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羟丁卡因 基本信息
- 中文名称：
- 羟丁卡因
- 中文别名：
- 羟丁卡因
- 英文名称：
- Benzoic acid,4-(butylamino)-2-hydroxy-, 2-(dimethylamino)ethyl ester
- 英文别名：
- 2-(dimethylamino)ethyl 4-(butylamino)-2-hydroxybenzoate;
Salicacaine;
Oxypentocain;
Salicain;
Idrossitetracaina [DCIT];
Oxitetracainum;
4-Butylamino-2-hydroxy-benzoesaeure-(2-dimethylamino-aethylester);
Salicaine (anesthetic);
Hydroxytetracain;
Hydroxamethocaine;
Rhenocain;
Hydroxytetracainum [INN-Latin];
4-butylamino-2-hydroxy-benzoic acid-(2-dimethylamino-ethyl ester);
Hydroxytetracaine
- CAS No.：
- 490-98-2
- 分 子 式：
-
C15H24N2O3
- 分 子 量：
- 280.36
- 精确分子量：
- 280.17900
- PSA：
- 61.80000
- InChI：
- The Key: DHCUQNSUUYMFGX-UHFFFAOYSA-N
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
- 分子结构式：
-
- SDS：
- 查看
羟丁卡因 物化性质
- 密度：
- 1.114g/cm3
- 沸点：
- 415.1ºC at 760mmHg
- 闪点：
- 204.9ºC
- 折射率：
- 1.557
- 蒸汽压：
- 1.76E-07mmHg at 25°C
羟丁卡因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VO1932000
- CHEMICAL NAME :
- Salicylic acid, p-(butylamino)-,
2-(dimethylamino)ethyl ester
- CAS REGISTRY NUMBER :
- 490-98-2
- BEILSTEIN REFERENCE NO. :
- 2125583
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C15-H24-N2-O3
- MOLECULAR WEIGHT :
- 280.41
- WISWESSER LINE NOTATION :
- 4MR DQ CVO2N1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 90 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intratracheal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 2,112,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 115 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- KLWOAZ Klinische Wochenscrift. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1922- Volume(issue)/page/year:
31,97,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 104,40,1952
