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卡普托胺 基本信息
- 中文名称：
- 卡普托胺
- 中文别名：
- 卡普托胺
- 英文名称：
- Ethanamine,2-[[[4-(butylthio)phenyl]phenylmethyl]thio]-N,N-dimethyl-
- 英文别名：
- 2-[(4-butylsulfanylphenyl)-phenylmethyl]sulfanyl-N,N-dimethylethanamine;
N,N-Dimethyl-2-(4-butylmercapto-benzhydrylmercapto)-ethylamin;
Captodiamin;
Kaptodiamin [Czech];
Captodiamine;
[2-(4-Butylmercapto-benzhydrylmercapto)-aethyl]-dimethyl-amin;
Captodramine;
Captodiame;
Covatin;
Captodramin;
Captodiamum [INN-Latin];
Captodiamo [INN-Spanish];
[2-(4-butylsulfanyl-benzhydrylmercapto)-ethyl]-dimethyl-amine;
1-(4-Butylmercapto-benzhydrylmercapto)-2-dimethylamino-ethan;
Covatix
- CAS No.：
- 486-17-9
- 分 子 式：
-
C21H29NS2
- 分 子 量：
- 359.59
- 精确分子量：
- 359.17400
- PSA：
- 53.84000
- EINECS：
- 207-629-1
- InChI：
- The Key: IZLPZXSZLLELBJ-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
卡普托胺 物化性质
- 密度：
- 1.08g/cm3
- 沸点：
- 466.1ºC at 760mmHg
- 闪点：
- 235.7ºC
- 折射率：
- 1.596
- 蒸汽压：
- 7.26E-09mmHg at 25°C
- 存储条件/存储方法：
- 库房通风低温干燥
卡普托胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KQ8563000
- CHEMICAL NAME :
- Ethylamine,
2-((p-(butylthio)-alpha-phenylbenzyl)thio)-N,N-dimeth
yl-
- CAS REGISTRY NUMBER :
- 486-17-9
- BEILSTEIN REFERENCE NO. :
- 2625367
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H29-N-S2
- MOLECULAR WEIGHT :
- 359.63
- WISWESSER LINE NOTATION :
- 4SR DYR&S2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 17 mg/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3800 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 343 mg/kg
- TOXIC EFFECTS :
- Nutritional and Gross Metabolic - body temperature decrease
Behavioral - convulsions or effect on seizure threshold
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1630 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,154,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 116 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 108,201,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 136,440,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 72 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 12,448,1963
