5(16)4(2-14)23-12/h18-26

危险品标志：

风险术语：

安全术语：

分子结构式：

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乳糖酸阿奇霉素制备方法及用途

制备方法

治疗鼻窦炎、中耳炎及败血症、猩红热及其他由肺炎双球菌引起的炎症等。

用途简介

乳糖酸阿奇霉素物化性质

沸点：: 818.4ºC at 760mmHg
闪点：: 448.8ºC

乳糖酸阿奇霉素毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OD7320000

CAS REGISTRY NUMBER :: 3847-29-8

LAST UPDATED :: 199712

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C37-H67-N-O13.C12-H22-O12

MOLECULAR WEIGHT :: 1092.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 61 mg/kg/1D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - tinnitus Sense Organs and Special Senses (Ear) - changes in vestibular functions

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 60 mg/kg/1D-I

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate increase, without fall in BP

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 240 mg/kg/4D-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Ear) - change in acuity

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 735 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 50 gm/kg/6W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

MUTATION DATA

TYPE OF TEST :: Gene conversion and mitotic recombination

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 1 gm/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 12,357,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3884 No. of Facilities: 98 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 3317 (estimated) No. of Female Employees: 1523 (estimated)