硫酸长春地辛

基本信息
制备方法及用途
物化性质
安全信息
毒理性

硫酸长春地辛基本信息

中文名称：: 硫酸长春地辛

中文别名：: 硫酸长春地辛;
2-bromo-1-fluoro-3-methylbenzene;
3-Fluoro-2-Bromo Toluene;
4-chloro-2,3-dimethylpyridine 1-oxide;
2,3-Dimethyl-4-chloropyridine-N-oxide;
1,3-双(二苯基磷)丙烷二氯化钯;
1,3-双(二苯基膦)丙烷氯化钯;
双(1,3-二苯基膦)丙基二氯化钯 (II);
5-isobenzofurancarbonitrile,1,3-dihydro-1-(3-(dimethylamino)propyl)-1-(4-fluor;
cipram;
N,N-dimethylamino-3-chloropropane HCL;
1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3;
5-Isobenzofurancarbonitrile, 1-3-(dimethylamino)propyl-1-(4-fluorophenyl)-1,3-

英文名称：: vindesine sulfate

英文别名：: vindesine sulfate;
Vindesine Sulfate Salt;
Vindesine sulphate

CAS No.：: 59917-39-4

分子式：: C₄₃H₅₅N₅O₇.H₂SO₄

分子量：: 852.01

精确分子量：: 851.37800

PSA：: 247.80000

EINECS：: 261-984-7

InChI：: InChI=1/C43H55N5O7.H2O4S/c1-6-39(52)21-25-22-42(38(51)55-5,33-27(13-17-47(23-25)24-39)26-11-8-9-12-30(26)45-33)29-19-28-31(20-32(29)54-4)46(3)35-41(28)15-18-48-16-10-14-40(7-2,34(41)48)36(49)43(35,53)37(44)50;1-5(2,3)4/h8-12,14,19-20,25,34-36,45,49,52-53H

危险品标志：

风险术语：

安全术语：

分子结构式：

SDS：: 查看

硫酸长春地辛制备方法及用途

制备方法

方法1:同样以长春碱为原料,在常压下和无水肼反应生成肼化物,经二氯甲烷萃取后得干燥品。溶于THF,加入盐酸,在0℃滴加亚硝酸丁酯,生成叠氮化合物,再加入三苯基膦的THF溶液。去除杂质后,用氨水中和,然后用二氯甲烷萃取,真空蒸干,用柱层析或高压液相分离即得长春地辛。方法2:长春碱在无水甲醇溶液中,加入无水液氨,于100℃和加压下。进行约60h的氨解水解。反应完毕后,真空蒸发至干,柱层析分离得到长春地辛。方法3:同样以长春碱为原料,在常压下,和无水肼反应后再还原得到长春地辛。

用途简介

抗癌药。

硫酸长春地辛物化性质

外观与性状：: 非晶形的固体
密度：: 1.41 g/cm3
熔点：: >250ºC

硫酸长春地辛安全信息

包装等级：: II
风险类别：: 6.1(a)
海关代码：: 2942000000
危险类别码：: R40
安全说明：: 26-36
危险标志：: Xn: Harmful;

硫酸长春地辛毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YY8090000

CAS REGISTRY NUMBER :: 59917-39-4

LAST UPDATED :: 199706

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C43-H55-N5-O7.H2-O4-S

MOLECULAR WEIGHT :: 852.11

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1050 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1790 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 ug/kg

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased Blood - normocytic anemia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - urine volume increased

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1250 ug/kg/33D-I

TOXIC EFFECTS :: Endocrine - other changes Blood - changes in bone marrow (not otherwise specified) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 1250 ug/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

TYPE OF TEST :: Micronucleus test

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 28 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,2886,1978