Section 1. Chemical Product and Company Identification
Ergotamine Tartrate
Common Name/
Trade Name
Ergotamine Tartrate
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. WARM water MUST be used. Get medical attention if irritation
occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on When heated to decomposition it emits toxic fumes of Nitrogen oxide
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Ergotamine Tartrate
Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately and
show the container or the label. Keep away from incompatibles such as oxidizing agents.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area. Do not store above 8°C (46.4°F).
Refrigerate.
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Crystalline powder.) Odor Not available.
Taste Not available.
Molecular Weight 1313.41 g/mole
Color White. White to yellowish.
pH (1% soln/water) Not available.
Not available.
Boiling Point
Melting Point Decomposition temperature: 203°C (397.4°F)
Not available.
Critical Temperature
Specific Gravity Not available.
Vapor Pressure Not applicable.
Vapor Density Not available.
Volatility Not available.
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Ionicity (in Water) Not available.
Dispersion Properties Not available.
Solubility Very slightly soluble in cold water.
Solubility in Water: 0.1%
Solubility in Ethanol: 0.1%
Section 10. Stability and Reactivity Data
Stability The product is stable.
Instability Temperature Not available.
Conditions of Instability Excess heat, incompatible materials, light
Incompatibility with various Reactive with oxidizing agents.
substances
Ergotamine Tartrate
Not available.
Corrosivity
Special Remarks on Sensitive to light.
Reactivity
Special Remarks on Not available.
Corrosivity
Will not occur.
Polymerization
Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans DEVELOPMENTAL TOXICITY: Classified Reproductive system/toxin/female, Reproductive system/toxin/male
[SUSPECTED].
May cause damage to the following organs: the reproductive system, cardiovascular system, central nervous
system (CNS).
Other Toxic Effects on Hazardous in case of ingestion.
Humans Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on May affect genetic material (mutagenic).
Chronic Effects on Humans May cause adverse reproductive effects and birth defects (teratogenic)
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation. May cause systemic effects similar to that of ingestion.
Ingestion: Harmful if swallowed. May cause dry mouth, stomach pain/abdominal cramps, nausea, vomiting,
diarrhea. May affect behavior/central nervous system/nervous system (headache, ataxia, dizziness, lanxiety,
lethargy, slurred speech, euphoria, insomniadrowsiness, confusion, mental instability, hallucinations, convulsions,
muscle contraction or spasticity, facial and peripheral nerve palsies, weakness, one-sided paralysis),
cardiovascular system (chest pain, change in heart rate(tachycardia or bradycardia) or blood pressure
(hypertension or hypotension), weak pulse, myocardial fibrosis), liver(hepatitis), kidneys(renal failure - hematuria,
oliguria). May also cause visual changes, cyanosis (may occur secondary to peripheral ischemia), cold or itching
skin, numbness, peripheral circulatory disturbances, gangrene , tingling or swollen extremities, shortness of
breath, respiratory depression, and loss of consciousness.
Chronic Potential Health Effects:
Ingestion: Prolonged or repeated ingestion may affect behavior/central nervous system/nervous system, and
cardiovascular system with similar symptoms as acute ingestion.
Medical Conditions Aggravated by Exposure: Hypersensitivity to material, cardiovascular disease, recent or
contemplated angioplasty, hypertension, severe itching, sepis or other severe infection, and impaired kidney or
liver function.
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are less toxic than the product itself.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation
Ergotamine Tartrate
Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
California prop. 65: This product contains the following ingredients for which the State of California has found to
Federal and State
cause cancer, birth defects or other reproductive harm, which would require a warning under the statute:
Regulations
Ergotamine Tartrate
California prop. 65: This product contains the following ingredients for which the State of California has found to
cause birth defects which would require a warning under the statute: Ergotamine Tartrate
Illinois chemical safety act: Ergotamine Tartrate
New York release reporting list: Ergotamine Tartrate
Pennsylvania RTK: Ergotamine Tartrate
Massachusetts RTK: Ergotamine Tartrate
Massachusetts spill list: Ergotamine Tartrate
New Jersey: Ergotamine Tartrate
New Jersey spill list: Ergotamine Tartrate
Louisiana RTK reporting list: Ergotamine Tartrate
TSCA 8(b) inventory: Ergotamine Tartrate
SARA 302/304/311/312 extremely hazardous substances: RQ = 500 lbs.: Ergotamine Tartrate
California
California prop. 65: This product contains the following ingredients for which the State of California has found
Proposition 65
to cause birth defects which would require a warning under the statute: Ergotamine Tartrate
Warnings
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada) CLASS D-2A: Material causing other toxic effects (VERY TOXIC).
Other Classifications
DSCL (EEC) R22- Harmful if swallowed. S36- Wear suitable protective clothing.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
Ergotamine Tartrate
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent. Wear appropriate respirator
when ventilation is inadequate.
SECTION 16 - ADDITIONAL INFORMATION
N/A
T