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芬纳西泮
- 基本信息
- 制备方法及用途
- 物化性质
- 安全信息
- 毒理性
- 上游产品
- 下游产品
芬纳西泮 基本信息
- 中文名称：
- 芬纳西泮
- 中文别名：
- 芬纳西泮;
5-(2-氯苯基)-7-溴-1,4-苯并二氮杂卓-2-酮;
7-溴-5-(2-氯苯基)-1,3-二氢-3H-1,4-苯并二氮杂卓-2-酮;
7-溴-5-(2-氯苯基)-1,3-二氢-2H-1,4-苯并二氮杂卓-2-酮;
5-(2-氯苯基)-7-溴-1,4-苯并二氮杂卓
- 英文名称：
- Phenazepam
- 英文别名：
- 7-Bromo-5-(2-Chlorophenyl)-1,3-Dihydro-2H-1,4-Benzodiazepin-2-One;
7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one;
7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-3H-1,4-benzodiazepin-2-one
- CAS No.：
- 51753-57-2
- 分 子 式：
-
C15H10BrClN2O
- 分 子 量：
- 349.61
- 精确分子量：
- 345.95100
- PSA：
- 42.85000
- EINECS：
- 200-835-2
- InChI：
- The Key: CGMJQQJSWIRRRL-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
芬纳西泮 制备方法及用途
制备方法
为精神病类药物,药性相对较强。
用途简介
芬纳西泮 物化性质
- 外观与性状：
- 白色或灰白色结晶粉末
- 密度：
- 1.61 g/cm3
- 熔点：
- 225-230ºC
- 沸点：
- 493ºC at 760 mmHg
- 闪点：
- 251.9ºC
- 折射率：
- 1.691
芬纳西泮 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DE9770000
- CHEMICAL NAME :
- 2H-1,4-Benzodiazepin-2-one,
7-bromo-5-(2-chlorophenyl)-1,3-dihydro-
- CAS REGISTRY NUMBER :
- 51753-57-2
- BEILSTEIN REFERENCE NO. :
- 0889456
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C15-H10-Br-Cl-N2-O
- MOLECULAR WEIGHT :
- 349.63
- WISWESSER LINE NOTATION :
- T67 GMV JN IHJ CE KR BG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 720 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 13(10),108,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 13(10),108,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal.
For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095
Moscow, USSR) V.1- 1967- Volume(issue)/page/year: 13(10),108,1979
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 70 mg/kg
- SEX/DURATION :
- female 16-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 43,299,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 260 mg/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
lactating female 5 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and
Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049
Moscow, Russia) V.55- 1992- Volume(issue)/page/year: 56(6),6,1993
